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您的检索式：作者名="Varinder S"
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| 1 | Microwave accelerated preparation of HSO4 ionic liquid: an acid catalyst for improved synthesis of coumarlns 显示文摘 | Vasundhara S Sukhbir K Varinder S | 2005 | Catalysis Communications2005，6，1： | 1 |
| 2 | Non-alcoholic fatty liver disease in irritable bowel syndrome:More than a coincidence?显示文摘Irritable bowel syndrome(IBS)and non-alcoholic fatty liver disease(NAFLD)are amongst the most common gastrointestinal and liver conditions encountered in primary and secondary care.Recently,there has been interest in the apparent coincidence of NAFLD in patients with IBS mainly driven by improved understanding of their shared risk factors and pathophysiology.In this paper we summarize the shared risk factors which include;overlapping nutritional and dietary factors as well as shared putative mechanisms of pathophysiology.These include changes in the gut microbiome,gut permeability,immunity,small bowel bacterial overgrowth and bile acid metabolism.This paper describes how these shared risk factors and etiological factors may have practical clinical implications for these highly prevalent conditions.It also highlights some of the limitations of current epidemiological data relating to estimates of the overlapping prevalence of the two conditions which have resulted in inconsistent results and,therefore the need for further research.Early recognition and management of the overlap could potentially have impacts on treatment outcomes,compliance and morbidity of both conditions.Patients with known IBS who have abnormal liver function tests or significant risk factors for NAFLD should be investigated appropriately for this possibility.Similarly,IBS should be considered in patients with NAFLD and symptoms of abdominal pain associated with defecation,an altered bowel habit and bloating. | Huw Purssell Peter J Whorwell Varinder S Athwal Dipesh H Vasant | 2021 | World Journal of Hepatology2021，13，12： | 0 |
| 3 | COVID-19 and hepatorenal syndrome显示文摘Coronavirus disease 2019(COVID-19)is a highly infectious disease which emerged into a global pandemic.Although it primarily causes respiratory symptoms for affected patients,COVID-19 was shown to have multi-organ manifestations.Elevated liver enzymes appear to be commonly observed during the course of COVID-19,and there have been numerous reports of liver injury secondary to COVID-19 infection.It has been established that patients with pre-existing chronic liver disease(CLD)are more likely to have poorer outcomes following COVID-19 infection compared to those without CLD.Co-morbidities such as diabetes,hypertension,obesity,cardiovascular and chronic kidney disease frequently co-exist in individuals living with CLD,and a substantial population may also live with some degree of frailty.The mechanisms of how COVID-19 induces liver injury have been postulated.Hepatorenal syndrome(HRS)is the occurrence of kidney dysfunction in patients with severe CLD/fulminant liver failure in the absence of another identifiable cause,and is usually a marker of severe decompensated liver disease.Select reports of HRS following acute COVID-19 infection have been presented,although the risk factors and pathophysiological mechanisms leading to HRS in COVID-19 infection or following COVID-19 treatment remain largely unestablished due to the relative lack and novelty of published data.Evidence discussing the management of HRS in highdependency care and intensive care contexts is only emerging.In this article,we provide an overview on the speculative pathophysiological me-chanisms of COVID-19 induced HRS and propose strategies for clinical diagnosis and management to optimize outcomes in this scenario. | Henry H L Wu Varinder S Athwal Philip A Kalra Rajkumar Chinnadurai | 2022 | World Journal of Gastroenterology2022，28，39： | 0 |
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