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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Reevaluation of formulas for predicting creatinine clearance in adults and children,using compensated creatinine methods显示文摘 | Wuyts B Bernard D Van den Noortgate N | 2003 | Clin Chem2003，49，61： | 1 |
| 5 | Claiming more: The increased voluminosity of patent applications and its determinants 显示文摘 | Van Zeebroeck N van Pottelsberghe de la Potterie B Guellec D | 2009 | Research Policy2009，38，6： | 1 |
| 6 | Seismic tomography with P and S data reveals lateral variations in the rigidity of deep slabs显示文摘 | Widiyantoro S Kennett B L N van der Hilst R D | 1999 | Earth and Planetary Science Letters1999，173，： | 1 |
| 7 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts 显示文摘 | Van Rens B T de Groot P N Van Der L T | 2002 | Theriogenology2002，57，6： | 1 |
| 8 | Various behavioral signs of estrus and their relationship with time of ovulation in dairy cattle显示文摘 | Roelofs J B van Eerdenburg F J C M Soede N M | 2005 | Theriogenology2005，63，5： | 1 |
| 9 | Ultralow-k dielectrics made by supercritical foaming of thin polymer films显示文摘 | Krause B Koops G H van der Vegt N F A | 2002 | Advanced Materials2002，14，15： | 1 |
| 10 | By any means necessary: Theeffects ofregula- tory focus and moral conviction on hostile and benevolent forms of collectiveaction 显示文摘 | ZAAL M P VAN LAAR C STHAL T ELLEMERS N DERKS B | 2011 | British Journal of Social Psychology2011，50，： | 1 |
| 11 | A 3-center comparison of l-year mortality outcomes between transcatheter aortic valve implantation and surgical aortic valve replacement on the basis of propensity score matching among inter- mediate-risk surgical patients 显示文摘 | Piazza N Kalesan B van Mieghem N | 2013 | JACC Cardiovasc Interv2013，6，5： | 1 |
| 12 | Lactate fuels the human brain during exercise显示文摘 | Quistoff B Secher N H Van Lieshout J J | 2008 | FASEB J2008，22，10： | 1 |
| 13 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells 显示文摘 | van Baren N Bonnet MC Dreno B | 2005 | J Clin Oncol2005，23，35： | 1 |
| 14 | The role of the inflamma- some in cellular responses to toxins and bacterial effectors 显示文摘 | Freche B Reig N van der Goot FG | 2007 | Semin lmmunopathol2007，29，3： | 1 |
| 15 | High-pressure methane and carbon dioxide adsorption on dry and moisture-equilibrated Pennsylvanian coals显示文摘 | Krooss B M van Bergen F Gensterblum Y Siemons N Pagnier H J M David P | 2002 | Int J Coal Geol2002，51，2： | 1 |
| 16 | Aluminum chemistry in a forested Spodosol显示文摘 | Driscoll C T Van B N Mulder J | 1985 | Soil Sci Soc Am J1985，49，： | 1 |
| 17 | Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfm in the CAM model 显示文摘 | I)ebefve E Pegaz B van den Bergh H Wagnieres G Lange N Ballini JP | 2008 | Angiogenesis2008，11，3： | 1 |
| 18 | Joint life-cy- cle dynamies of new and remanufactured products 显示文摘 | Debo L G Toktay L B Van Wassenhove L N | 2006 | Pro- duction and Operations Management2006，15，4： | 1 |
| 19 | Influence of algae species and cultivation conditions on algal removal in direct filtration显示文摘 | Petrusevski B Vlaski A Van Breeman A N | 1993 | War Sci Tech1993，27，11： | 1 |
| 20 | Interven-tions for ingrowing toenails显示文摘 | Eekhof J A Van Wijk B Knuistingh N A | 2012 | Cochrane Database Syst Rev2012，21，4： | 1 |
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