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| 1 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 2 | The effect of breed and intrauterine crow-ding on fetal erythropoiesis on day35of gestation in swine显示文摘 | VALLET J L KLEMCKE H G CHRISTENSON R K | 2003 | J Anim Sci2003，81，9： | 1 |
| 3 | Histopathologie efficacy of ribavirin monotherapy in kidney allograft recipients with chronic hepatitis C 显示文摘 | FONTINE H VALLET A SELVES J | 2004 | Transplantation2004，78，6： | 1 |
| 4 | Personalized information retrieval based on context and ontological knowledge 显示文摘 | Mylonas P H Vallet D Castell P | 2008 | The Knowledge Engineering Review2008，23，1： | 1 |
| 5 | The effect of breed and intrauterine crowding on fetal erythropoiesis on day 35 of gestation in swine 显示文摘 | Vallet J L Klemcke H G Christenson R K | 2003 | J Anita Sei2003，81，： | 1 |
| 6 | Hepatitis C and human immune deficiency coinfection at the era of highly active antiretroviral therapy显示文摘 | Pol S Vallet Pichard A Fontaine H | 2002 | J Viral Hepat2002，9，1： | 1 |
| 7 | How to titrate vasopressors against fluid loading in septic shock显示文摘 | Vallet B Tytgat H Lebuffe G | 2007 | Advances in Sepsis2007，6，： | 1 |
| 8 | Personalized information retrieval based on context and ontological knowledge 显示文摘 | Mylonas P H Vallet D | 2008 | The Knowledge Engineering Review2008，23，1： | 1 |
| 9 | The effect of breed and intrauterine crowding on fetal erythropoiesis on day 35 of gestation in swine 显示文摘 | Vallet J L Klemcke H G Christenson R K | 2003 | J AnimSci2003，81，： | 1 |
| 10 | Fraction spaced multi-carrier modulation显示文摘 | Vallet R Taieb K H | 1995 | Wireless Personal Commun1995，2，： | 1 |
| 11 | A radioimmunoassay for porcine intrauterine folate binding protein 显示文摘 | Vallet J L Christenson R K Klemcke H G | 1999 | Journal of Animal Science1999，77，： | 1 |
| 12 | Fraction spaced multi-carrier modulation 显示文摘 | Vallet R Taieb K H | 1995 | Wirwlwess Personal Communications1995，，2： | 1 |
| 13 | Purification and characterization of intrauterine folate-binding proteins from swine显示文摘 | Vallet J L Christenson R K Klemcke H G | 1998 | Biol Reprod1998，59，： | 1 |
| 14 | Efficacy and safety of anti TNFot in non - infectious uveitis: a multi - center retrospective study显示文摘 | GARNIER M B VALLET H SEVE P | 2014 | Acta ophthalmologica2014，92，： | 1 |
| 15 | The effect of breed and intrauterine crowding on fetal erythropoiesis on day 35 of gestation in swine 显示文摘 | VALLET J L KLEMCKE H G CHRISTENSON R K | 2003 | J Anim Sci2003，81，9： | 1 |
| 16 | Tocilizumab in severe and refractory non-infectious uveitis显示文摘 | Papo M Bielefeld P Vallet H | 2014 | Clin Exp Rheumatol2014，32，484： | 1 |
| 17 | The endothelium in intensive care显示文摘 | Wiel E Vallet B ten Cate H | 2005 | Crit Care Clin2005，21，3： | 1 |
| 18 | The effect of breed and intrauterine crow- ding on fetal erythropoiesis on day 35 of gestation in swine 显示文摘 | VALLET J L KLEMCKE H G CHRISTENSON R K | | J Anita Sci 200a 81(9)0，，： | 1 |
| 19 | Purification and characterization of intrauterine folate-binding proteins from swine显示文摘 | Vallet J L Christenson R K Klemcke H G | 1998 | Biol Reprod1998，59，： | 1 |
| 20 | Interrelationships among conceptus size,uterine protein secretion,fetal erythropoiesis,and uterine capacity显示文摘 | VALLET J L KLEMCKE H G CHRISTENSON R K | 2002 | J Anim Sci2002，80，3： | 1 |
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