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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Test and prediction of chloride diffusion in recycled aggregate concrete显示文摘Recycled aggregate concrete(RAC) specimens with different recycled coarse aggregate replacement ratios by mass(R) are fully immersed in a 10% chloride solution for 235 days. Both free chloride concentration(Cf) and total chloride concentration(Ct) are then measured employing a rapid chloride test(RCT) system. The Fick's second diffusion law is verified by the test data and used to predict chloride concentration distribution at different immersion periods. Additionally, pore structures of the new and old mortar in RAC are tested by mercury intrusion porosimetry(MIP). It is found that binding chloride concentration(Cb) linearly increases with Cf. In natural aggregate concrete(NAC), Cf is obviously smaller than that in the RAC in the same testing environment and this is different from the test results of Ct and Cb. Furthermore, the effects of R on the chloride concentration of RAC become severe for specimens subjected to long immersion periods, which can be explained in terms of the pore structures of the new mortar and old adhesive mortar in RAC. | XIAO Jian Zhuang YING Jing Wei TAM Vivian W.Y GILBERT Ian R | 2014 | Science China(Technological Sciences)2014，57，12： | 5 |
| 3 | Treatability studies of naphthalene in soil,water and air with persulfate activated by iron(Ⅱ)显示文摘Chemical oxidation was applied to an artificially contaminated soil with naphthalene(NAP).Evaluation of NAP distribution and mass reduction in soil,water and air phases was carried out through mass balance.Evaluation of NAP distribution and mass reduction in soil,water and air phases was carried out through mass balance.The importance of the air phase analysis was emphasized by demonstrating how NAP behaves in a sealed system over a 4 hr reaction period.Design of Experiments method was applied to the following variables:sodium persulfate concentration[SP],ferrous sulfate concentration[FeS04],and pH.The system operated with a prefixed solid to liquid ratio of 1:2.The following conditions resulted in optimum NAP removal[SP]=18.37 g/L,[FeSO4]=4.25 g/L and pH=3.00.At the end of the 4 hr reaction,62%of NAP was degraded.In the soil phase,the chemical oxidation reduced the NAP concentration thus achieving levels which comply with Brazilian and USA environmental legislations.Besides the NAP partitioning view,the monitoring of each phase allowed the variabilities assessment over the process,refining the knowledge of mass reduction.Based on NAP distribution in the system,this study demonstrates the importance of evaluating the presence of semi-volatile and volatile organic compounds in the air phase during remediation,so that there is greater control of the system as to the distribution and presence of the contaminant in the environment.The results highlight the importance of treating the contaminant in all its phases at the contaminated site. | Gabriela P.Mendes Vivian M.A.Magalhaes Lélia C·R·Soares Rayanne M.Aranha Claudio A.O.Nascimento Marilda M.G.R.Vianna Osvaldo Chiavone-Filho | 2020 | Journal of Environmental Sciences2020，32，4： | 4 |
| 4 | Sexually dimorphic expression of multiple doublesex -related genes in the embryonic mouse gonad显示文摘 | Shinseog Kim Jae R Kettlewell Robert C Anderson Vivian J Bardwell David Zarkower | 2002 | Gene Expression Patterns2002，，1： | 2 |
| 5 | Journal of Solid State Electrochemistry显示文摘 | Silva Claudineia R Conceio Cleone D Bonifcio Viviane G Orlando Fatibello Filho Teixeira Marcos F S | 2009 | 13:6652009，13，： | 1 |
| 6 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 7 | Teixeira determination of the chemical oxygen demand (COD) using a copper electrode:a clean alternative method显示文摘 | Silva C R Conceicao C D C Viviane G | 2005 | Solid state electrochem2005，，10： | 1 |
| 8 | Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack显示文摘 | Martin D V Vivian R V O Remco M P V P etal | 2005 | Molecular Plant-Microbe Interactions2005，18，： | 1 |
| 9 | TLRs 2 and 4 are not involved in hypersusceptibility to acute pseudomonas aeruginosa lung infections显示文摘 | Reuben R Viviane B Michel H | 2005 | Immunol2005，175，： | 1 |
| 10 | Optimal dose of Gd-DTPA in dynamic MR studies 显示文摘 | Henry R Vivian S | 2001 | Magnetic Resoneance in Medicine2001，46，： | 1 |
| 11 | Electrophoretic study in two sympatric and syntopic species of the genus Procalus Clark, 1865 (Coleoptera Chrysomelidae) 显示文摘 | Cortes X J Viviane R Ricardo G | 1993 | Revista Chilena de Entomologia1993，20，： | 1 |
| 12 | Growth Restriction,Leptin,and the Programming of Adult Behavior in Mice显示文摘 | Lauritz R M Vivian Z Alise M | 2014 | Behav Brain Res2014，，275： | 1 |
| 13 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 14 | Meta-Analysis of the Efficacy of Hormone Replacement Therapy in Treating and Preventing Osteoporosis in Postmenopausal Women显示文摘 | George W Peter T Beverley S Gordon G Joan P Nicole Z Vivian R David H Diane O Ann C | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 15 | Comparison of Methods to Estimate the Time-to-Failure Distribution in Degradation Tests 显示文摘 | Viviane R B Enrico A C | 2004 | Quality and Reliability engineering International2004，20，4： | 1 |
| 16 | The impact of friendship on synchronous collaborative retrieval tasks in the primary school显示文摘 | Dinet J Vivian R | 2011 | British Journal of Educational Technology2011，，10： | 1 |
| 17 | Mechanisms of tryptophan fluorescence shifts in proteins显示文摘 | Vivian J T Callis P R | 2001 | Biophys2001，80，5： | 1 |
| 18 | Mechanisms of tryptophan fluorescence shifts in proteins显示文摘 | Vivian J T Callis P R | | Biophys J0，80，5： | 1 |
| 19 | The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma显示文摘 | OOI S M VIVIAN J B COHEN R J | 2009 | Int Urol Nephrol2009，41，3： | 1 |
| 20 | Effect of differentcooking methods on the oxidation,proximate and fatty acid composi-tion of silver catfish fillets显示文摘 | JUCIELI W VIVIAN C B CRISTIANE P R | 2008 | Food Chemistry2008，106，1： | 1 |
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