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| 1 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Usefulness of multislice computed tomography for detecting obstructive coronary artery clisease显示文摘 | Rensing BJ Van Geuns RM | 2002 | Am J Cardiol2002，89，： | 1 |
| 4 | Donor-specific T-cell reactivity identifies kindey transplant patients in whom immunosuppressive therapy can be safely reduced 显示文摘 | van Besouw NM van der Mast BJ de Kuiper P | 2000 | Transplantation2000，70，1： | 1 |
| 5 | Mildly, oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio 显示文摘 | Navab M Hama-Levy S Van Lenten BJ | 1997 | J Clin Invest1997，99，8： | 1 |
| 6 | Radiographically occult lung cancer treated with fiberoptic bronchoscopic eletrocautery:a pilot study of a simple and inexpensive technique显示文摘 | Van Boxem TJ Venmans BJ Schramel FM | 2005 | Eur Respir J2005，11，： | 1 |
| 7 | Effect of light therapy on biopterin, neopterin and tryptophan in pa'- tients with seasonal affective disorder显示文摘 | Hoekstra R Fekkes D van de Wetering BJ | 2003 | Psychiatr Res2003，120，1： | 1 |
| 8 | D-4F,an apoA-I mimetic peptide inhibits the inflammatory response induced by influenza A infection of human type Ⅱ pneumocytes显示文摘 | Van Lenten BJ Wagner AC Navab M | | 0，，20： | 1 |
| 9 | Medication adherence in patients with rheumatoid arthritis:a critical ap- praisal of the existing literature显示文摘 | van den Bemt BJ Zwikker HE van den Ende CH | 2012 | Expet Rev Clin Immunol2012，8，4： | 1 |
| 10 | Optimizing the technique of embryotransfer显示文摘 | Mains L Van Voorhis BJ | 2010 | Fertii Steril2010，94，3： | 1 |
| 11 | Severe adverse reactions after the use of sulphur hexafluoride (SonoVue) as an ultrasonographic contrast agent 显示文摘 | de Groot MC van Zwieten-Boot BJ van Grootheest AC | 2004 | Ned Tijdschr Geneeskd2004，148，38： | 1 |
| 12 | Toll-like receptor triggering in cord blood mesenchymal stem cells显示文摘 | Van den Berk LC Jansen BJ Siebers-Vermeulen KG | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 13 | Transpedicular wedge resection osteotomy for the treatment of a kyphotic Andersson lesion complicating ankylosing spondylitis 显示文摘 | Van Royen BJ Kastelijns RC Noske DP etal | 2006 | Eur Spine J2006，15，2： | 1 |
| 14 | Outcome of bronchial carcinoma in situ显示文摘 | Venmans BJ van Boxem TJ Smit EF | 2000 | Chest2000，117，6： | 1 |
| 15 | Usefulness of multislice computed tomography for detecting obstructive coronary artery disease显示文摘 | Nieman K Rensing BJ van Geuns RJ | 2002 | Am J Cardiol2002，89，： | 1 |
| 16 | High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection 显示文摘 | Van Lenten BJ Wagner AC Nayak DP | 2001 | Circulation2001，103，18： | 1 |
| 17 | Endometrial polyps in reproductive-age fertile and infertile women显示文摘 | Silberstein T Saphier O Van Voorhis BJ | 2006 | Isr Med Assoc2006，8，3： | 1 |
| 18 | Biomechanical analysis of posture in patients with spinal kyphosis due to ankylosing spondylitis: a pilot study显示文摘 | Bot SD Caspers M Van Royen BJ eta| | 1999 | Rheumatology(Oxford)1999，38，5： | 1 |
| 19 | Evidence for a selective migration of fetus-specific CD4 + CD25 bright regulatory T cells from the peripheral blood to the decidua in human pregnancy显示文摘 | Tilburgs T Roelen DL van der Mast BJ | | 0，，08： | 1 |
| 20 | As kyphoplan:a program for deformity planning in ankylosing spondylitis显示文摘 | Van Royen BJ Scheerder FJ Jansen E | | 0，，： | 1 |
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