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| 1 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 2 | 针灸和药物针灸治疗肥胖的疗效回顾显示文摘Objective:The purpose of this study is to review the impact on the usage of traditional Chinese medicine in the treatment of obesity,specifically the usage of acupuncture and phytoacupuncture.Methods:PubMed and Google Scholar databases were searched to identify randomized controlled trials,which the methodology focused on the use of acupuncture and phytoacupuncture for the treatment of obesity from the beginning of these databases to February 2018,supplementing with literature retrospective and manual searches.Results:A total of 8 trials including 566 participants met the selected criteria.In the alterations of the body mass index and waist circumference,acupuncture and phytoacupuncture seems to have a positive effect as opposed to the subjects who received superficial acupuncture or none.However,there were other parameters that showed promising results such as improvements in the levels of(1)serum total cholesterol,low-density lipoprotein and serum fasting triglyceride,(2)serum insulin and leptin,plasma ghrelin and cholecystokinin and(3)serum pro-oxidant antioxidant balance,as well as improvements in(4)skin fat thickness in the upper limbs,trunk and abdomen,(5)abdominal fat and deep subcutaneous fat tissue.The main acupoints employed in the selected studies are found along several meridians such as the stomach,spleen and conception vessel,and the plants used had the main objective of accelerating the metabolism,reducing appetite and resolving the unbalances in the genesis of obesity.Conclusion:It is suggested that acupuncture and phytoacupuncture can be useful tools for weight loss.When combined with a life-style change,they can contribute to achieve better results than just a lifestyle change by itself.Nevertheless,the need for further studies to clarify mechanisms of action and adequacy of protocols in order to obtain more homogeneous results is also present. | Rosa Vilares Santos Jorge Magalhaes Rodrigues Maria Irene Jesus | 2020 | World Journal of Acupuncture-Moxibustion2020，30，3： | 5 |
| 3 | Microstructure and properties of laser direct deposited CuNi17Al3Fe1.5Cr alloy显示文摘Thin walls of a copper-base alloy with the nominal composition CuNi17Al3Fe1.5Cr were successfully prepared by laser direct deposition additive manufacturing. The microstructure, as revealed by optical and scanning electron microscopy, indicated that the deposited material was fully dense and with a dendritic microstructure. The dendrites are parallel to the build-up direction, which is also the heat con-duction direction during deposition. X-ray diffraction analysis results show that the deposited material is composed of a single phase and a copper-based solid solution. Some precipitate particles of metal silicides were observed in the interdendritic region by scanning electron mi-croscopy. The ultimate tensile strength along the laser scanning direction reaches 735 MPa. The hardness is about Hv0.1 300. | Yong-zhong Zhang Can Huang Rui Vilar | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，3： | 4 |
| 4 | TA15钛合金表面激光熔化沉积Ti-Cr二元合金涂层显示文摘通过激光熔化沉积不同比例Ti与Cr的混合粉末,在TA15钛合金表面制备出Ti-Cr二元合金涂层,分析了涂层的组织、相组成、硬度及界面结合情况。结果表明,Ti与Cr在激光熔池中实现了原位合金化,沉积层内部组织致密,与基体冶金结合;随着Cr含量的增加,沉积涂层中析出TiCr2相,硬度增加;涂层在300℃下具有良好的组织及性能稳定性,经550℃保温2 h退火处理后,涂层中亚稳β-Ti发生不完全共析转变,涂层硬度增加;涂层具有良好的强韧性配合,与钛合金基体适配度高,可用于钛合金表面耐磨及抗擦伤涂层的制备。 | 张永忠 黄灿 MEACOCK Chris VILAR Rui | 2010 | 金属热处理2010，35，1： | 3 |
| 5 | Thermal stability and oxidation resistance of laser clad TiVCrAlSi high entropy alloy coatings on Ti–6Al–4V alloy显示文摘 | Can Huang Yongzhong Zhang Jianyun Shen Rui Vilar | 2011 | Surface & Coatings Technology2011，，6： | 2 |
| 6 | SCIENCE OF WINNING SOCCER:EMERGENT PATTERN-FORMING DYNAMICS IN ASSOCIATION FOOTBALL显示文摘Quantitative analysis is increasingly being used in team sports to better understand performance in these stylized,delineated,complex social systems.Here,the authors provide a first step toward understanding the pattern-forming dynamics that emerge from collective offensive and defensive behavior in team sports.The authors propose a novel method of analysis that captures how teams occupy sub-areas of the field as the ball changes location.The authors use this method to analyze a game of association football(soccer) based upon a hypothesis that local player numerical dominance is key to defensive stability and offensive opportunity.The authors find that the teams consistently allocated more players than their opponents in sub-areas of play closer to their own goal.This is consistent with a predominantly defensive strategy intended to prevent yielding even a single goal.The authors also find differences between the two teams' strategies:while both adopted the same distribution of defensive,midfield,and attacking players(a 4:3:3 system of play),one team was significantly more effective in maintaining both defensive and offensive numerical dominance for defensive stability and offensive opportunity.That team indeed won the match with an advantage of one goal(2 to 1) but the analysis shows the advantage in play was more pervasive than the single goal victory would indicate.The proposed focus on the local dynamics of team collective behavior is distinct from the traditional focus on individual player capability.It supports a broader view in which specific player abilities contribute within the context of the dynamics of multiplayer team coordination and coaching strategy.By applying this complex system analysis to association football,the authors can understand how players' and teams' strategies result in successful and unsuccessful relationships between teammates and opponents in the area of play. | VILAR Luís ARAUJO Duarte DAVIDS Keith BAR-YAM Yaneer | 2013 | Journal of Systems Science & Complexity2013，26，1： | 2 |
| 7 | Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C显示文摘AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis C.METHODS:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 wk.The primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well tolerated.CONCLUSION:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C. | Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 8 | Wideband Statistics of Signal Levels and Doppler Spread on an Over-the-sea Transhorizon Link显示文摘 | NDZI D AUSTIN J VILAR E | 1997 | IEE Seminar Digests1997，，： | 1 |
| 9 | The fold of α-synuclein fibrils显示文摘 | Vilar M Chou HT Lührs T | 2008 | Proc Natl Acad Sci USA2008，105，25： | 1 |
| 10 | Formaldehyde biodegradation in the presence of methanol under denitrifying conditions显示文摘 | EIROA M VILAR A KENNES C | 2006 | Chemical Technology and Biotechnology2006，81，3： | 1 |
| 11 | Electrodeposition of black chromium spectral- ly selective coatings from a Cr(III) - ionic liquid solution显示文摘 | Sonia Eugenio Carmen Mireya Rangel Rui Vilar Ana Maria Botelho do Rego | 2011 | Thin Solid Films2011，519，2： | 1 |
| 12 | Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors显示文摘 | Vilar E Salazar R Perez-Garcia J | 2007 | Endocr Relat Cancer2007，14，2： | 1 |
| 13 | Erythropoietin protects the in vitro blood brain barrier against VEGF-induced permeability显示文摘 | Martínez-Estrada O M Rodríguez-Millán E González-De Vicente E Reina M Vilaró S Fabre M | 2003 | Eur J Neurosci2003，18，： | 1 |
| 14 | Epithelial-mesenehymal transition in proliferative vitreoretinopathy: intermediate filament protein expression in retinal pigment epithelial cells显示文摘 | Casaroli R Pagan R Vilaró S | 1999 | Invest Ophthalmol Vis Sci1999，40，： | 1 |
| 15 | Propagation of flicker in electric power networks due to wind energy conversions systems显示文摘 | Carolina Vilar Moreno Hortensia Amaris Duarte Julio Vsaola Garcia | 2002 | IEEE Transactions on energy conversion2002，17，2： | 1 |
| 16 | Structure of NiCrAlY coatings deposited on single-crystal alloy turbine blade material by laser cladding 显示文摘 | VILAR R SANTOS E C FERREIRA P N FRANCO N DA SILVA | 2009 | Acta Materialia2009，57，18： | 1 |
| 17 | Clinical trial:a nutritional supplement Viusid,in combination with diet and exercise,in patients with nonalcoholic fatty liver disease显示文摘 | Vilar gomez E Rodriguez de miranda A Gra oramas B | | 0，，10： | 1 |
| 18 | An adaptive-network-based fuzzy inference system for classification of welding defects 显示文摘 | ZAPATA J VILAR R RUIZ R | 2010 | NDT & E International2010，43，3： | 1 |
| 19 | Dry Sliding Wear Behavior of Laser Clad TiVCrAlSi High Entropy Alloy Coatings on Ti-6Al-4V Substrate显示文摘 | HUANG C ZHANG Y Z VILAR R | | 0，，： | 1 |
| 20 | On the influence of retained austenite in the abrasive wear bchavlour of a laser surface melted tool steel 显示文摘 | Colaco R Vilar R | 2005 | Wear2005，258，14： | 1 |
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