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| 1 | Serum zonulin levels in patients with liver cirrhosis:Prognostic implications显示文摘BACKGROUND Increased gut permeability and bacterial translocation play an important role in liver cirrhosis.Zonulin is a recently recognized protein involved in the disintegration of the intestinal barrier.AIM To investigate possible differences in serum zonulin levels among patients with different cirrhosis stages and their potential prognostic implications.METHODS Consecutive cirrhotic patients who attended our liver clinic were included in the study.Serum zonulin levels,clinical,radiological and biochemical data were collected at baseline.Patients who accepted participation in a regular surveillance program were followed-up for at least 12 mo.RESULTS We enrolled 116 cirrhotics[mean Child-Turcotte-Pugh(CTP)score:6.2±1.6;model for end-stage liver disease score:11±3.9].The causes of cirrhosis were viral hepatitis(39%),alcohol(30%),non-alcoholic fatty liver disease(17%),and other(14%).At baseline,53% had decompensated cirrhosis,48% had ascites,and 32% had history of hepatic encephalopathy.Mean zonulin levels were significantly higher in patients with CTP-B class than CTP-A class(4.2±2.4 ng/dL vs 3.5±0.9 ng/dL,P=0.038),with than without ascites(P=0.006),and with than without history of encephalopathy(P=0.011).Baseline serum zonulin levels were independently associated with the probability of decompensation at 1 year(P=0.039),with an area under the receiving operating characteristic of 0.723 for predicting hepatic decompensation.Higher CTP score(P=0.021)and portal vein diameter(P=0.022)were independent predictors of mortality.CONCLUSION Serum zonulin levels are higher in patients with more advanced chronic liver disease and have significant prognostic value in identifying patients who will develop decompensation. | Theodoros A Voulgaris Dimitrios Karagiannakis E Hadziyannis Spilios Manolakopoulos Georgios P Karamanolis George Papatheodoridis John Vlachogiannakos | 2021 | World Journal of Hepatology2021，13，10： | 2 |
| 2 | Epithelial–mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic显示文摘 | Angeliki Voulgari Alexander Pintzas | 2009 | BBA - Reviews on Cancer2009，，2： | 2 |
| 3 | Construction and initial characterization of Escherichia coli strains with few or no intact chro- mosomal rRNA operons 显示文摘 | Asai T Condon C Voulgaris J | 1999 | Journal of Bacteriology1999，181，： | 1 |
| 4 | Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with infliximab显示文摘 | Argyropoulou MI Glatzouni A Voulgari PV | 2005 | Joint Bone Spine2005，72，6： | 1 |
| 5 | Management of ear- ly-stage cervical carcinoma by modified (Type II ) radical hys- terectomy显示文摘 | Michalas S Rodolakis A Voulgaris Z | 2002 | Gynecol Oncol2002，85，： | 1 |
| 6 | Incidence and prevalence of rheumatoid arthritis,based on the 1987 American College of Rheumatology criteria:asystematic review显示文摘 | Alamanos Y Voulgari P Drosos A | 2006 | Semin Arthritis Rheum2006，36，3： | 1 |
| 7 | Sustained clinical response and high infliximab survival in psoriatic arthritis patients:a 3-year long-term study显示文摘 | Voulgari PV Venetsanopoulou AI Exarchou SA | | 0，，05： | 1 |
| 8 | Diffusion tensor and dynamic susceptibility contrast MRI in glioblastoma显示文摘 | Anastasia K. Zikou George A. Alexiou Paraskevi Kosta Ann Goussia Loukas Astrakas Periklis Tsekeris Spyridon Voulgaris Vasiliki Malamou-Mitsi Athanasios P. Kyritsis Maria I. Argyropoulou | 2011 | Clinical Neurology and Neurosurgery2011，，6： | 1 |
| 9 | Management of early stage cervical carcinoma by modified Type of radical hys terectomy显示文摘 | Michalas S Rosolakis A Voulgaris Z | 2002 | Gynecol Oncol2002，85，3： | 1 |
| 10 | Development of a microcontroller based, pbotovoltaic maximum power point tracking control system 显示文摘 | KOUTROULIS E KALAITZAKIS K VOULGARIS N C | 2001 | IEEE Transaction on Power Electronics2001，16，1： | 1 |
| 11 | Cancer and pregnancy:a comprehensive review显示文摘 | Voulgaris E Pentheroudakis G Pavlidis N | 2011 | Surg Oncol2011，20，： | 1 |
| 12 | Increased weight people with metabolic syndrome compared with metabolically healthy obese individuals显示文摘 | Voulgari C Tentolouris N heart failure risk in normal Dilaveris P | 2011 | J Am Coll Cardiol2011，58，13： | 1 |
| 13 | miRNAs andrelated polymarphisms in rheumatoid arthritis susceptibility 显示文摘 | Chatzikyriakidou A Voulgari PV Georgiou I | 2012 | Autoimmun Rev2012，11，9： | 1 |
| 14 | Evaluation of the acoustic Doppler velo- cimeter (ADV) for turbulence measurements显示文摘 | Voulgaris G Trowbridge J H | 1998 | Journal of Atmos- pheric and Oceanic Technology1998，15，1： | 1 |
| 15 | On the variation of small -signal alphas of a P - N - P - N device with current显示文摘 | E S Yang N C Voulgaris | 1967 | Solid - State Electronics1967，10，： | 1 |
| 16 | Diabetic cardiomy opathy : from the pathophysiology of the cardiac myocytes to cur- rent diagnosis and management strategies 显示文摘 | Voulgari C Papadogiannis D Tentolouris N | 2010 | Vasc Health Risk Manag2010，6，： | 1 |
| 17 | Developmentof a microcontroller-based, photovoltaic maximum power point tracking control system显示文摘 | Koutroulis E Kalaitzakis K Voulgaris N C | 2001 | IEEE Transactions on Power Electronics2001，16，1： | 1 |
| 18 | Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers, and strategies to overcome drug re- sistance in the clinic 显示文摘 | Voulgari A Pintzas A | 2009 | Biochim Biophys Acta2009，1796，2： | 1 |
| 19 | Risk factors and out- comes associated with acquisition of colistin resistant KPC produ- cing Klehsiella pneumoniae: A matched case control study显示文摘 | Zarkotou O Pournaras S Voulgari E | 2010 | J Clin Microbiol2010，48，6： | 1 |
| 20 | Sediment resuspension,flocculation,and settling in a macrotidal estuary显示文摘 | Wang Y Voulgaris G Li Y | 2013 | Journal of Geophysical Research2013，118，： | 1 |
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