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		题名	作者	年代	出处	被引量
	1	Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients.	José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho	2006	World Journal of Gastroenterology2006，12，45：	3
	2	Epidemiological study on porcine circovirus identified in wild boar in Slovenia 显示文摘	VICENTE J SEGALES J HOFLE U	2004	Vet Rec2004，156，6：	1
	3	Pole-assignment problem for discrete- time linear periodic systems显示文摘	Vicente H Ana U	1987	Int J of Control1987，46，2：	1
	4	Influence of the enzyme derivative preparation and substrate structure on the enantiosetectivity of penicillin G acylase显示文摘	Silvia R Amaya S Vicente U	2002	Enzyme and Microbial Technology2002，31，：	1
	5	Pole-assignment problem for discrete-time linear periodic systems显示文摘	Vicente H Ana U	1987	Int J of Control1987，46，2：	1
	6	Lesions associated with Mycobacterium tuberculosis complex infection in the European wild boar显示文摘	Martin-Hernando M P Hofle U Vicente J	2007	Tuberculosis (Edinb)2007，87，4：	1
	7	Effects of dexmedetomide-fentanyl infusion on blood pressure and heart rate during cardiac surgery in children 显示文摘	KLAMT J G ANDRADE VICENTE W V GARCIA L U	2010	Anesthesiol Res Pract2010，19，8：	1
	8	Severe anaphylactic reaction after intracameral antibiotic administration during cataract surgery显示文摘	VILLADA J R VICENTE U JAVALOY J	2005	J Cataract Refract Surg2005，31，3：	1
	9	Epidemiological study on porcine circovirus type2(PCV-2)infection in the European wild boar(Sus scrofa)显示文摘	Vicente J Segalés J Hfle U	2004	Veterinary research2004，35，2：	1
	10	Epidemiological study on porcine eircovirus identified in wild boar in Slovenia显示文摘	VICENTE J SEGALES J HOFLE U	2004	Vet Rec2004，156，6：	1
	11	Neoadjuvant Therapy with Paclitaxel followed by 5- Fluorouracil, Epirubicin, and Cyclophosphamide Chemotherapyand Concurrent Trastuzumab in Human Epidermal Growth Factor Receptor 2-Positive Operable Breast Cancer: An Update of the Initial Randomized Study Population and Data of Additional Patients Treated with the Same Regimen 显示文摘	Aman U Buzdar Vicente Valero Nuhad K Ibrahim	2007	Clin Cancer Res2007，13，1：	1
	12	Laparoscopic adrenalectomy for large adrenal masses: a challenge or a routine? 显示文摘	MAESTRONE U VICENTE D DEL RIO P	2014	Minerva Chit2014，69，2：	1

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