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| 1 | Red blood cell distribution width in elderly hospitalized patients with cardiovascular disease显示文摘BACKGROUND Red blood cell distribution width(RDW)is elevated in patients with cardiovascular disease(CVD).AIM To determine RDW values and impact of CV and non-CV coexisting morbidities in elderly patients hospitalized with chronic CVD.METHODS This prospective study included 204 consecutive elderly patients(age 77.5[7.41]years,female 94[46%],left ventricular ejection fraction 53.00%[37.50,55.00])hospitalized with chronic CVD at the Cardiology Department of Larissa University General Hospital(Larissa,Greece)from January 2019 to April 2019.Elderly patients were selected due to the high prevalence of coexisting morbidities in this patient population.Hospitalized patients with acute CVD(acute coronary syndromes,new-onset heart failure[HF],and acute pericarditis/myocarditis),primary isolated valvular heart disease,sepsis,and those with a history of blood transfusions or cancer were excluded.The evaluation of the patients within 24 h from admission included clinical examination,laboratory blood tests,and echocardiography.RESULTS The most common cardiac morbidities were hypertension and coronary artery disease,with acutely decompensated chronic heart failure(ADCHF)and atrial fibrillation(AF)also frequently being present.The most common non-cardiac morbidities were anemia and chronic kidney disease followed by diabetes mellitus,chronic obstructive pulmonary disease,and sleep apnea.RDW was significantly elevated 15.48(2.15);121(59.3%)of patients had RDW>14.5%which represents the upper limit of normal in our institution.Factors associated with RDW in stepwise regression analysis were ADCHF(coefficient:1.406;95%confidence interval[CI]:0.830-1.981;P<0.001),AF(1.192;0.673 to 1.711;P<0.001),and anemia(0.806;0.256 to 1.355;P=0.004).ADCHF was the most significant factor associated with RDW.RDW was on average 1.41 higher for patients with than without ADCHF,1.19 higher for patients with than without AF,and 0.81 higher for patients with than without anemia.When patients were grouped based on the presence or absence of anemia,ADCHF and AF,heart rate was not increased in those with anemia but was significantly increased in those with ADCHF or AF.CONCLUSION RDW was elevated in elderly hospitalized patients with chronic CVD.Factors associated with RDW were anemia and CV factors associated with elevated heart rate(ADCHF,AF),suggesting sympathetic overactivity. | Andrew Xanthopoulos Konstantinos Tryposkiadis Apostolos Dimos Angeliki Bourazana Alexandros Zagouras Nikolaos Iakovis Michail Papamichalis Grigorios Giamouzis George Vassilopoulos John Skoularigis Filippos Triposkiadis | 2021 | World Journal of Cardiology2021，13，9： | 13 |
| 2 | BRCA1 affects global DNA methylation through regulation of DNMT1显示文摘在 CpG 岛的全球 DNA hypomethylation 结合了本地 hypermethylation 是为乳癌的一个特点,然而,位于这个变化下面的机制留下逃犯。在这研究,我们证明 DNMT1,编码 methylation 维护酶,是 BRCA1 的一个 transcriptional 目标。BRCA1 通过一个潜在的 OCT1 地点和绑定绑在 DNMT1 基因的倡导者为维持 transcriptional 被要求在老鼠和人的房间的倡导者的活跃配置。我们进一步证明 BRCA1 的那损害功能在在 premaligant 阶段在一个 BRCA1 变异的老鼠模型检验的纸巾的几种类型导致全球 DNA hypomethylation,印的 genomic 的损失,和一种开的染色质配置。BRCA1 缺乏也与几 protooncogenes 的显著地增加的表达式层次被联系,包括 c-Fos,哈地岬,和 c-Myc,与在肿瘤的一个更高的表达式,当时乳房的上皮的房间显示了的 premalignant 在肿瘤和控制之间的一个中间的状态。在人的临床的样品,有 DNMT1 的减少的层次的 BRCA1 相互关联的减少的表示,和 CpG 岛的减少的 methylation。因此, BRCA1 通过断然调整 DNMT1 表示阻止全球 DNA hypomethylation,并且这为联系 BRCA1 的乳癌形成提供机制之一。 | Vivek Shukla Xavier Coumoul Tyler Lahusen Rui-Hong Wang Xiaoling Xu Athanassios Vassilopoulos Cuiying Xiao Mi-Hye Lee Yan-Gao Man Mutsuko Ouchi Toru Ouchi Chu-Xia Deng | 2010 | Cell Research2010，20，11： | 5 |
| 3 | SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress显示文摘 | Hyun-Seok Kim Krish Patel Kristi Muldoon-Jacobs Kheem S. Bisht Nukhet Aykin-Burns J. Daniel Pennington Riet van der Meer Phuongmai Nguyen Jason Savage Kjerstin M. Owens Athanassios Vassilopoulos Ozkan Ozden Seong-Hoon Park Keshav K. Singh Sarki A. Abdulka | 2010 | Cancer Cell2010，，1： | 3 |
| 4 | Solitary fibrous tumor of the liver expressing CD34 and vimentin:A case report显示文摘A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported.An 82-year-old female presented with left upper abdominal discomfort,a firm mass on palpation,and imaging studies revealed a large tumor,15 cm in diameter,arising from the left lobe of the liver.A formal left hepatectomy was performed.Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 and positive vimentin,supporting the diagnosis of a benign SFT.The patient remained well 21 months after surgery.SFT of the liver is a very rare neoplasm of mesenchymal origin.In most cases it is a benign lesion,although some may have malignant histological features and recur locally or metastasize.With less than 30 reported cases in the literature,little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy.Complete surgical resection remains the cornerstone of its treatment. | Dimitris P Korkolis Katerina Apostolaki Chrysanthi Aggeli George Plataniotis Emmanuel Gontikakis Dimitra Volanaki Maria Sebastiadou Dimitris Dimitroulopoulos Dimitris Xinopoulos George N Zografos Perikles P Vassilopoulos | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 5 | Sustained Responses and Loss of HBsAg in HBeAg-Negative Patients With Chronic Hepatitis B Who Stop Long-Term Treatment With Adefovir显示文摘 | Stephanos J. Hadziyannis Vassilios Sevastianos Irene Rapti Dimitrios Vassilopoulos Emilia Hadziyannis | 2012 | Gastroenterology2012，，3： | 2 |
| 6 | Hepatitis B e antigen—negative chronic hepatitis B显示文摘 | Stephanos J. Hadziyannis Dimitrios Vassilopoulos | 2001 | Hepatology2001，，4： | 2 |
| 7 | Comparing imagery and verbal instructions for the experimental modification of interpretation and judgmental bias in children显示文摘 | Stephanos P Vassilopoulos Simon E Blackwell Nicholas J Moberly Eleni Karahaliou | | 0，，01： | 1 |
| 8 | Anticipatory processing plays a role in main- taining social anxiety 显示文摘 | Vassilopoulos SPH | 2005 | Anxiety Stress Coping2005，18，4： | 1 |
| 9 | Safety of antitumour necrosis factor (anti-TNF) therapy in patients with chronic viral infections: hepatitis C, hepatitis B, and HIV infection显示文摘 | Calabrese LH Zein N Vassilopoulos D | 2004 | Ann Rheum Dis2004，63，2： | 1 |
| 10 | SIRT2 maintains ge- nome integrity and suppresses tumorigenesis through regulating APC/C activity显示文摘 | Kim H S Vassilopoulos A Wang R H | 2011 | Cancer Cell2011，20，4： | 1 |
| 11 | A total fatigue life model for the prediction of the R-ratio effects on fatigue crack growth of adhesively-bonded pultrudcd GFRP DCB joints显示文摘 | Shahvcrdi M Vassilopoulos A Keller T | 2012 | Composites Part A: Applied Science and Manufacturing2012，43，10： | 1 |
| 12 | Update of the role of surgery in the multimodal treatment of MALT gastric lymphoma 显示文摘 | Kelessis NG Vassilopoulos PP Bai MP | 2002 | Anticancer Res2002，22，6： | 1 |
| 13 | Prevention of atrial fibrillation by interatrial septum pacing guided by electrophysiological testing, in patients with delayed interatrial conduction 显示文摘 | Manolis AG Katsivas AG Vassilopoulos C | 2002 | Europace2002，4，： | 1 |
| 14 | Update of the role of surgery in the multimodal treatment of MALT gastric lym- phomas显示文摘 | Kelessis N G Vassilopoulos P P Bai M P | 2002 | Anticancer Res2002，22，6： | 1 |
| 15 | Regulation of MnSOD enzymatic activity by Sift3 connects the mito- chondrial acetylome signaling networks to aging and carci- nogenesis 显示文摘 | Tao R Vassilopoulos A Parisiadou L | 2014 | Antioxid Redox Signal2014，20，10： | 1 |
| 16 | Angioimmunobiastic T-cell lymphoma-associated arthritis: case report and literature review显示文摘 | Tsoehatzis E Vassilopoulos D Deutseh M | 2005 | J Clin Rlaettmatol2005，11，6： | 1 |
| 17 | Update of the role of surgery in the multimodal treatment of MALT gastric lymphoma显示文摘 | Kelessis NG Vassilopoulos PP Bai MP | 2002 | Anticancer Res2002，22，： | 1 |
| 18 | Transplanted bone marrowregenerates liver by cell fusion显示文摘 | Vassilopoulos G Wang P R Russell D W | 2003 | Nature2003，422，： | 1 |
| 19 | The combined evaluation of p27kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients显示文摘 | Korkolopoulou P Vassilopoulos I Konstantinidou AE | 2002 | Gynecol Oncol2002，85，3： | 1 |
| 20 | Ship rolling at zero speed in random beam seas显示文摘 | Vassilopoulos L A | 1971 | JSR1971，15，： | 1 |
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