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| 1 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 2 | Evaluating character partitioning and molecular models in plastid phylogenomics at low taxonomic levels:A case study using Amphilophium(Bignonieae,Bignoniaceae)显示文摘The accurate analyses of massive amounts of data obtained through next-generation sequencing depend on the selection of appropriate evolutionary models.Many plastid phylogenomic studies typically analyze plastome data as a single partition,or divided by a region,using a concatenate“supergene”approach.The effects of molecular evolutionary models and character partition strategies on plastome-based phylogenies have generally been evaluated at higher taxonomic levels in green plants.Using plastome data from 32 species of Amphilophium,a genus of Neotropical lianas,we explored potential sources of topological incongruence with different plastid genome datasets and approaches.Specifically,we evaluated the effects of compositional heterogeneity,codon usage bias,positive selection,and incomplete lineage sorting as sources of systematic error(i.e.,the recovery of well-supported conflicting topologies).We compared different datasets(e.g.,non-coding regions,exons,and codon-aligned and translated amino acids)using concatenated approaches under site-heterogeneous and site-homogeneous models,as well as multispecies coalescent(MSC)methods.We found incongruences in recovered phylogenetic relationships,which were mainly located in short internodes.The MSC and concatenated approaches recovered similar topologies.The analysis of GC content and codon usage bias indicated higher substitution rates and AT excess at the third codon positions,and we found evidence of positive selection in 3%of amino acid sites.There were no significant differences among species in site biochemical profiles.We argue that the selection of appropriate partition strategies and evolutionary models is important to increase accuracy in phylogenetic relationships,even when using plastome datasets,which is still the primarily used genome in plant phylogenetics. | Verônica A.Thode Lúcia G.Lohmann Isabel Sanmartín | 2020 | Journal of Systematics and Evolution2020，58，6： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement显示文摘Hepatocellular carcinoma(HCC) is the most frequent form of liver cancer and the third most common cause of cancer-related death in the world. The main risk factor worldwide for this type of malignancy is chronic hepatitis caused by hepatitis B virus and hepatitis C virus infections. Advances in early detection and treatmenthave improved life expectancy of patients with HCC. However, this disorder remains as a disease with poor prognosis. In fact, epidemiological studies have revealed that there is an 8-mo median survival rate in patients, approximately 20% of whom survive one year while only 5% remain alive after three years. Additionally, HCC is particularly difficult to treat because of its high recurrence rate, and its resistance to conventional chemotherapy is due, among other mechanisms, to several members of the ATP-Binding Cassette protein family involved in drug transport being overexpressed. Fortunately, there is evidence that these patients may benefit from alternative molecular-targeted therapies. This manuscript intends to provide further insight into the etiology and molecular mechanisms related to HCC development and the latest therapeutic approaches to treat this malignancy. The development of effective delivery systems of antitumor drugs able to target the liver parenchyma is also assessed. Finally, the prospects in the development of more efficient drug therapies to overcome multidrug resistance are also examined. | María L Cuestas José R Oubia Verónica L Mathet | 2015 | World Journal of Pharmacology2015，4，1： | 2 |
| 5 | Spatial hetero-geneity in eight central Texas grasslands显示文摘 | Miller R E Ver Hoe J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 6 | Genetic heterogeneity of G and F protein genes from Argentinean human metapneumovirus strains显示文摘 | Galiano M Trento A Ver L | 2006 | J Med Virol2006，78，5： | 1 |
| 7 | Interactions of C, N, P and S biogeochemical cycles and global change显示文摘 | Mackenzie F T Ver L M Sabine C | 1993 | NATO ASI1993，4，1： | 1 |
| 8 | Spatial heterogeneity in eight central Texas grasslands 显示文摘 | Ver Hoef J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 9 | Coordinate induction of PPARa and SREBP2 in muhifunctional protein 2 defi- cient mice显示文摘 | Martens K Ver L Themaat E | 2008 | Biochim Biophys Acta2008，1781，1112： | 1 |
| 10 | Serologic survey for canine coronavirus in wolves from Alaska显示文摘 | Zarnke R L Evermann J Ver Hoef J M | 2001 | J Wildlife Dis2001，37，： | 1 |
| 11 | Spatial heterogeneity in eight central Texas grasslands显示文摘 | Miller R E Ver H J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 12 | Arabidopsis and the Heat Stress Transcription Factor World: How Many Heat Stress Transcription Factors do we Need显示文摘 | N()VER L BHARTI K D RING P | 2001 | Cell Stress Chaperones2001，6，3： | 1 |
| 13 | Sunflower seed shells: A novel and effective low-cost adsorbent for the removal of the diazo dye Reactive Black 5 from aqueous solutions显示文摘 | Johann F O Ver′onica S Jos′e L | 2007 | Journal of Hazardous Materials2007，147，3： | 1 |
| 14 | The descriptive epi- demiology of obsessive compulsive disorder 显示文摘 | Fontenelle L F Mendlowicz MV Ver siani M | 2006 | Prog Neuropsy- chopharmacol Biol Psychiatry2006，30，3： | 1 |
| 15 | Myostatin levels in regenerating rat muscles and in myogenic cell cultures显示文摘 | Mendler L Zador E Ver Heyen M | 2000 | J Muscle Res Cell Motil2000，21，6： | 1 |
| 16 | Myostatin levels in regenerating rat muscles and in myogenic cell cultures显示文摘 | Mendler L Zador E Ver Heyen M | | 0，，06： | 1 |
| 17 | Coastal-zone biogeoehemical dynamics under global warming显示文摘 | MACKENZIE F T VER L M LERMAN A | 2000 | International Geology Review2000，42，3： | 1 |
| 18 | Magnetic Resonance Imaging of Cartilage and Cartilage Repair 显示文摘 | Ver st raete K L Almqvist F | 2004 | Clinical Radiology2004，59，： | 1 |
| 19 | Spatial heterogeneity in eight central Texas grasslands显示文摘 | Miller R E Ver Hoef J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 20 | Cross-species trans- mission of honey bee viruses in associated arthropods 显示文摘 | Levitt A L Singh R Cox-Foster D L Rajotte E Hoo- ver K Ostiguy N Holmes E C | 2013 | VirusRes2013，176，： | 1 |
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