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| 1 | Correlation between KCNQ1 and KCNJ11 gene polymorphisms and type 2 and posttransplant diabetes mellitus in the Asian Indian population显示文摘Type 2 diabetes mellitus(T2DM)and post-transplant diabetes mellitus(PTDM)share a common pathophysiology.However,diabetes mellitus is a complex disease,and T2DM and PTDM have different etiologies.T2DM is a metabolic disorder,characterized by persistent hyperglycemia,whereas PTDM is a condition of abnormal glucose tolerance,with variable onset after organ transplant.The KCNQ1 and KCNJ11 gene encode potassium channels,which mediate insulin secretion from pancreatic b-cells,and KCN gene mutations are correlated with the development of diabetes.However,no studies have been carried out to establish an association between KCNQ1 and KCNJ11 gene polymorphisms and T2DM and PTDM.Therefore,our study was aimed at the identification of the role of KCNQ1 and KCNJ11 gene polymorphisms associated with T2DM and the risk of developing PTDM in the Asian Indian population.We have carried out a caseecontrol study including 250 patients with T2DM,250 control subjects,42 patients with PTDM and 98 subjects with non-PTDM.PCR-RFLP analysis was carried out following the isolation of genomic DNA from EDTA-blood samples.The results of the present study reveal that two single nucleotide polymorphisms(rs2283228 and rs5210,of the KCNQ1 and KCNJ11 genes,respectively)are associated with both T2DM and PTDM.The results of our study suggest a role of KCNQ1 and KCNJ11 gene variants in the increased risk of T2DM and PTDM in the Asian Indian population. | Imran Ali Khan Kiran Kumar Vattam Parveen Jahan Kamal Kiran Mukkavali Qurratulain Hasan Pragna Rao | 2015 | Genes & Diseases2015，2，3： | 6 |
| 2 | Cognitive, collaborative, conceptual and creative -- four characteristics of the next generation of knowledge-based CAD systems:a study in biologically inspired design 显示文摘 | GOEL A K VATTAM S WILTGEN B | 2012 | Computer-Aided Design2012，40，10： | 1 |
| 3 | Mutations in the human dehasarcoglycan gene in familial and sporadic dilated cardiomyopathy 显示文摘 | Tsubata S Bowles KR VattaM | 2000 | J Clin Invest2000，106，： | 1 |
| 4 | Cognitive, Col- laborative, Conceptual and Creative: Four Characteristics of the Next Generation of Knowledge-based CAD Systems: a Study in Biologically Inspired Design显示文摘 | GOEL A K VATTAM S WILTGEN B | 2011 | Computer-Aided De- sign2011，44，： | 1 |
| 5 | Understanding Complex Natural Systems by Articulating Structure-behavior-function Models显示文摘 | VATTAM S GOEL A K RUGABER S | 2011 | Educational Technology & Society2011，14，1： | 1 |
| 6 | Cognitive, collaborative, conceptual and creative-four characteristics of the next generation of knowledge-based CAD systems: a studying biologically inspired design 显示文摘 | Goel A K Vattam S Wiltgen B | 2012 | Computer-Aided Design2012，40，10： | 1 |
| 7 | Biologically in-spired design: process and products 显示文摘 | HELMS M VATTAM S GOEL A | 2009 | Design Stud-ies2009，30，5： | 1 |
| 8 | Cognitive, collaborative, conceptual and creative -- four char- acteristics of the next generation of knowledge-based CAD systems: A study in biologically inspired design 显示文摘 | GOEL A K VATTAM S WILTGEN B | 2012 | Computer-Aided Design2012，44，10： | 1 |
| 9 | Biologically in- spired design: Process and products 显示文摘 | HELMS M VATTAM S S GOEL A K | 2009 | Design Stud- ies2009，30，5： | 1 |
| 10 | A content ac- count of creative analogies in biologically inspired de- sign 显示文摘 | VATTAM S S HELMS M E GOEL A K | 2010 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2010，24，4： | 1 |
| 11 | Cognitive,collaborative,conceptual and creative-Four characteristics of the next generation of knowledge-based CAD systems:a study in biologically inspired design显示文摘 | Goel A K Vattam S Wiltgen B | 2012 | Computer-Aided Design2012，44，10： | 1 |
| 12 | Structure, behavior and function of complex systems: the SBF modeling language 显示文摘 | Goel A Rugaber S Vattam S | 2009 | International Journal of AI in Engineering Design Analysis and Manufacturing Special Issue on Developing and Using Engineering Ontologies2009，23，： | 1 |
| 13 | Structure, behavior, and function of complex systems : The structure, be- havior, and function modeling language 显示文摘 | Ashok K Goel Spencer Rugaber Vattam Swaroop | 2009 | Ai Edam2009，23，1： | 1 |
| 14 | Cognitive, Collaborative, Conceptual and Creative: Four Characte- ristics of the Next Generation of Knowledge-based CAD Systems: a Study in Biologically Inspired Design显示文摘 | GOEL A K VATTAM S WILTGEN B | 2011 | Computer-Aided Design2011，44，： | 1 |
| 15 | Biologically Inspired Design显示文摘 | Helms M S.S. Vattam A.K.Goel | | 0，，05： | 1 |
| 16 | Cognitive,collabora- tive,conceptual and creative-four characteristics of the next generation of knowledge-based CAD systems:a study in bio- logically inspired design 显示文摘 | Goel A K Vattam S Wihgen B | 2012 | Computer-Aided Design2012，44，10： | 1 |
| 17 | Biologically inspired design: process and products 显示文摘 | Helms M Vattam S S Goel A K | 2009 | Design Studies2009，30，5： | 1 |
| 18 | Biologically inspired de-sign: process and products显示文摘 | Helms M Vattam S S Goel A K | 2009 | Design Studies2009，30，5： | 1 |
| 19 | Management of painful vertebral hemangiomas with kyphoplasty:a report of two cases and a literature review显示文摘 | Jones JO Bruel BM Vattam SR | | 0，，： | 1 |
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