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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Progastrin Stimulates Colonic Cell Proliferation via CCKBR- and β-Arrestin–Dependent Suppression of BMP2显示文摘 | Guangchun Jin C. Benedikt Westphalen Yoku Hayakawa Daniel L. Worthley Samuel Asfaha Xiangdong Yang Xiaowei Chen Yiling Si Hongshan Wang Yagnesh Tailor Richard A. Friedman Timothy C. Wang | 2013 | Gastroenterology2013，，： | 2 |
| 3 | Mannose-binding lectin and maladies of the bowel and liver显示文摘Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate mo-tifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infec-tious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immuno-logical damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease. | Daniel L Worthley Peter G Bardy David L Gordon Charles G Mullighan | 2006 | World Journal of Gastroenterology2006，12，40： | 2 |
| 4 | Colorectal carcinogenesis:Road maps to cancer显示文摘 | Daniel L Worthley Vicki L Whitehall Kevin J Spring Barbara A Leggett | 2007 | World Journal of Gastroenterology2007，，28： | 2 |
| 5 | Effect of ATP-sensitive potassium channel inhibition on resting coronary vascular responses in humans显示文摘 | Farouque HM Worthley SG Meredith IT | 2002 | Circ Res2002，90，2： | 1 |
| 6 | Serial in vivo MRI documents arterial remodeling in experimental atherosclerosis 显示文摘 | WORTHLEY SG HELFT G FUSTER V | 2000 | Circulation2000，101，6： | 1 |
| 7 | Effect of ATP-sensitive potassium channel inhibition on resting cor- onary vascular responses in humans显示文摘 | Farouque HM Worthley SG Meredith IT | 2002 | Circ Res2002，90，2： | 1 |
| 8 | The role of plaque rupture and thrombosis in coronary artery disease显示文摘 | Zaman AG Helft G Worthley SG | 2000 | Atherosclerosis2000，149，2： | 1 |
| 9 | Mesenchymal Stromal Cells: Potential for Cardiovascular Repair显示文摘 | Psaltis PJ Zannettino ACW Worthley SG | 2008 | STEM CELLS2008，26，： | 1 |
| 10 | A simple percutaneous tracheostomy technique显示文摘 | Griggs WM Worthley LI Gi lligan JE | 1990 | Surg Gynec Obste1990，，170： | 1 |
| 11 | Validation of cardiovascu- lar magnetic resonance assessment of pericardial adipose tissue vol- ume显示文摘 | Nelson A J Worthley M I Psahis P J | 2009 | J Cardiovasc Magn Reson2009，11，： | 1 |
| 12 | The role of plaque rupture and thrombosis in coronary artery disease显示文摘 | Zaman AG Helft G Worthley SG | 2000 | Atherosclerosis2000，149，2： | 1 |
| 13 | The role of plaque rupture and thrombosis in coronary artery disease 显示文摘 | ZAMAN AG HELFT G WORTHLEY SG | 2000 | Atherosclerosis2000，149，： | 1 |
| 14 | Clinical and Angiographic Results With the Next-Generation Resolute Stent System显示文摘 | Ian T. Meredith Stephen Worthley Robert Whitbourn Darren L. Walters Dougal McClean Mark Horrigan Jeffrey J. Popma Donald E. Cutlip Ann DePaoli Manuela Negoita Peter J. Fitzgerald | 2009 | JACC: Cardiovascular Interventions2009，，10： | 1 |
| 15 | Concise review:mesenchymal stromal cells:potential for cardiovascular repair显示文摘 | Psaltis PJ Zannettino AC Worthley SG | | 0，，09： | 1 |
| 16 | A prospective comparison of a percutaneoust racheostomy technique withstandard surgicaltraeheostomy 显示文摘 | Gfiggs WM Myburgn JA Worthley LI | 2003 | Intensive Care Med2003，17，5： | 1 |
| 17 | The role of plaque rupture and thrombosis in coronary artery disease 显示文摘 | Zaman AG Helft G Worthley SG | 2000 | Atherosclerosis2000，149，： | 1 |
| 18 | Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension:the EnligHTN I trial显示文摘 | Worthley SG Tsioufis CP Worthley MI | 2013 | Eur Heart J2013，34，28： | 1 |
| 19 | Non-invasive in vivo magnetic resonance imaging of experimental coronary artery lesions in a porcine model显示文摘 | Worthley SG Helft G Fuster V | 2000 | Circulation2000，101，25： | 1 |
| 20 | Prognos- tic implication of hyperglycemia in myocardial infarctionand primary angioplasty显示文摘 | Worthley M I Shrive F M Anderson T J | 2007 | Am J Med2007，120，643： | 1 |
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