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| 1 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 2 | Autophagy, apoptosis and organelle features during cell exposure to cadmiumč显示文摘Cadmium(Cd)induces several effects in different tissues,but our knowledge of the toxic effects on organelles is insuffi cient.To observe the progression of Cd effects on organelle structure and function,HuH-7 cells(human hepatic carcinoma cell line)were exposed to CdCl2 in increasing concentrations(1μM–20μM)and exposure times(2 h–24 h).During Cd treatment,the cells exhibited a progressive decrease in viability that was both time-and dose-dependent.Cd treated cells displayed progressive morphological changes that included cytoplasm retraction and nuclear condensation preceding a total loss of cell adhesion.Treatment with 10μM for 12 h led to irreversible damages.Before these drastic and irreparable damages,treated cells(5μM for 12 h)presented a progressive loss of mitochondrial function and cytoplasm acidifi cation as well as dysfunction and disorganization of microfi laments and endoplasmic reticulum.These damages led to the induction of apoptotic events and an increase in autophagic bodies in the cytoplasm.These results revealed that Cd affects multiple intra-cellular targets that induce alterations in the mitochondria,cytoskeleton,endoplasmic reticulum and acidic compartments,ultimately culminating in cell death via apoptotic and autophagic pathways. | CRISTIANE DOS SANTOS VERGILIO EDÉSIO JOSÉTENÓRIO DE MELO | 2013 | BIOCELL2013，37，2： | 2 |
| 3 | Recent advances in the understan- ding of Langerhans cell histiocytosis显示文摘 | Badalian-Very G Vergilio JA Degar BA | 2012 | Br J Haematol2012，156，2： | 1 |
| 4 | A symbolic fault-prediction model based on multiobjective particle swarm optimization 显示文摘 | De Carvalho A B Pozo A Vergilio S R | 2010 | Journal of Systems and Software2010，83，5： | 1 |
| 5 | Distribution of hemato- poietic stem cells in the bone marrow according to regional hypoxia 显示文摘 | Parmar K Mauch P Vergilio J A | 2007 | Proc Nail Acad Sci USA2007，104，13： | 1 |
| 6 | Distribution of hematopoi- etic stem cells in the bone marrow according to regional hypoxia 显示文摘 | Parmar K Maueh P Vergilio JA | 2007 | Proc Natl Acad Sci USA2007，104，13： | 1 |
| 7 | CD10 and BCL6 expression in the diagnosis of angioimmunoblastic T2cell lymphoma:utility of detecting CD10+ T cells by flow cytometry显示文摘 | Yuan CM Vergilio JA Zhao XF | 2005 | Hum Pathol2005，36，7： | 1 |
| 8 | Patho-genesis of Langerhans cell histiocytosis显示文摘 | Badalian -Very G Vergilio JA Fleming M | | 0，，： | 1 |
| 9 | Philadelphia-chromosome-positive acute myeloid leukemia:a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis显示文摘 | SOUPIR C P VERGILIO J A DAL CIN P | 2007 | Am J Clin Pathol2007，，： | 1 |
| 10 | Philadelphia chromosome-positive acute myeloid leukemia:a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis显示文摘 | SOUPIR C P VERGILIO J A CIN P D | 2007 | Am J Clin Pathol2007，127，： | 1 |
| 11 | CD10 and BCL6 expression in the diagnosis of angioimmunoblastic T-cell lymphoma: utility of detecting CD10+ T cells by flow cytometry显示文摘 | Yuan CM Vergilio JA Zhao XF | 2005 | Hum Pathol2005，36，： | 1 |
| 12 | CD10 and BCL6 expression in the diagnosis of angioimmunoblastic T-cell lymphoma: utility of detecting CD10 + T cells by flow cytometry显示文摘 | Yuan CM Vergilio JA Zhao XF | 2005 | Hum Pathol2005，36，7： | 1 |
| 13 | Pathogenesis of Langerhans cell histiocytosis显示文摘 | Badalian-Very G Vergilio JA Fleming M | 2013 | Annu Rev Pathol2013，8，： | 1 |
| 14 | Pathogenesis of Langerhans cell histiocytosis 显示文摘 | Badalian -Very G Vergilio JA Fleming M | 2013 | Annu Rev Pathol2013，8，： | 1 |
| 15 | Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia显示文摘 | Parmar K Mauch P Vergilio JA | 2007 | Proc Nail Acad Sci USA2007，104，13： | 1 |
| 16 | RecmTent BRAF mutations in Langerhans cell histiocytosis 显示文摘 | Badalian - Very G Vergilio JA Degar BA | 2010 | Blood2010，116，1： | 1 |
| 17 | Spindle cell mctaplasia of tile thyroid arising in association with papillary carinotna and follicular adenoma显示文摘 | Vergilio J Bahwh Z W LiVolsi V A | 2002 | Am J Clin Pathol2002，117，2： | 1 |
| 18 | Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia显示文摘 | Parmar K Mauch P Vergilio JA | | 0，，： | 1 |
| 19 | Recurrent BRAF muta-tions in Langerhans cell histiocytosis显示文摘 | Badalian-Very G Vergilio JA Degar BA | | 0，，11： | 1 |
| 20 | Philadelphia chromo- some-positive acute myeloid leukemia: a rare aggressive leukemia with clinieopathologic features distinct from chronicmyeloid leukemia in myeloid blast crisis 显示文摘 | Soupir CP Vergilio JA Dal Cin P | 2007 | Am J Clin Pathol2007，127，4： | 1 |
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