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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Increases in cerebral interstitial fluid adenosine concentration during hypoxia,local potassium infusion, and ischemia 显示文摘 | Park TS Rubio R | 1986 | J Cereb Blood Flow Metab1986，6，： | 1 |
| 3 | Repair of large midline incisional hernias with polypropyl-ene mesh:comparison of three operative techniques 显示文摘 | de Vries Reilingh Ts van Geldere D Langenhorst B | 2004 | Hernia2004，8，1： | 1 |
| 4 | Pulmonary aspergilllosis显示文摘 | Tomee JF van der Werf TS | | 0，，： | 1 |
| 5 | Pulmonary aspergillosis显示文摘 | Tomee JF van der Werf TS | | 0，，： | 1 |
| 6 | Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain显示文摘 | Van Err MN Easterday WR Simonson TS | 2007 | J Clin Microbiol2007，45，1： | 1 |
| 7 | Temporal changes in mouse aortic wall gene expression during the develop- ment of elastase- induced abdominal aortic aneurysms 显示文摘 | Van Vickle-Chavez S J Tung WS Absi TS | 2006 | J Vasc Surg2006，43，5： | 1 |
| 8 | Bronchoscopic diagnosis of pulmonary infiltrates in granulocytopenic patients with hematologic malignancies:BAL versus PSB and PBAL显示文摘 | Boersma WG Erjavec Z van der Werf TS | 2007 | Respir Med2007，101，2： | 1 |
| 9 | Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study显示文摘 | Lapperre TS Sont JK van Schadewijk A | 2007 | Respiratory research2007，8，： | 1 |
| 10 | Pulmonary aspergillosis显示文摘 | Tomee JF van der Werf TS | 2001 | Neth J Med2001，59，5： | 1 |
| 11 | Functional characterization of the bladder cancer marker, BLCA-4显示文摘 | Van Le TS Myers J Konety BR | 2004 | CIin Cancer Res2004，10，4： | 1 |
| 12 | Diagnostic performance of stress myocardial perfusion imaging for coronary artery disease: a systematic review and meta-analysis显示文摘 | de Jong MC Genders TS van Geuns RJ | 2012 | Eur Radiol2012，22，9： | 1 |
| 13 | A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma显示文摘 | Gujral TS van Veelen W Richardson DS | 2008 | Cancer Res2008，68，5： | 1 |
| 14 | Fatal haemorrhage from Dieulafoy's disease of the bronchus显示文摘 | van der Werf TS Timmer A Zijlstra JG | 1999 | Thorax1999，54，2： | 1 |
| 15 | The value of clinical judgment in the diagnosis of nosocomial pneumonia显示文摘 | Hlelling TS Van Way C Krantz S | 1996 | Am J Surg1996，171，6： | 1 |
| 16 | Increases in cerebral interstitial fluid adenosine concentration during hypoxia,local potassium infusion ,and ischemia显示文摘 | Van Wylen DG Park TS Rubio R | 1986 | J Cereb Blood Flow Metab1986，6，： | 1 |
| 17 | Autologous tissue repair of large abdominal wall defects 显示文摘 | de Vries Reilingh TS Bodegom ME van Goor H | 2007 | BrJ Surg2007，94，： | 1 |
| 18 | Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis 显示文摘 | Spee B Arends B Van TS | 2007 | Comp Hepatol2007，31，6： | 1 |
| 19 | Bronchoscopic diagnosis of pulmonary infiltrtes in granulocytopenic patients with hematologic malignancies:BAL versus PSB and PBAL显示文摘 | Boersma WG Erjavec Z van der Werf TS | 2007 | Rospir Med2007，101，2： | 1 |
| 20 | Repair of large midline incisional hernias with polypropylene mesh:Comparison of three operative techniques显示文摘 | De Vries Reilingh TS Van Geldere D Langenhorst B | 2004 | Hernia2004，8，1： | 1 |
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