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| 1 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 2 | Glucosinolate hydrolysis products from various plant sources : pH effects, isolation, and purification 显示文摘 | VAUGHN S F BERHOW M A | 2005 | Industrial Crops and Products2005，21，2： | 1 |
| 3 | Seasonal variations in plant species effects on soil N and P dynamics显示文摘 | EVINER V T CHAPIN F S VAUGHN C E | 2006 | Ecology2006，87，： | 1 |
| 4 | Does preoperative anxiety level predict postoperative pain 显示文摘 | Vaughn F Wichowski H Bosworth G | 2007 | AORN J2007，85，3： | 1 |
| 5 | Essential oils enhanced by ultra--high carbon dioxide levels from Lamiaceae species grown in vitro and in vivo显示文摘 | B Tisserat S F Vaughn | 2001 | Plant Cell Reports2001，，20： | 1 |
| 6 | The detrimental effects of delayed graft function in cadaver donor renal transplantation显示文摘 | Sanfilippo F Vaughn WK Spees EK | 1984 | Transplantation1984，38，6： | 1 |
| 7 | Density-Dependent Natural Selection in Drosophila:Evolution of Pupation Height显示文摘 | Mueller Laurence D Sweet Vaughn F | 1986 | Evolution1986，40，6： | 1 |
| 8 | Lipoxygenase-derived aldehydes inhibit fungi pathogenic on soybean 显示文摘 | Vaughn S F Gardner H W | 1993 | J Chem Ecol1993，19，10： | 1 |
| 9 | Epigenetic reprogramming and small RNA silencing of transposable elements in pollen显示文摘 | Slotkin RK Vaughn M Borges F | 2009 | Cell2009，136，3： | 1 |
| 10 | Allelochemicals isolated from tissues of the invasive weed garlic mustard (Alliaria petiolata) 显示文摘 | VAUGHN S F BERHOW M A | 1999 | Journal of Chemical Ecology1999，25，： | 1 |
| 11 | The detrimental effects of delayed graft function in cadaver donor renal transplantation 显示文摘 | Sanfilippo F Vaughn WK Speese EK | 1984 | Transplantation1984，38，5： | 1 |
| 12 | Epigenetic reprogramming and small RNA silencing of transposable elements in pollen显示文摘 | SLOTKIN R K VAUGHN M BORGES F | 2009 | Cell2009，136，3： | 1 |
| 13 | Glutamine-glutamate exchange between placenta and fetal liver显示文摘 | Vaughn P R Lobo C Battaglia F C | 1995 | American Journal of Physiology Endocrinology and Metabolism1995，268，： | 1 |
| 14 | Allelochemicals isolated from tissues of the invasive weed garlic mustard (Alliaria petiolata)显示文摘 | Vaughn S F Berhow M A | 1999 | Journal of Chemical Ecology1999，，25： | 1 |
| 15 | Epigeneti c reprogramming and small RNA silencing of transpos-able elements in pollen显示文摘 | SLOTKIN RK VAUGHN M BORGES F | 2009 | Cell2009，136，： | 1 |
| 16 | Behavioral and physiological responses of Diaeretiella rapae to semiochemicals显示文摘 | VAUGHN T T ANTOLIN M F BJOSTAD L B | 1996 | Entomologia Experimentalis et Applicata1996，78，2： | 1 |
| 17 | Does preoperative anxiety level predict postoperative pain显示文摘 | Vaughn F Wichowski H Bosworth G | 2007 | AORN J2007，85，3： | 1 |
| 18 | Evaluation of Biodiesels from Several Oilseed Sources as Environmental Friendly Contact Herbicides 显示文摘 | STEVEV F VAUGHN RONALD A H | 2007 | Industrial Crops and Products2007，26，： | 1 |
| 19 | Allelochemicals isolated from tissues of the invasive weed garlic mustard (Alliaria petiolata)显示文摘 | Vaughn S F Berhow M A | 1999 | Journal of Chemical Ecology1999，25，11： | 1 |
| 20 | Reduced graft rejection with good HLA-A and B matching in high-risk corneal transplantation 显示文摘 | Sanfilippo F MacQueen JM Vaughn WK | 1986 | N Engl J Med1986，315，1： | 1 |
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