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| 1 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 2 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 3 | Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer显示文摘 | Van Cutsem E Kōhne C Hitre E | | New England Journal of Medicine0，，： | 3 |
| 4 | Quantitative assessment of resource-use efficient cropping systems: a case study for Ansai in the Loess Plateau of China显示文摘 | Lu C H van htersum M K Rabbinge R | 2003 | European Journal of Agronomy2003，19，2： | 1 |
| 5 | The coexistence of geopolymeric gel and calcium silicate hydrate at the early stage of alkaline activation显示文摘 | Yip C K Lukey G C van Deventer J S J | 2005 | Cem Concr Res2005，35，9： | 1 |
| 6 | Significant changes in the bacterioplankton community structure of a maritime Antarctic fieshwater lake following nutrient enrichment显示文摘 | PEARCE D A van der GAST C J WOODWARD K | 2005 | Microbiology2005，151，10： | 1 |
| 7 | Dendritic Cells as a tool to induce transplantation tolerance:Obstacles and Opportunities显示文摘 | Van Kooten C Lombardi G Geldennan K A | 2010 | Transplantation2010，，： | 1 |
| 8 | Treatment re- suits of sinonasal inverted papilloma: an 18-year study 显示文摘 | Sham C L Woo J K van Hasselt C A | 2009 | Am J Rhinol Allergy2009，23，2： | 1 |
| 9 | Synthetic modal interferometric laser imaging显示文摘 | Van Voorthies K L Aleksoff C C | 1977 | App Opt1977，16，9： | 1 |
| 10 | Multiple Rh messenger RNA isoforms are produced by alternative splicing显示文摘 | LE VAN K C CHERIF-ZAHAR B RAYNAL V | 1992 | Blood1992，80，： | 1 |
| 11 | Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit 显示文摘 | Van Den Akker F Feil I K Roach C | 1997 | Protein Science1997，6，： | 1 |
| 12 | Personality in teams: Its relations to social cohesion, task cohesion, and team performance 显示文摘 | Van Vianen A E M De Dreu C K W | 2001 | European Journal of Work and Organizational Psychology2001，，10： | 1 |
| 13 | Comparative study on the in vitro/in vivo estrogenic potencies of 17显示文摘 | VAN DEN BELT K BERCKMANS P VANGENECHTEN C | 2004 | Aquatic Toxicology2004，66，2： | 1 |
| 14 | Direct VUV photolysis of chlorinated methanes and their mixtures in a nitrogen stream 显示文摘 | Alapi T Van K C Van H L | 2007 | Chemosphere2007，66，1： | 1 |
| 15 | An iterated dynasearch algorithm for the single-machine total weighted tardiness scheduling problem显示文摘 | Congram R K Potts C N van de Velde S | 2002 | Informs Journal on Computing2002，14，： | 1 |
| 16 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 17 | The occurrence of polyeylie sesqui-, tri-, and oligoterpe- noids derived from a resinous polymeric eadinene in crude oils from southeast Asia 显示文摘 | Van Aarssen B G K Hessels J K C Abbink O A De Leeuw J W | 1992 | Geoehim Cosmoehim Aeta1992，56，3： | 1 |
| 18 | Anaerobic ammonia oxidation in the presence of nitrogen oxides (NOx) by two different lithotrophs 显示文摘 | Schmidt I Hermelink C Van de Pas- Schoonen K | 2002 | Applied and Environmental Microbiology2002，68，11： | 1 |
| 19 | Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing human four-repeat tau protein 显示文摘 | Van den Haute C Van Dorpe J | 1999 | Am J Pathol1999，155，6： | 1 |
| 20 | Comparative study on the in vitro/in vivo estrogenic potencies of 17β-estradiol,estrone,17α-ethynylestradiol and nonylphenol显示文摘 | VAN DEN BELT K BERCHMANS P VANGENECHTEN C | 2004 | Aquatic Toxicology2004，66，2： | 1 |
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