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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Colorectal carcinogenesis:Road maps to cancer显示文摘 | Daniel L Worthley Vicki L Whitehall Kevin J Spring Barbara A Leggett | 2007 | World Journal of Gastroenterology2007，，28： | 2 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 4 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | Pierre Le-Clech Vicki Chen Tony A G F | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 5 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 6 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | PIERRE L C VICKI C TONY A G | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 7 | Stabilization of enzymes in nanoporous materials for biosensor applications显示文摘 | Sofia Sotiropoulou Vicky Vamvakaki Nikos A Chaniotakis | 2005 | Biosensors and Bioelectronics2005，20，： | 1 |
| 8 | Second-Trimester Ultrasound to Detect Fetuses With Down Syndrome显示文摘 | REBECCA SMITH-BINDMAN WYLIE HOSMER VICKIE A FELDSTEIN | 2001 | JAMA2001，285，8： | 1 |
| 9 | Fouling in membrane bioreactors used in wastewater treatment显示文摘 | Pierre Le-Clech Vicki Chen Tony A G Fane | 2006 | J Membr Sci2006，284，12： | 1 |
| 10 | The role of political skill in thestressor-outcome relationship: dfferential predictions for self-and other-reports of political skill 显示文摘 | Meurs J A Vickie C G | 2010 | Journal of VocationalBehavior2010，76，1： | 1 |
| 11 | Nitric oxide inhibits mitochondrial movement in forebrain neurons as- sociated with disruption of mitochondrial membrane potential显示文摘 | Gordon L R Vicki J B Natalia A P | 2006 | Journal of Neurochemistry2006，97，： | 1 |
| 12 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013，，9867： | 1 |
| 13 | Comparison of liquid chromatographic method with direct detection for the analysis of gentamicin显示文摘 | Vicky Manyang a Olga Grishina Erwin Adans | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，45，： | 1 |
| 14 | The use of high sensitiveity c-reactive protein in assessing the risk for coronary heart disease显示文摘 | Vicky A Legrys | 2001 | Clin Lab Sci2001，14，4： | 1 |
| 15 | The development of a naturalistic data collection system to perform critical incident analysis: an investigation of safety and fatigue issues in long-haul trucking显示文摘 | Dingus Thomas A Neale Vicki L Klauer Sheila G | 2006 | Accident Analysis and Prevention2006，38，6： | 1 |
| 16 | Starches in Food显示文摘 | Vickie A Vaclavik Elizabeth W Christian | 2008 | Essentials of Food Science2008，，： | 1 |
| 17 | An overview of the Trilinos project显示文摘 | Heroux Michael A Bartlett Roscoe A Howle Vicki E | 2004 | ACM Transactions on Mathematical Software2004，31，3： | 1 |
| 18 | Fouling in membrane bioreactors used in wasterwater treatment显示文摘 | PIERRE L VICKI C TONY A | 2006 | Journal of Membrane Science2006，284，12： | 1 |
| 19 | Effects of antenatal colonization with Ureaplasma urealyticum on pulmonary disease in the immature baboon显示文摘 | Yoder B A Jacqurline J C Vicki T W | 2003 | Pediatric Research2003，54，： | 1 |
| 20 | Anxiety in children and adolescents with autism spectrum disorders 显示文摘 | MacNeil BM Vicki A Minnes PM | 2009 | Res Autism Spectrum Disorders2009，3，2： | 1 |
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