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| 1 | Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis显示文摘我们在一张多样的临床的人口评估了同样需要的 tadalafil 的功效和安全(与改变耐心的人口分布,疾病严厉,和 comorbid 医药条件) 有可勃起的机能障碍(编辑) 的亚洲人。五双窗帘的综合分析,控制安慰剂的试用(N = 1 046 ) 被执行。病人们随机被分配收到 10 mg tadalafil (N = 185 ) , 20 mg tadalafil (N = 510 ) ,或安慰剂(N = 351 ) 。功效评价包括了可勃起的功能(IIEF ) 的国际索引,性相遇侧面(9 月) 日记和全球评价问题(GAQ ) 。收到 10 mg 或 20 mg tadalafil 从 baseline-to-end 看了重要改进的病人指在在分析的所有临床的亚人口的可勃起的功能(IIEF-EF ) 领域 20 的国际索引的可勃起的功能领域上,与收到安慰剂的病人相比(P < 0.001 ) 。给吝啬的成功看的 10-mg 和 20-mg tadalafil 组为性交尝试64.1%和70.5%评价( SEP3 ,成功的性交)分别地,在安慰剂与33.4%相比组织( P < 0.001 ),并且分别地,在结束的85.5%和85.4%报导改进勃起削尖 GAQ 对43.5%在安慰剂组织( P < 0.001 )。Tadalafil 很好越过学习的所有组被容忍。头疼和背疼痛是最经常报导的不利事件。总的来说, tadalafil 越过有编辑的亚洲男人的一个多样的临床的系列有效、很好容忍。 | Ying-Lu Guo Vijay P Viswanathan Han-Sun Chiang Hyung Ki Choi Andrew Wai Chun Yip Wei Shen Vladimir Kopernicky | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 2 | Dissociation behavior of “dry water” C_3H_8 hydrate below ice point:Effect of phase state of unreacted residual water on a mechanism of gas hydrates dissociation显示文摘The results on a dissociation behavior of propane hydrates prepared from 'dry water' and contained unreacted residual water in the form of ice inclusions or supercooled liquid water(water solution of gas) were presented for temperatures below 273 K.The temperature ramping or pressure release method was used for the dissociation of propane hydrate samples.It was found that the mechanism of gas hydrate dissociation at temperatures below 273 K depended on the phase state of unreacted water in the hydrate sample.Gas hydrates dissociated into ice and gas if the ice inclusions were in the hydrate sample.The samples of propane hydrates with inclusions of unreacted supercooled water only(without ice inclusions) dissociated into supercooled water and gas below the pressure of the supercooled water-hydrate-gas metastable equilibrium. | Andrey O Drachuk Vladimir P Melnikov Nadezhda S Molokitina Anatoliy N Nesterov Lev S Podenko Aleksey M Reshetnikov Andrey Yu Manakov | 2015 | Journal of Energy Chemistry2015，24，3： | 2 |
| 3 | Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial显示文摘 | Thomas E Hutson Vladimir Lesovoy Salman Al-Shukri Viktor P Stus Oleg N Lipatov Angel H Bair Brad Rosbrook Connie Chen Sinil Kim Nicholas J Vogelzang | 2013 | Lancet Oncology2013，，13： | 2 |
| 4 | Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma显示文摘AIM:To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS:The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls.Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal,hepatic and splenic veins were examined.Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS:In the majority of patients,hepatomegaly was observed.Lesions were mostly hypoechoic and mixed,solitary or multiple.Some of the patients presented with dilated splenic veins and hepatofugal blood flow.A pulse wave was registered in the centre and at the margins of lymphoma.The average velocity of the pulse wave was higher at the margins (P>0.05).A continuous venous wave was found only at the margins of lymphoma.There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r=390,P<0.01).HPI was significantly lower in patients with lymphomas than in controls (P<0.05),pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION:Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity.Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. | Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 5 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 6 | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment:critical assessment and systematization显示文摘In this review,we tried to systematize all the evidence(from PubMed[MEDLINE],Scopus,Cochrane Library,EBSCO,Embase,and Google Scholar)from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment.Regarding the outcomes of varicocele repair,we considered semen improvement and pregnancy and analyzed them separately.Based on the 2011 Oxford CEBM Levels of Evidence,we assigned a score to each trial that studied the role of the predictor.We systematized the studied predictors based on the total points,which were,in turn,calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant,into three levels of significance:predictors of high,moderate,and low clinical significance.Preoperative total motile sperm count(TMSC)coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy.In addition,for semen improvement alone,scrotal Doppler ultrasound(DUS)parameters,sperm DNA fragmentation index(DFI),and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy. | Azizbek B Shomarufov Vladimir A Bozhedomov Nikolay I Sorokin Igor P Matyukhov Abdukodir A Fozilov Shukhrat A Abbosov Armais A Kamalov | 2023 | Asian Journal of Andrology2023，25，1： | 2 |
| 7 | Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening显示文摘Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed. | Ekaterina I Galanzha Valery V Tuchin Vladimir P Zharov | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 8 | Study of multiwalled graphite nanotubes and filaments formation from carbonized products of polyvinyl alcohol via catalytic graphitization at 600 ~800 ℃ in nitrogen atmosphere显示文摘 | KRIVORUCHKO Oleg P MAKSIMOVA Nadezhda I ZAIKOVSKII Vladimir I | 2000 | Carbon2000，38，7： | 1 |
| 9 | Fiber sensor for simultaneous mesurement of voltage and temperature显示文摘 | Valery N Filippov Andrey N Starodumov Vladimir P Minkovich | 2000 | IEEE Photonics Technology Letters2000，12，11： | 1 |
| 10 | Detailed aH and 13C NMR structural assignment of three biologically active lignan lactones 显示文摘 | Vladimir C G H Rosangela da S Susimaire P | 2006 | Spectroehim Aeta PartA2006，63，： | 1 |
| 11 | Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells显示文摘 | KAREL D IGOR P VLADIMIR K | 2006 | Bioorg Med Chem2006，14，3： | 1 |
| 12 | Syntheses of 19- haptens of epipregnan- olone and pregnanolone显示文摘 | IVAN C VLADIMIR P MARTIN H | 2006 | Steroids2006，71，： | 1 |
| 13 | Recent advances with liposomes as pharmaceutical carriers显示文摘 | Vladimir P | 2005 | Nat Rev Drug Discov2005，4，2： | 1 |
| 14 | Fracture detection in a carbonate reservoir using a variety of seismic methods显示文摘 | Maria A P Vladimir G Reinaldo J M | 1999 | Geophysics1999，64，4： | 1 |
| 15 | Anodic oxidation of ethanol on inorganic membrane-based electrodes 显示文摘 | Liao Shi-jun Vladimir L Leslic P | 2004 | Applied Catasis A2004，258，： | 1 |
| 16 | Fragmental approach in QSPR显示文摘 | NIKOLAI S Z VLADIMIR A P | 2002 | J Chem Inf Comput Sci2002，42，： | 1 |
| 17 | Photoacoustic flow cytom- etry显示文摘 | Ekaterina I G Vladimir P Z | 2012 | Methods2012，57，3： | 1 |
| 18 | Dynam- ics of steam accumulation 显示文摘 | VLADIMIR D S BLAZENKA M SANJA P | 2012 | Applied Thermal Engi- neering2012，37，： | 1 |
| 19 | Lipopilic tartaric acid esters as enantioselective ionophores显示文摘 | Vladimir P Mice K Martin E | 1989 | Angew Chem Int Ed1989，28，： | 1 |
| 20 | Immunogenicity of the histidineto-tyrosine staphylococcal enterotoxin B mutant protein in C3H/HeJ mice显示文摘 | VLADIMIR S DMITRIY P | 2004 | Toxicon2004，434，43： | 1 |
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