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| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology显示文摘 | J. Arends G. Bodoky F. Bozzetti K. Fearon M. Muscaritoli G. Selga M.A.E. van Bokhorst-de van der Schueren M. von Meyenfeldt G. Zürcher R. Fietkau E. Aulbert B. Frick M. Holm M. Kneba H.J. Mestrom A. Zander | 2006 | Clinical Nutrition2006，，2： | 6 |
| 3 | Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | van der Veer E Nong Z O′Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 4 | Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins显示文摘 | van der Velden J Papp Z Zaremba R | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 5 | Appe-tite regulation genes are associated with body mass index in blackSouth African adolescents:A genetic association study显示文摘 | LOMBARD Z CROWTHER NJ VAN DER MERWE L | 2012 | BMJOpen2012，2，00： | 1 |
| 6 | Managing Conflicting Public Values:Governing with Integrity and Effectiveness显示文摘 | DE GRAAF G VAN DER WAL Z | 2010 | The American Review of Public Administration2010，40，6： | 1 |
| 7 | Pre-B-cell colony-enhancing factor regulates NAD +-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation 显示文摘 | van der Veer E Nong Z O'Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 8 | Pre-B-cell colonyenhancing factor regulates NAD +-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | van der Veer E Nong Z O' Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 9 | Plaque instability frequently occurs days or weeks before occlusive coronary thrombosis:a pathological thrombectomy study in primary percut-aneous coronary intervention 显示文摘 | Rittersma S Z Van der Wal A C Koch K T | 2005 | Circulation2005，111，9： | 1 |
| 10 | Activated carbon as an electron acceptor and redox mediator during the anaerobic biotransformation of azo dyes显示文摘 | VAN der Z F P BISSCHOPS I A E LETTINGA G | 2003 | Environ Sci Technol2003，37，： | 1 |
| 11 | Three- year outcome of sirolimus-eluting versus bare-metal stents for the treatment of ST-segment elevation myocardial infarction from the MISSION Intervention Study) 显示文摘 | ATARY J Z van der HOEVEN B L LIEM S S | 2010 | Am J Cardiol2010，106，1： | 1 |
| 12 | Modeling sorting dynamics of cohesive and non-cohesive sediments on intertidal flats under the effect of tides and wind waves显示文摘 | ZHOU Z COCO G van der WEGEN M | 2015 | Continental Shelf Research2015，104，： | 1 |
| 13 | lYre-B-cell colony-enhan- cing factor regulates NAD + -dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | Van der Veer E Nong Z O'Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 14 | Role of quinones in the biodegradation of priority pollutants, A review 显示文摘 | FISLD J A CERVANTES F J VAN der Z F P | 2000 | Water Sci Technol2000，42，： | 1 |
| 15 | Vascular endothelial growth factor/vascular permeability factor augments nitric oxide recease from quiescent rabbit and human vascular endothelium显示文摘 | Van der Zee R Murohara T Luo Z | 1997 | Girculation1997，95，4： | 1 |
| 16 | Cardiomyocyte stiffness in diastolic heart failure显示文摘 | BORBELY A VAN DER VELDEN J PAPP Z | 2005 | Circulation2005，111，： | 1 |
| 17 | Novel in situ forming degradable dextran hydrogels by Michael addition chemistry: Synthesis, rheology and degradation显示文摘 | Hiemstra C Van der Aa L J Zhong Z | 2007 | Macromolecules2007，40，： | 1 |
| 18 | Factors affecting irrig- ant extrusion during root canal irrigation : a systematic review 显示文摘 | Boutsioukis C Psimma Z van der Sluis LW | 2013 | Int Endod J2013，46，7： | 1 |
| 19 | Bronchoscopic diagnosis of pulmonary infiltrates in granulocytopenic patients with hematologic malignancies:BAL versus PSB and PBAL显示文摘 | Boersma WG Erjavec Z van der Werf TS | 2007 | Respir Med2007，101，2： | 1 |
| 20 | Calpain-I induced alterations in the cytoskeletal structure and impaired me- chanical properties of single myocytes of rat heart 显示文摘 | Papp Z van der Velden J Stienen GJ | 2000 | Cardiovasc Res2000，45，4： | 1 |
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