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| 1 | 血管紧张素Ⅱ诱导的高血压所引起的T淋巴细胞活化与血管炎症的中枢和外周机制显示文摘研究者先前就发现,T淋巴细胞对血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)诱导的高血压的发生发展是必需的,但是,高血压发生过程中的T细胞活化机制尚不明确。该文研究者探讨了中枢神经系统和血压升高在AngⅡ导致的T细胞活化与血管炎症中的作用。 | 张玲玉 叶鹏 Marvar PJ Thabet SR Guzik TJ Lob HE McCann LA Weyand C Gordon FJ Harrison DG | 2010 | 中华高血压杂志2010，18，12： | 15 |
| 2 | 三维超声心动图测定正常人及二尖瓣病变伴或不伴房颤患者左心耳容量及其收缩功能显示文摘目的 :探讨三维超声心动图评价左心耳功能的价值。方法 :采用三维超声心动图对 5 2例正常人及二尖瓣病变伴或不伴心房纤颤患者测定左心耳容量及其收缩功能 ,并与二维超声心动图和多普勒超声心动图比较。结果 :根据左心耳容量测定计算出的左心耳射血分数 (EFv)与左心耳峰值血流排空速度 (Pev)相关良好 (r=0 .818,P<0 .0 1) .根据左心耳面积测定计算出的左心耳射血分数 (EFa)与 Pev的相关性低于前者 (r=0 .744 4,P<0 .0 1)。将所有患者的 EFv与 EFa进行比较 ,虽然两者间未见明显差异 (P>0 .0 5 ) ,但在重复性检验中 EFa的范围和两测量数值之差的均数加减标准差都大于 EFv的相应数值 ,左心耳容量在正常人明显小于有二尖瓣病变的患者 ,而收缩功能则前者明显高于后者 (P值均 <0 .0 1) .在相同二尖瓣病变患者之间进行比较 ,合并房颤者左心耳容量大于窦性心率者 ,而左心耳收缩功能则前者低于后者 (P值均 <0 .0 5 )。另外 ,二尖瓣病变合并房颤者的左心耳自发性“超声造影”发生率高于窦性心率者。结论 :用三维超声心动图测量左心耳容量和评价其收缩功能是可行的 ,评价左心耳功能时较二维超声心动图更准确 ,二尖瓣病变患者的左心耳容量增加 ,收缩功能减低 ,常伴左心耳自发性“超声造影”,上述改变在合并房颤者更? | 李越 Herman FJ Mannaerts OttoKamp Gabriel Valocik CeesA Visser | 2000 | 中国超声医学杂志2000，16，4： | 12 |
| 3 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 4 | Current and future therapies for inherited cholestatic liver diseases显示文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases. | Wendy L van der Woerd Roderick HJ Houwen Stan FJ van de Graaf | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 5 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 6 | 三维超声心动图测定左心耳容量及其收缩功能的初步研究显示文摘目的 观察三维超声心动图测定左心耳容量的可行性。方法 对 10名患者行多平面经食管超声心动图 (TEE)检查。应用三维超声心动图采取圆盘总和方法 (disksummation)测定左心耳舒张末期容量 (EDV)和左心耳收缩末期容量 (ESV)。用二维超声心动图测定左心耳舒张末期面积 (EDA)和左心耳收缩末期面积(ESA)。上述左心耳容量和面积的测定均在二个独立的观察者之间以及同一观察者两次观察间重复进行。由三维超声心动图容量测定结果计算出左心耳的射血分数 (EFv) ,由二维超声心动图的面积测定结果计算出左心耳射血分数 (EFa)。结果 三维超声心动图测定左心耳EDV为 ( 19.5± 10 .9)ml,ESV为 ( 13 .5± 9.5 )ml ,EFv为0 .3 5± 0 .14。二维超声心动图测定左心耳EDA为 ( 8.7± 2 .2 )cm2 ,ESV为 ( 5 .9± 3 .5 )cm2 ,EFa为 0 .3 5± 0 .2 2。以上测量内容在观察者之间及观察者内的重复性检验中均未见显著性差异 ,EFv与EFa之间亦无显著性差异。但无论在观察者间或观察者内的重复性检验中EFa的范围和两测量数值之差均大于EFv的相应值。结论 三维超声心动图测量左心耳容量和评价其收缩功能是可行的 ,这种测定方法可能有助于改善二维超声心动图评价左心耳功能的准确性。 | 李越 Otto Kamp Herman FJ Mannaerts Gabriel Valocik Cees A Visser | 2000 | 中华超声影像学杂志2000，9，5： | 6 |
| 7 | The magnetic response of graphene split-ring metamaterials显示文摘Graphene has emerged as a promising platform for THz plasmonics,allowing high confinement,long lifetimes and fast electrical tunability.Here,we predict a strong magnetic dipole response by graphene split nanorings at THz frequencies,allowing the attainment of metamaterials with a high degree of field confinement(approximately one hundredth of the excitation wavelength)that is not reachable with conventional noble metals.The magnetic response of highly doped graphene split-rings in the far-infrared is much stronger than that displayed by gold structures of similar thicknesses.We further explored stacked graphene layers as a practical way of producing high-frequency magnetism in thin,electrically tunable metamaterials.Our results support the great potential of using graphene to achieve electrically tunable magnetic metamaterials. | Nikitas Papasimakis Sukosin Thongrattanasiri Nikolay I Zheludev FJ Garcıa de Abajo | 2013 | Light(Science & Applications)2013，2，1： | 5 |
| 8 | 种植密度对向日葵杂交种子物质分配及生产力的影响显示文摘 | Vill.,FJ 魏守恩 | 1994 | 国外农学(油料作物)1994，，4： | 5 |
| 9 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 10 | 从价值分析到价值管理——一种概念阐述的尝试显示文摘自从近50年前L.D.Miles首次将价值分析技术付诸应用以来,该项技术已经在世界范围内得到了普及,并且它已从一种符合技术经济要求的面向产品、过程与服务的优化方法,发展成为一种用于在没有规范算法或只有部分规范的算法系统中,寻求问题解决的有效方法体系。如此看来,有必要以展望其在欧洲未来发展的观点,对价值管理体系及德国工程师协会系统发展与规划设计分会(VDIGSP)所参与的合作,作一个中期评价。 | Gier.,FJ 刘耀乙 | 1999 | 工程设计学报1999，6，2： | 3 |
| 11 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 3 |
| 12 | Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats显示文摘Manual acupuncture(MA)has presented analgesic activity against neuropathic painin patients and ani mal models,yet a series of questions remain:Is MAeffectiveness dependent of acupoint selection or combination? Is it equally efficient when treat ment starts on the initial(acute)or sub-chronic phase of spinal nerveligation(SNL)-induced neuropathy?Is MAeffect related to | Cidral-Filho FJ | 2011 | 针刺研究2011，36，5： | 3 |
| 13 | Proliferating cell nuclear antigen(PCNA):a new marker to study human colonic cell proliferation显示文摘 | Kubben FJ Peeters H Aesevoets A | 1994 | Gut1994，35，4： | 2 |
| 14 | 清洁度对航空轴承可达寿命的影响显示文摘 | Eber.,FJ 张文军 | 1996 | 国外轴承技术1996，，2： | 2 |
| 15 | Transcatheter arterial embolization--major complications and prevention显示文摘 | Miller FJ Jr Mineau DE | 1983 | Cardiovasc Intervent Radiol1983，6，3： | 2 |
| 16 | Endothelial cell chimerism after renal transplantation and vascular rejection.显示文摘 | Lagaaij EL Cramer-Knijnenburg GF van Kemenade FJ | | 0，，： | 2 |
| 17 | Preliminary studies on the ionic pulse of snowmelt runoff in the Urumqi River, Xinjiang, Northwest China显示文摘IONIC pulse of snowmelt and its runoff in seasonally snow-covered alpine catchments was de-fined by Johannessen et al. When a snowpack begins melting, the first meltwater drainingthrough the pack carries a large fraction of the soluble ions with it, an ionic pulse. 10% of thefirst meltwater may drain 80% of the soluble contents out of the snowpack within severalhours or days. In other words, an ionic pulse designates a peak in ionic concentration duringthe initial melting process of a snowpack. The peak has been proved by a plot test 10 times | Liu, FJ Williams, M Cheng, GD Yang, DQ | 1997 | Chinese Science Bulletin1997，42，19： | 2 |
| 18 | Health Professional Guide to Rehabilitation of the Patient with Osteoporosis显示文摘 | Francis J Bonner FJ Jr Mehrshed S | 2003 | Osteoporos Int2003，14，2： | 2 |
| 19 | Thermal Properties of PHB/PEG Blends显示文摘Thermal properties of PHB and PHB/PEG blends were investigated by differential scanning calorimetry (DSC) and melt index (Ml) test. DSC thermograms indicate that two components of blend are miscible. From the DSC thermogram, we can also conclude that the melting point of PHB descends with the increased content of PEG, this can improve PHB processing properties.From Ml data, we may draw the same conclusion. | Zhang, QQ Zhang, Y Wang, FJ Liu, LR Wang, C | 1998 | Journal of Materials Science & Technology1998，14，1： | 2 |
| 20 | Synergistic effect of IL-1,IFN-γ,and TNF-α on RANTES production by human renal tubular epithelial cells in vitro显示文摘 | Deckers JG Van Der Woude FJ Ven Der Kooij SW | 1998 | J Am Soc Nephrol1998，9，2： | 2 |
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