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| 1 | The development and application of Laboratory Animal Science in China显示文摘The 14th Scientific Congress of the Chinese Association for Laboratory Animal Science was held on October 11‐12,2018 in Qingdao,China.During this congress,an international forum on the development of Laboratory Animal Sciences(LAS)worldwide was held in which participants learnt about the development of new LAS resources and technologies,as well as the progress of LAS in China.The main points that were discussed are as follows.After nearly a century of development,there are more than 200 species of experimental animals,and more than 20 000 inbred lines,outbred lines,genetic engineered animals,animal models of diseases,and other resources all over the world,which provide abundant experimental animal resources for scientific research.These resources are widely used in life science research. | Patri Vergara Grant Morahan | 2018 | Animal Models and Experimental Medicine2018，1，4： | 4 |
| 2 | 针灸疗法的证据:亟需在临床实践和卫生政策中得到充分利用显示文摘许能贵教授及其同事呼吁推动针灸确证证据的传播和加大对有潜力针灸疗法的研究投入。针灸作为起源于2000年前的中医疗法,目前在世界范围内得到了医生和患者的广泛应用1.传统中医理论将针灸的疗效归因于通过刺激经络(“气”流动的通道)上特定的身体区域(穴位)来调节身体,现代科学也为针灸的疗效提供了越来越多的生物学证据2。 | 陆丽明 张誉清 汤小荣 葛淑琦 文豪 曾婧纯 王莱 曾召 Gabriel Rada Camila Avila Camilo Vergara 汤煜媛 张培铭 陈柔皓 董昱 魏晓菁 骆文 王琳 Gordon Guyatt 唐纯志 许能贵 吴一凡 | 2022 | 英国医学杂志中文版2022，25，6： | 4 |
| 3 | Memory consolidation during sleep and adult hippocampal neurogenesis显示文摘In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review. | Iyo Koyanagi Katherine G.Akers Pablo Vergara Sakthivel Srinivasan Takeshi Sakurai Masanori Sakaguchi | 2019 | Neural Regeneration Research2019，14，1： | 4 |
| 4 | DNA methylation of embryogenic carrot cell cultures and its variations as caused by mutation, differentiation, hormones and hypomethylating drugs显示文摘 | F. LoSchiavo L. Pitto G. Giuliano G. Torti V. Nuti-Ronchi D. Marazziti R. Vergara S. Orselli M. Terzi | 1989 | Theoretical and Applied Genetics1989，，3： | 3 |
| 5 | Effect of n ? 3 HUFA level in broodstock diets on egg quality of gilthead sea bream ( Sparus aurata L.)显示文摘 | Hipólito Fernández-Palacios María Soledad Izquierdo Lidia Robaina Antonio Valencia María Salhi JoséM. Vergara | 1995 | Aquaculture1995，，3： | 2 |
| 6 | Permanent direct his bundle pacing does not induce ventricular dyssynchrony unlike conventional right ventricular apical pacing显示文摘 | Domenico Catanzariti Massimiliano Maines Claudio Cemin Gianpaolo Broso Tiziana Marotta Giuseppe Vergara | 2006 | Journal of Interventional Cardiac Electrophysiology2006，，2： | 2 |
| 7 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 8 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 9 | Morpho-an atomical Characteristics on Spikelet Filling of Different Tiller Orders in Rice 显示文摘 | KIM J D VERGARA B S | 1991 | Korean Journal of Crop Science1991，36，6： | 1 |
| 10 | Calciumactivated potassium channels 显示文摘 | Vergara C Latorre R Marrion N V | 1998 | Curr Opin Neurobiol1998，8，： | 1 |
| 11 | Studies on the biofiltration capacity of Gracilariopsis longissima : From microscale to macroscale显示文摘 | Hernandez I Perez-Pastor A Vergara J J | 2006 | Aquaculture2006，252，： | 1 |
| 12 | Heritahility esti- mates of larval and spat shell height in the Chilean blue mussel (Mytilus chilensis Hupe 1854) produced under controlled laborato ry conditions 显示文摘 | Toro J E Alcapan A C Vergara A M | 2004 | Aquae Res2004，35，： | 1 |
| 13 | Adsorption kinetics of cesium and oxygen on GaAs (100): A model for the activation layer of GaAs photocathodes显示文摘 | Vergara G Gomez L J Capmany J | 1992 | Surface Science1992，278，1： | 1 |
| 14 | Effect of Dif- ferent Gas Stunning Methods on Manchega Suckling Lamb Meat Packed under Different Modified Atmospheres 显示文摘 | BORNEZ R LINARES M B VERGARA H | 2010 | Meat Science2010，84，4： | 1 |
| 15 | Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat显示文摘 | Luis M. Moquillaza María-Angeles Aller Maria-Paz Nava Luis Santamaría Patri Vergara Jaime Arias | 2009 | Acta Histochemica2009，，4： | 1 |
| 16 | An outlook on ovarian cancer and borderline ovarian tumors:focus on genomic and proteomic findings显示文摘 | Tinelli A Vergara D Martignago R Leo G Pisanò M Malvasi A | | 0，，： | 1 |
| 17 | Stress and antibiotics alter luminal and wall‐adhered microbiota and enhance the local expression of visceral sensory‐related systems in mice显示文摘 | M. Aguilera P. Vergara V. Martínez | 2013 | Neurogastroenterol Motil2013，，8： | 1 |
| 18 | Calcium- activated potassium channels 显示文摘 | Vergara C Latorre R Marrion NV | 1998 | Curr Opin Neurobi- ol1998，8，3： | 1 |
| 19 | AC polarographic determination of cloxacillin 显示文摘 | Nunez - Vergara LJ Silva MM Squella LA | 1982 | J Assoc Off Anal Chem1982，65，： | 1 |
| 20 | Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis显示文摘 | Mercedes Vergara Xavier Calvet Marta Roqué | 2002 | European Journal of Gastroenterology & Hepatology2002，，： | 1 |
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