|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver-specific gene expression in mesenchymal stem cells is induced by liver cells显示文摘AIM: The origin of putative liver cells from distinct bone marrow stem cells, e.g. hematopoietic stem cells or multipotent adult progenitor cells was found in recent in vitro studies. Cell culture experiments revealed a key role of growth factors for the induction of liver-specific genes in stem cell cultures. We investigated the potential of rat mesenchymal stem cells (MSC) from bone marrow to differentiate into hepatocytic cells in vitro. Furthermore,we assessed the influence of cocultured liver cells on induction of liver-specific gene expression.METHODS: Mesenchymal stem cells were marked with green fluorescent protein (GFP) by retroviral gene transduction. Clonal marked MSC were either cultured under liver stimulating conditions using fibronectin-coated culture dishes and medium supplemented with SCF, HGF,EGF, and FGF-4 alone, or in presence of freshly isolated rat liver cells. Cells in cocultures were harvested and GFP+ or GFP- cells were separated using fluorescence activated cell sorting. RT-PCR analysis for the stem cell marker Thy1 and the hepatocytic markers CK-18, albumin, CK-19,and AFP was performed in the different cell populations.RESULTS: Under the specified culture conditions, rat MSC cocultured with liver cells expressed albumin-, CK-18,CK-19, and AFP-RNA over 3 weeks, whereas MSC cultured alone did not show liver specific gene expression.CONCLUSION: The results indicate that (1) rat MSC from bone marrow can differentiate towards hepatocytic lineage in vitro, and (2) that the microenvironment plays a decisive role for the induction of hepatic differentiation of rMSC. | Claudia Lange Philipp Bassler Michael V. Lioznov Helge Bruns Dietrich Kluth Axel R. Zander Henning C. Fiegel | 2005 | World Journal of Gastroenterology2005，11，29： | 31 |
| 2 | Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells显示文摘瞄准:为了与胎儿的肝细胞(FLC ) 和可能性在合作文化调查间充质的干细胞(MSC ) 的 hepatocytic 区别膨胀,区分了 hepatocytic 房间。方法:MSC 被制动火箭与绿荧光灯的蛋白质(GFP ) 标记病毒的基因转导变异。同种细胞的显著 MSC 在用与干细胞补充的fibronectin涂的培养皿和媒介刺激条件的肝下面是也有教养的因素( SCF ), hepatocyte 生长因素( HGF ),表皮的生长因素( EGF ),和成纤维细胞生长因素 4 ( FGF-4 )独自一个,或在刚孤立的 FLC 的存在。在合作文化的房间被收获,并且 GFP+ 或 GFP- 房间用荧光被分开激活的房间排序。为肝 specific 标记 cytokeratin-18 (CK-18 ) 的反向的抄写聚合酶链反应(RT-PCR )( 法新社) ,白朊,和 alpha-fetoprotein 在不同房间人口被执行。结果:在指定文化条件下面,与 FLC co 有教养的老鼠 MSC 超过二个星期表示了白朊, CK-18,和 AFP-RNA。在 wk 3, MSC 失去了 hepatocytic 基因表示,可能由于 cocultured FLC 的增生。FLC 也在合作文化和一个很高的生长潜力显示出稳定的肝 specific 基因表情。结论:从骨髓的老鼠 MSC 能面对 FLC 在试管内区分 hepatocytic 房间,在合作文化的 MSC 的存在也为 FLC 的扩大和区别提供有益的环境。 | Claudia Lange Helge Bruns Dietrich Kluth Axel R Zander Henning C Fiegel | 2006 | World Journal of Gastroenterology2006，12，15： | 23 |
| 3 | Repression of the Arabidopsis thaliana Jasmonic Acid/Ethylene-Induced Defense Pathway by TGA-Interacting Glutaredoxins Depends on Their C-Terminal ALWL Motif显示文摘Glutaredoxins 是小热马厩 oxidoreductases 从谷胱甘肽(GSH ) 的转移电子到氧化半胱氨酸残余,从而贡献蛋白质正直和规定。在 Arabidopsis thaliana,花的 glutaredoxins ROXY1 和 ROXY2 和导致病原体的 ROXY19/GRX480 与 TGACG (TGA ) 主题绑定家庭的 bZIP 抄写因素交往。ROXY1, ROXY2,和 TGA 因素 PERIANTHIA, TGA9,和 TGA10 在花的开发起必要作用。相反,宫外地否定地表示了 ROXY19/GRX480 调整 /ethylene (et ) 导致了的 jasmonic 酸(JA ) 的表示通过要求 clade II 抄写因素 TGA2, TGA5,或 TGA6 的未知机制的防卫基因。这里,我们报导 21 中的至少 17 个打编码为 Arabidopsis 染色体的植物特定的 glutaredoxins 在一个 yeast-two-hybrid 系统与 TGA2 交往。调查他们的能力防碍 JA/ET-induced 基因的表示,我们开发了一个短暂表示系统。ORA59 (OCTADECANOID 应答的 ARABIDOPSIS AP2/ERF-domain 蛋白质 59 ) 的激活由抄写因素 EIN3 (乙烯 INSENSITVE 3 ) 的倡导者被共同表示的 ROXY19/GRX480 镇压。抑制在 ROXY19/GRX480 的 C 终点取决于 L **LL 主题。这个通常认为的蛋白质相互作用领域最近被描述为为 TGA/ROXY 相互作用是必要的。17 测试 ROXY 蛋白质中的十个压制了 ORA59 倡导者活动,它与 C 终端 ALWL 主题的存在相关,它为在花开发的 ROXY1 功能是必要的。ROXY19/GRX480-mediated 压抑取决于 GSH 有约束力的地点,建议 TGA 因素或迄今为止未知的目标蛋白质的那氧化还原作用修正为 ORA59 的抑制是重要的倡导者活动。 | Mark Zander Shuxia Chen Julia Imkampe Corinna Thurow Christiane Gatz | 2012 | Molecular Plant2012，5，4： | 11 |
| 4 | ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology显示文摘 | J. Arends G. Bodoky F. Bozzetti K. Fearon M. Muscaritoli G. Selga M.A.E. van Bokhorst-de van der Schueren M. von Meyenfeldt G. Zürcher R. Fietkau E. Aulbert B. Frick M. Holm M. Kneba H.J. Mestrom A. Zander | 2006 | Clinical Nutrition2006，，2： | 6 |
| 5 | TALGO BT型可变轨距内燃动车显示文摘西班牙的TALGO公司和德国的Krauss Maffei公司合作 ,为已运用了几十年之久的可变轨距式TALGO列车开发了TALGOBT型可变轨距的动力头车 (简称动车 )。文中详细介绍了该动车的总体布置、编组形式、司机室布置、变轨原理与过程、走行部布置以及制动系统等 。 | Carl-Peter Zander 王秀丽 韩才元 | 2001 | 国外内燃机车2001，，2： | 5 |
| 6 | Knowledge of the Firm, Combinative Capabilities, and the Replication of Technology显示文摘 | Bruce Kogut Udo Zander | 1992 | Organization Science1992，，3： | 4 |
| 7 | Performance of optimum transmitter power control in cellular radio systems显示文摘 | ZANDER J | 1992 | IEEE Trans Veh Technol1992，41，1： | 2 |
| 8 | Hypoxia-reoxygenation-induced apoptosis in cultured adult rat myocytes and the protective effect of platelets and transforming growth factor-beta ( 1 ) 显示文摘 | Yang BC Zander DS Mehta JL | 1999 | J Pharmacol Exp Ther1999，291，2： | 2 |
| 9 | What Firms Do? Coordination, Identity, and Learning显示文摘 | Bruce Kogut Udo Zander | 1996 | Organization Science1996，，5： | 2 |
| 10 | Silica-coating-assisted nitridation of TiO_(2) nanoparticles and their photothermal property显示文摘Nanoparticles of refractory compounds represent a class of stable materials showing a great promise to support localized surface plasmon resonances(LSPRs)in both visible and near infrared(NIR)spectral regions.It is still challenging to rationally tune the LSPR band because of the difficulty to control the density of charge carriers in individual refractory nanoparticles and maintain the dispersity of nanoparticles in the processes of synthesis and applications.In this work,controlled chemical transformation of titanium dioxide(TiO_(2))nanoparticles encapsulated with mesoporous silica(SiO_(2))shells to titanium nitride(TiN)via nitridation reaction at elevated temperatures is developed to tune the density of free electrons in the resulting titanium-oxide-nitride(TiO_(x)N_(y))nanoparticles.Such tunability enables a flexibility to support LSPR-based optical absorption in the synthesized TiO_(x)N_(y)@SiO_(2) core-shell nanoparticles across both the visible and NIR regions.The silica shells play a crucial role in preventing the sintering of TiO_(x)N_(y) nanoparticles in the nitridation reaction and maintaining the stability of TiOxNy nanoparticles in applications.The LSPR-based broadband absorption of light in the TiO_(x)N_(y)@SiO_(2) nanoparticles exhibits strong photothermal effect with photo-to-thermal conversion efficiency as high as〜76%. | Qilin Wei Danielle L.Kuhn Zachary Zander Brendan G.DeLacy Hai-Lung Dai Yugang Sun | 2021 | Nano Research2021，14，9： | 2 |
| 11 | 带烧结金属衬层闸瓦制动器的运用经验显示文摘叙述了运用闸瓦制动器的可行性 ,对其优、缺点进行了比较并指出了这些制动器的物理界限。此外 ,还总结了在 1 0 0多台机车上获得的运用经验。 | Carl-Peter Zander 钟连泉 | 2002 | 国外机车车辆工艺2002，，5： | 2 |
| 12 | Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPAR gamma显示文摘 | Zander T Kraus JA Grommes C | 2002 | J Neurochem2002，81，： | 2 |
| 13 | Knowledge of The Firm, Combinative Capabilities, and the Replication of Technology显示文摘 | Kogut B Zander U | 1992 | Organization Science1992，3，3： | 1 |
| 14 | Knowledge and the Speed of the Transfer and Imitation of Organizational Capabilities:an Empirical test显示文摘 | Zander U Kogut B | 1995 | Organi-zation Science1995，，6： | 1 |
| 15 | Knowledge of the Firm and Evolutionary The- ory of the Multinational Corporation 显示文摘 | Kogut B Zander U | 2003 | Journal of International Business Studies2003，26，4： | 1 |
| 16 | Corrosion resistance of Cu-Zr-Al-Y and Zr-Cu-Ni-Al-Nb bulk metallic glasses显示文摘 | Zander D Heisterkamp B Gallino I | 2007 | J Alloys Compd2007，，： | 1 |
| 17 | Knowledge of the firm, combinative capabilities, and the replication of technology 显示文摘 | Kogut B Zander U | 1992 | Organization Science1992，3，3： | 1 |
| 18 | WISC-III index score profiles of 520 Swedish children with pervasive developmental disorders显示文摘 | Zander E Dahlgren SO | 2010 | Psychol Assess2010，22，2： | 1 |
| 19 | Knowledge and the speed of the transfer and imitation of organizational capabilities: an empirical test 显示文摘 | Zander U Kogut B | 1995 | Organization Science1995，，6： | 1 |
| 20 | Knowledge and the speed of the transfer and imitation of organizational capabilities: an em- pirical test显示文摘 | ZANDER U KOGOUT B | 1995 | Organization Science1995，6，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员