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| 1 | How to Make Capsules Containing Rejuvenators for Their Use in Asphalt Concrete显示文摘Rejuvenators are products designed to restore original properties to oxidized asphalt binders by restoring the original ratio of asphaltenes to maltenes. But,for a rejuvenator to be successful,it must penetrate the pavement surface. Besides,application of a rejuvenator will also reduce the skid resistance of the pavement. To solve this,these rejuvenators can be encapsulated and mixed in asphalt concrete. Once the stress in the capsules reaches a certain threshold,the particles break and the rejuvenator is released,giving back the original properties of the pavement. The objective of this paper is to show how these capsules behave and define the most appropriate testing methods to find their effect on asphalt concrete. For this,two different types of rejuvenators will be encapsulated and their effect on the properties of the capsules investigated. Besides,the release mechanisms of the capsules will be unravelled. | GARCIA A SCHLANGEN E VAN DE VEN M F C | 2010 | 武汉理工大学学报2010，32，17： | 7 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | WONCA研究论文摘要汇编——初级医疗连续性服务及其与老年人生存的关系:一项17年的前瞻性队列研究显示文摘背景尽管连续性服务在基层医疗中是被广泛接受的核心原则,但是关于其优势的证据仍然不足。目的探讨全科医学中连续性服务是否与老年人长寿相关。设计与场所数据来源于阿姆斯特丹纵向衰老研究,对荷兰老年人进行不间断队列研究。研究样本包括1 712例年龄≥60岁的老年人,进行3年随访,周期长达17年,随访其死亡率直至2013年。方法连续性服务被定义为患者和全科医生之间不间断的治疗关系的持续过程。采用赫芬达尔-赫希曼指数计算服务的连续性(COC)。COC指数为1代表最大连续性。将COC指数〈1的患者分为3组,COC最大值的参与者为第4组。采用Cox回归分析探讨COC和存活时间之间的关联。结果 742例参与者(43.3%)COC取得最大值。在生存17年的759例参与者中,251例(33.1%)仍有相同的全科医生服务。COC最小值组(指数〉0~0.500)死亡率高于COC最大值组,差异有统计学意义〔HR=1.20,95%CI(1.01,1.42)〕。目前无混杂因素影响该HR。结论该研究表明全科医学中低连续性服务与高死亡风险相关,应强化该案例以鼓励连续性服务。 | MAARSINGH O R HENRY Y VAN DE VEN P M 本刊编辑部 | 2016 | 中国全科医学2016，19，27： | 4 |
| 4 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 5 | Stability of Ground and Precipitated CaCO3 Suspensions in the Presence of Polyethylene Oxide and Kraft Lignin显示文摘 | Cechova M Alince B T G M van de Ven | 1998 | Collids and Surfaces A:Physicochemical and Engineering Aspects1998，，141： | 1 |
| 6 | Explaining development and change in organizations 显示文摘 | Van de Ven AH Poole M S | 1995 | Academy of Management Review1995，20，3： | 1 |
| 7 | Delayed surgical treatmentof supracondylar humerus fractures in children using a me-dial approach显示文摘 | Eren A Güven M Erol B | 2008 | J Child Orthop2008，2，1： | 1 |
| 8 | Oral Decontam- ination with Chlorhexidine Reduces the Incidence of Ven- tilator-associated Pneumonia显示文摘 | Koeman M Van Der Ven A Hak E | 2006 | Am J Resp Cri Care Med2006，173，12： | 1 |
| 9 | Exposure to tetrabromobisphenol A (TBBPA) in Wistar rats: neurobehavioral effects in offspring from a one - generation reproduction study 显示文摘 | Lilienthal H Verwer C M Van der Ven T M | 2008 | Toxicology2008，246，1： | 1 |
| 10 | Charac- teristics of two-component epoxy modified bitumen 显示文摘 | Xiao Y van de Ven M F C Molenaar A A A | 2010 | Ma- ter Struct2010，44，： | 1 |
| 11 | The effect of calcium ions on the efficiency of polyethylene oxide-cofactor retention aid systems显示文摘 | Van de Ven T G M Qasaimeh M A Pigeon C | 2007 | Colloids Sur:2007，297，1： | 1 |
| 12 | Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia显示文摘 | Koeman M van der Ven AJ Hak E | 2006 | Am J Respir Crit Care Med2006，173，12： | 1 |
| 13 | Explaining development and change in organizations 显示文摘 | VAN DE VEN A H POOLE M S | 1995 | Academy of Management Review1995，，20： | 1 |
| 14 | Explaining Development and Change in Organizations显示文摘 | POOLE M S | 1995 | Academy of Management Review1995，20，3： | 1 |
| 15 | Rats' preferences for corn versus wood-based bedding and nesting material显示文摘 | Ras T Ven M Patterson EG | 2002 | Lab Anim2002，36，4： | 1 |
| 16 | Investiga- ting the self healing capability of bituminous binders 显示文摘 | Qiu J Van de Ven M F C Wu S | 2009 | Road Materials and Pavement Design2009，，： | 1 |
| 17 | First-Prlnciples Theory of Ionic Diffusion with Nondilute Carriers显示文摘 | Van der Ven A Ceder G Asta M | 2001 | Physical Review B2001，，18： | 1 |
| 18 | Hollow fi- ber dead-end ultrafiltration: influence of ionic environment on filtrationofalginates 显示文摘 | van de Ven W J C Sant van't K Pant I G M | 2008 | J Membr Sci2008，308，12： | 1 |
| 19 | Myotilin, the limb-girdle muscular dystrophy I A (LGMD1A) protein, cross- links actin filaments and controls sarcomere assembly显示文摘 | Salmikangas P van der Ven PF Lalowski M | 2003 | Hum Mol Genet2003，12，： | 1 |
| 20 | Endocrine effects of tetrabromobisphenol - A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study 显示文摘 | Van der Ven L T M De Kuil T V Verhoef A | 2008 | Toxicology2008，245，12： | 1 |
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