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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 3 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 4 | Optimization of room-and-pillar dimensions using automated numerical models显示文摘This paper presents an optimization methodology for the geometric configuration of a room–and–pillar mining project,considering safety and operational restrictions while maximizing ore recovery.An underground manganese mine was chosen as a case study to investigate the capabilities of the presented methodology.A software package(OPTIMINE)was implemented to address the computational demand in an automated manner.Three–dimensional finite difference analyses were performed in FLAC3D and used as implicit functions to consider safety in terms of the factor of safety and room convergence.The obtained results showed that recovery could be increased from 44%to more than 80%in a safe manner. | Gian Franco Napa-García Tais Renata Camara Vidal Félix Navarro Torres | 2019 | International Journal of Mining Science and Technology2019，29，5： | 2 |
| 5 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | José Antonio Alburquerque Pablo Salazar Vidal Barrón José Torrent María del Carmen del Campillo Antonio Gallardo Rafael Villar | 2013 | Agronomy for Sustainable Development2013，，3： | 2 |
| 6 | ECG after near-drowning mimicking acute coronary syndrome with left main coronary artery involvement显示文摘We present the case of a 74-year-old man with diabetes and hypertension who had to be rescued owing to a near-drowning syndrome at sea.When he was rescued,he complained of dyspnea and chest pain.An electrocardiogram(ECG)suggested acute coronary syndrome(ACS)affecting the left main coronary artery.Therefore,he was referred to our hospital for urgent coronary angiography. | Alfredo Vidal García Javier Lacunza Ruiz José María Lpez Ayala Mariano Valdés | 2013 | World Journal of Emergency Medicine2013，4，1： | 2 |
| 7 | Determination of multiclass pesticides in food commodities by pressurized liquid extraction using GC-MS/MS and LC-MS/MS 显示文摘 | Frenich A G Salvador I M Vidal J L M Lopez T L | 2005 | Analytical and Bioanalytical Chemistry2005，33，78： | 1 |
| 8 | K nearest neighbours with mutual information for simultaneous classification and missing data imputation显示文摘 | Garcia-Laencina P J Saneho-Gomez J-L Figueiras Vidal A R | 2009 | Neurocomputing2009，72，79： | 1 |
| 9 | Synthesis of utility systems by simulated显示文摘 | Maia L O A Vidal L A Qassim R Y | 1995 | Comp & Chem Eng1995，19，： | 1 |
| 10 | Quantitative age-related changes in dorsal lateral geniculate nucleus rdlay neurons of the rat显示文摘 | VIDAL L RUIZ C VILLENA A | 2004 | Neuroscience esearch2004，48，： | 1 |
| 11 | Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in se- verely obese subjects 显示文摘 | Vidal J Ibarzabal A Romero F | 2008 | Obes Surg2008，18，9： | 1 |
| 12 | 5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome-a systematic review and meta-analysis 显示文摘 | Gurion R Vidal L Gafter-Gvili A | 2010 | Haematotogica2010，95，2： | 1 |
| 13 | Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry显示文摘 | VIDAL J L M FRENICH A G AGUILERA-LUIZ M M | 2010 | Analytical and Bioanalytical Chemistry2010，397，7： | 1 |
| 14 | Efficacy and safety of aminoglycoside monotherapy: systematic review and meta- analysis of randomized controlled trial显示文摘 | Vidal L Gafter- Gvili A Borok S | 2007 | J Antimicrob Chcmother2007，60，2： | 1 |
| 15 | Licofelone,a balanced inhibitor of cyclooxygenase and 5-lipoxygenase,reduces inflammation in a rabbit model of atherosclerosis显示文摘 | Gómez-Hernández A Sánchez-Galán E | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 16 | Linear transceiver design in nonregenerative relays with channel state information显示文摘 | Medina O M Vidal J Agustin A | 2007 | IEEE Trans on Signal Processing2007，55，6： | 1 |
| 17 | The ERBB4/HER4 intracellular domain 41CD is a BH3-only protein promot- ing apoptosis of breast cancer cells 显示文摘 | Naresh A Long W Vidal GA | 2006 | Cancer Res2006，66，12： | 1 |
| 18 | Prolonged cardioprotective effect of pyridostigmine encapsulated in liposomes 显示文摘 | VIDAL A T GUIMARAES H N De PAULA D C | 2010 | Life Sci2010，86，12： | 1 |
| 19 | Cell-cycle inhibitors:three families united bya common cause显示文摘 | Vidal A Koff A | 2000 | Gene2000，247，12： | 1 |
| 20 | Synthesis of utility systems with variable demands using simulated annealing显示文摘 | Maia L O A Vidal L A Qassim R Y | 1997 | Comp & Chem Eng1997，21，： | 1 |
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