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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | 附睾炎:基于临床和基础研究的总结启示显示文摘急性附睾炎在泌尿外科门诊的病人中有共同的临床表现。大多数情况下,性传播疾病或者泌尿系的感染都会引起病原菌的感染,并通过泌尿生殖道逆行引发急性附睾炎。虽然保守治疗可能对大多数患者有效并能根除病原菌,但有研究表明这类患者中少精子症甚至无精子症患者升高至40%。为了探讨引起这种现象和随后对精子功能损伤的潜在原因,我们建立了附睾炎的动物模型。研究数据表明附睾管里聚集着异常表达的免疫细胞、免疫调节基因以及病原菌敏感分子。我们推测在附睾头部存在一个耐药微环境,而炎症反应常发生在附睾尾部。这与附睾在不需要降低自身抵抗上行感染能力的前提下,当精子从睾丸中射出后,保护其不受新产生的抗精子抗体损害的观点相一致。然而,严重的炎症反应,特别是在附睾尾部,也可能迁延引发附睾结构和功能的损害。通过对动物模型临床观察研究,我们更好地理解附睾的免疫微环境,附睾炎的易感因素以及合理的治疗,在此基础上减轻附睾炎对附睾的损害,降低这类人群不育的发生率。 | Vera Michel Adrian Pilatz Mark P Hedger Andreas Meinhardt | 2015 | Asian Journal of Andrology2015，17，5： | 16 |
| 3 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 4 | Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma显示文摘AIM:To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS:The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls.Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal,hepatic and splenic veins were examined.Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS:In the majority of patients,hepatomegaly was observed.Lesions were mostly hypoechoic and mixed,solitary or multiple.Some of the patients presented with dilated splenic veins and hepatofugal blood flow.A pulse wave was registered in the centre and at the margins of lymphoma.The average velocity of the pulse wave was higher at the margins (P>0.05).A continuous venous wave was found only at the margins of lymphoma.There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r=390,P<0.01).HPI was significantly lower in patients with lymphomas than in controls (P<0.05),pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION:Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity.Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. | Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 5 | Final safety results of BO17704(A-VAiL):a phase III randomized study of first-line bevacizumab(BV)and cisplatin/gemcitabine(CG)in patients(pts)with ad-vanced or recurrent nonsquamous non-small cell lung cancer(NSCLC)显示文摘 | Hirsh V Ramlau R von Pawel J Zatloukal P Vera G Leighl N Mezger J Archer V Reck M | 2009 | J Clin Oncol2009，，： | 1 |
| 6 | Generation of DNA profiles from fabrics without DNA extraction 显示文摘 | Adrian L Vera P Yuvaneswari C S | 2010 | Forensic Sci Int(Genetics)2010，4，： | 1 |
| 7 | Is C-realrive Protein an indegendent risk factor for essential hypertension显示文摘 | Bautista LE Loez jaramaillo P vera LM | 2005 | J Hypertens2005，19，5： | 1 |
| 8 | The neutrophil as a cellular source of cheraokines 显示文摘 | SCAPINI P LAPINET VERA J A GASPERINI S | 2000 | Immunological Reviews2000，177，： | 1 |
| 9 | Determination of nitrate and nitrite by high-performance liquid chromatography in human plasma 显示文摘 | VERA J ZOLTAN P STEFAN A | 2002 | Analytica Che-mica Acta2002，780，： | 1 |
| 10 | Is C-reactive protein an independent risk factor for essential hypertension显示文摘 | Bautista LE López-Jaramillo P Vera LM | 2001 | J Hypertens2001，19，5： | 1 |
| 11 | Is C-reative protein an independent risk factor for essential hypertension显示文摘 | BAUTISTA L E LOPEZ-JARAMILLO P VERA L M | 2001 | J Hypertens2001，19，5： | 1 |
| 12 | Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker显示文摘 | Ray P Rialon-Guevara KL Veras E | | 0，，05： | 1 |
| 13 | Comparing human pan- creatic cell secretomes by in vitro aptamer selection identifies cy clophilin B as a candidate pancreatic cancer biomarker显示文摘 | Ray P Rialon-Guevara KL Veras E | 2012 | J Clin In vest2012，122，5： | 1 |
| 14 | Determination of partition and diffusion coefficients of components of two rubber adhesives in different multilayer materials显示文摘 | Nerin C Gaspar J Vera P | 2013 | International Journal of Adhesion and Adhesives2013，40，： | 1 |
| 15 | Is C - reactive protein and independent risk factor for essential hypertension 显示文摘 | Bautista LE Lopes-Jaramillo P vera LM | 2001 | J Hypertens2001，19，5： | 1 |
| 16 | Is C-reactive protein an independent risk factor for essential hypertensipn显示文摘 | Bautista LE Lopez-J P Vera LM | 2001 | J Hypertens2001，19，11： | 1 |
| 17 | C - reactive protein is an independont risk factor for essential hypertension 显示文摘 | Bautista LE Lopez - Jaramillo P Vera LM | 2001 | Hypertens2001，19，5： | 1 |
| 18 | Determination of nitrate and nirie by high performance liquid chromatography in human plasma 显示文摘 | VERA J ZOLTAN P STEFAN A | 2002 | Analytica Chemiea Acta2002，78，6： | 1 |
| 19 | AC Imped- ance Monitoring of Pitting Corrosion of Stainless Steel Un- der a Wet Dry Cyclic Condition in Chloride Containing Environment 显示文摘 | VERA CRUZ R P NISHIKATA A TSURU T | 1996 | Corrosion Science1996，38，8： | 1 |
| 20 | Strategic leadership for ex- ploration and exploitation: The moderating role of environmental dy- namism 显示文摘 | JANSEN J J P VERA D CROSSAN M | 2009 | The Leadership Quarterly2009，20，1： | 1 |
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