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| 1 | Smad3 knock-out mice as a useful model to study intestinal fibrogenesis显示文摘瞄准:为了在形态学和免疫评估可能的差别, CD3,转变生长因素 beta1 (TGF-beta1 ) , Smad7, alpha 光滑的肌肉肌动朊(alpha-Sma ) ,和骨胶原的组织化学的表示打 I-VII 小并且在 Smad3 空、野类型的老鼠的大肠。方法:十 0 和十只野类型的成年老鼠在年龄和机关的 4 瞬间被牺牲(食管,小、大的肠,输尿管) 为组织学被收集(苏木精和曙红,马森 thrichrome,染色的银) ,形态测定法和免疫组织化学分析。肠的织物 homogenates 的 TGF-beta1 层次被 ELISA 估计。结果:没有宏观的肠的损害在空、野类型的老鼠两个都被检测。组织学并且 morphometric 评估在肌肉层厚度揭示了重要减小小并且在空老鼠的大肠同样与野类型的老鼠相比。Immunohistochemistry 评估显示出染色在的 CD3+ T 房间, TGF-beta1 和 Smad7 的重要增加小并且 Smad3 空老鼠的大肠粘膜同样与野类型的老鼠相比。染色的 Alpha-Sma 和骨胶原 I-VII 小并且大肠没在二组老鼠之间不同。结肠的织物 homogenates 的 TGF-beta1 层次比在野类型的老鼠在空老鼠是显著地更高的。在初步的实验,导致 TNBS 的肠的纤维变性的重要减小作为与野类型的老鼠相比在空老鼠被观察。结论:Smad3 空老鼠是一个有用模型调查在肠的发炎和纤维变性表明小径的 TGF-beta/Smad 的在活体内角色。 | Giuliana Zanninelli Antonella Vetuschi Roberta Sferra Angela D'Angelo Amato Fratticci Maria Adelaide Continenza Maria Chiaramonte Eugenio Gaudio Renzo Caprilli Giovanni Latella | 2006 | World Journal of Gastroenterology2006，12，8： | 3 |
| 2 | Smad3-null mice lack interstitial cells of Cajal in the colonic wall显示文摘 | Vetuschi A Sferra R Latella G | 2006 | Eur J Clin Invest2006，36，1： | 1 |
| 3 | Determination of High-Frequency d-and q-axis Inductances for Surface-Mounted Permanent-Magnet Synchronous Machines显示文摘 | Lu K Vetuschi M Rasmussen P O Ritchie A E | | 0，，09： | 1 |
| 4 | Targeted disruption of Smad3 confers resistance to the development of dimethvlnitrosamine-induced hepatic fibrosis in mice显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Liver Intemational2009，29，7： | 1 |
| 5 | Determination of high- frequency d- and q-axis inductances for surface-mounted permanent- magnet synchronous machines 显示文摘 | LU K VETUSCHI M RASMUSSEN P O | 2010 | IEEE Transactions on Instrumen- tation and Measurement2010，59，9： | 1 |
| 6 | Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenz -ene sulphonic acid显示文摘 | Latella G Sferra R Vetuschi A | 2008 | Eur J Clin Invest2008，38，6： | 1 |
| 7 | Smad3 loss con- fers resistance to the development of trinitrobenzene sulfon- ic acid-induced colorectal fibrosis 显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Eur J Clin Invest2009，39，： | 1 |
| 8 | Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid- induced colorectal fibrosis显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Eur J Clin Invest2009，39，2： | 1 |
| 9 | Targeted disruptionof Smad3 confers resistance to the development of dime-thylnitrosamine-induced hepatic fibrosis in mice显示文摘 | Latella G Vetuschi A Sferra R | 2009 | LiverInt2009，29，7： | 1 |
| 10 | Targeted disnJp- tion of Smad3 confers resistance to the development of dimethylni- trosamine- induced hepatic fibrosis in mice显示文摘 | LATELLA G VETUSCHI A SFERRA R | 2009 | Liver lnt2009，29，7： | 1 |
| 11 | Prewention of colonic fibrosis by boswel ia and scutel aria extracts in rat with colitis induced by 2,4,5-triintorbenzsulphonic acid显示文摘 | Latel a G Sferra R Vetuschi A | | 0，，： | 1 |
| 12 | Simultaneous determination of lonidamine 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid,a new antitumoral,and its impurity,N2 substituted isomer,by UV derivative spectrophotometry显示文摘 | Vetuschi C Ragno G | 1989 | Anal Lett1989，22，7： | 1 |
| 13 | Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid 显示文摘 | Latella G Sferra R Vetuschi A | 2008 | Eur J Clin Invest2008，38，6： | 1 |
| 14 | Dextran sulfate sodium ( DSS ) colitis in rats : clinical, structural, and uhrastructural aspects显示文摘 | Gaudio E Taddei G Vetuschi A | 1999 | Dig Dis Sci1999，44，7： | 1 |
| 15 | Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats显示文摘 | VETUSCHI A LATELLA J A G SFERRA R | 2002 | Digestive Diseases and Sciences2002，47，7： | 1 |
| 16 | Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Eur J Clin Invest2009，39，2： | 1 |
| 17 | Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-in-duced hepatic fibrosis in mice显示文摘 | LATELLA G VETUSCHI A SFERRA R | 2009 | Liver Int2009，29，： | 1 |
| 18 | Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice 显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Liver Int2009，29，7： | 1 |
| 19 | Targeted disruption of Smad3confersresistance to the development of dimethylnitrosamine-induced hepatic fibrosis inmice显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Liver Int2009，29，7： | 1 |
| 20 | Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice显示文摘 | Latella G Vetuschi A Sferra R | 2009 | Liver lnt2009，29，7： | 1 |
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