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| 1 | Left atrial appendage occluder implantation for stroke prevention in elderly patients with atrial fibrillation: acute and long-term results显示文摘Atrial fibrillation (AF) is the most common cardiac ar-rhythmia in clinical practice with an increasing incidenceand prevalence. With ageing, the risk of thromboembolicand hemorrhagic events increases dramatically. As it hasbeen reported previously, 3-year survival rate among pa-tients with AF over 75 years of age after stroke is less than50%, and almost 90% of those patients will remain dis-abled. | Karapet V Davtyan Andrey A Kalemberg Arpi H Topchyan Georgiy Y Simonyan Ekaterina V Bazaeva Victoria S Shatahtsyan | 2017 | Journal of Geriatric Cardiology2017，14，9： | 4 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace detection显示文摘Metal-organic frameworks(MOFs)have attracted widespread interest due to their unique and unprecedented advantages in microstructures and properties.Besides,surface-enhanced Raman scattering(SERS)technology has also rapidly developed into a powerful fingerprint spectroscopic technique that can provide rapid,non-invasive,non-destructive,and ultra-sensitive detection,even down to single molecular level.Consequently,a considerable amount of researchers combined MOFs with the SERS technique to further improve the sensing performance and broaden the applications of SERS substrates.Herein,representative synthesis strategies of MOFs to fabricate SERS-active substrates are summarized and their applications in ultra-sensitive biomedical trace detection are also reviewed.Besides,relative barriers,advantages,disadvantages,future trends,and prospects are particularly discussed to give guidance to relevant researchers. | Yuna Zhang Cuili Xue Yuli Xu Shengsheng Cui Alexander A.Ganeev Kistenev Yury V Anna Gubal Victoria Chuchina Han Jin Daxiang Cui | 2023 | Nano Research2023，16，2： | 2 |
| 4 | The leisure experience 显示文摘 | Victoria A A Rafael S Esperanza V | 2008 | The Journal of Socio-Economics2008，37，1： | 1 |
| 5 | Positive psychology group intervention for breast cancer patients: a ran- domised trial显示文摘 | Victoria Cerezo M Ortiz-Tallo M Cardenal V | 2014 | Psychol Rep2014，115，1： | 1 |
| 6 | Nanocrystalline electrodeposited Ni microstrueture and tensile properties 显示文摘 | DALLA T F SWYGENHOVEN H V VICTORIA M | 2002 | Acta Materialia2002，50，： | 1 |
| 7 | A simple and rapid HPLC- MS method for the simultaneous determination of epinephrine, norepinephrine,dopamine and 5-hydroxytryptamine Application to the seeretion of bovine ehromaffin cell cultures显示文摘 | Victoria C Esther S Eugenio V | 2007 | Journal of Chromatography B2007，847，2： | 1 |
| 8 | Elimination of polycyclic aromatic hydrocarbons by bleaching of olive pomace oil显示文摘 | MANUEL L C ISABEL V A VICTORIA R M | 2003 | Eur J Lipid Sci Technol2003，105，1： | 1 |
| 9 | A multivariate adaptive regression splines cutting plane approach for solving a two-stage stochastic programming fleet assignment model显示文摘 | PILLA V L ROSENBERGER J M VICTORIA CHEN | 2012 | European Journal of Operational Research2012，216，： | 1 |
| 10 | Failure to up-regulate VEGF165b in maternal plasma is a rsttrimester predictive marker for pre-eclamp-sia显示文摘 | Victoria L Bill S Julia V | 2009 | Clinical Science2009，116，38： | 1 |
| 11 | Mechanical dispersion of Y2O3 nanoparticles in steel EUROFER 97:process and optimisation显示文摘 | de CASTRO V LEGUEY T MONGE M A MU-OZ A PAREJA R AMADOR D R TORRALBA J M VICTORIA M | 2003 | Journal of Nuclear Materials2003，322，23： | 1 |
| 12 | Multiframe maximum likelihood tag estimation for RFID anti-collision protocols显示文摘 | Javier V A Victoria B D Esteban E L | 2011 | IEEE Transactions on Industrial Informatics2011，7，3： | 1 |
| 13 | Purification of zinc sulfate solutions from cobalt and nickel through activated cementation显示文摘 | Boyan S B Victoria V K Nikolai K K | 2004 | Hydrometallurgy2004，73，2： | 1 |
| 14 | Circadian sensitivity to the chemotherapeutic agent cyclophos pha mide depends on the func tional status of the CLOCK/MAL1 trans activation complex显示文摘 | Victoria Y Gorbacheva Roman V | 2005 | The National Academy of Sciences of the USA March 12005，102，9： | 1 |
| 15 | Simulation of the effects of land use changes in soil carbon dynamics in the Piracicaba river basin, Sao Paulo State, Brazil 显示文摘 | Silveria A M Victoria R L Baliester M V | 2000 | Brasileira2000，35，2： | 1 |
| 16 | Daubechies wavelet beam and plate finite elements 显示文摘 | LILLIAM A D MARIA T M VICTORIA V | 2009 | Finite Elements in Analysis and Design2009，45，10： | 1 |
| 17 | Effects of environmental factors on woodformation in larch stems显示文摘 | Galina F A Victoria V S | 1997 | Trees1997，11，8： | 1 |
| 18 | Rapid autom ated determ ination of adenosione deam inase and lysozyme for differentiating tuberculous and nontuberculous pleural effusion显示文摘 | Victoria V Jose Antonio NG Criseina GB | 1996 | Clin Chem1996，2，42： | 1 |
| 19 | Characterisation of the oral adjuvant effect of lemnan,a pectic polysaccharide of Lemna minor L显示文摘 | Sergey V Popov Victoria V Golovchenko Raisa G Ovodova | | Vaccine0，24，26： | 1 |
| 20 | Glottal source biometricalsignature for voice pathology detection显示文摘 | PEDRO G V ROBERTO F B VICTORIA R B VICTOR N L AGUSTIN A M LUIS M M F RAFAEL M O JUAN I G L | 2009 | Speech Communication2009，51，9： | 1 |
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