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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Determination of multiclass pesticides in food commodities by pressurized liquid extraction using GC-MS/MS and LC-MS/MS 显示文摘 | Frenich A G Salvador I M Vidal J L M Lopez T L | 2005 | Analytical and Bioanalytical Chemistry2005，33，78： | 1 |
| 3 | Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry显示文摘 | VIDAL J L M FRENICH A G AGUILERA-LUIZ M M | 2010 | Analytical and Bioanalytical Chemistry2010，397，7： | 1 |
| 4 | Expressionand localization of estrogen receptor-beta in murine andhuman bone显示文摘 | Vidal 0 Kindblom L G Ohlesson C | 1999 | Bone Miner Res1999，14，： | 1 |
| 5 | Licofelone,a balanced inhibitor of cyclooxygenase and 5-lipoxygenase,reduces inflammation in a rabbit model of atherosclerosis显示文摘 | Gómez-Hernández A Sánchez-Galán E | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 6 | Depth-dependent structure of the Landers fault zone from trapped waves generated byaftershocks显示文摘 | Li Y G Vidale J E Aki K | 2000 | Journal of Geophysical Research2000，105，3： | 1 |
| 7 | Conjugated Polyrotaxanes in Corporating Mono-ordivalent Copper Complexes 显示文摘 | VIDAL P L DIVISIA-BLOHORN B BIDAN G | 1999 | Inorg Chem1999，38，： | 1 |
| 8 | Influence of the content in fats and proteins on the anaerobic biodegradability of dairy wastewaters显示文摘 | Vidal G Carvlho A Mndez R | 2000 | Bioresource Technology2000，74，： | 1 |
| 9 | Determination of total and pancreatic a-amylase in human serum with 2-chloro-4-nitropyenl-α-D-maltotrisoide as substrate 显示文摘 | Gella F Gubern G Vidal R | 1997 | Clin Chim Acta1997，259，： | 1 |
| 10 | Develop- ment and field test of an on-line computerized instrumenta- tion system for air velocity, temperature and differential pressure measurements in poultry houses 显示文摘 | Blanes Vidal V Guijarro E Nadimi A G | 2010 | Spanish Journal of Agricultural Research2010，8，3： | 1 |
| 11 | Thehumna Ucoupuling Protein-3 gene:genesurteutre, chromosomaUoealization,and genetie basis of short nadlongofmr tnarseriPts 显示文摘 | Solnaes G Vidal PA Gurjie D | 1997 | J Biol Chem1997，272，25： | 1 |
| 12 | Behaviour of molecular weight distribution for the liquid fraction of pig slurry treated by anaerobic digestion 显示文摘 | Rodirguez D C Belmonte M Penuela G Campos J L Vidal G | 2011 | Environmental Technology2011，33，4： | 1 |
| 13 | Dynamic template Track- ing and recognition显示文摘 | Chaudhry R Hager G Vidal R | 2013 | International Journal Of Computer Vision2013，105，1： | 1 |
| 14 | Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ER beta(-/-) mice显示文摘 | Windahl SH Vidal O Andersson G | 1999 | J Clin Invest1999，104，7： | 1 |
| 15 | Stability of plant sterols in ingredients used in functional food显示文摘 | González-Larena M Garcila-Llatas G Vidal MC | 2011 | Journal of Agricultural and Food Chemistry2011，59，8： | 1 |
| 16 | Pilot-plant technical assessment of wet flue gas desulfurization using limestone 显示文摘 | ORTIZ F 3 G VIDAL F OLLERO P | 2006 | Industrial & Engineering Chemistry Research2006，45，： | 1 |
| 17 | High level of expression of a protective antigen of schistosomes in Saccharomyces cerevisiae显示文摘 | Loison G Vidal A Findeli A | | 0，，： | 1 |
| 18 | Towards an improved and moreflexible representation of water stress in coupled photosynthesis-stomatal conductance models显示文摘 | EGA G VERHOEF A VIDALE P L | 2011 | Agric Forest Meteorol2011，151，： | 1 |
| 19 | High-throughput determination of pesticide residuesin food commodities by use of ultra-performance liquid chromatography-tandem mass spectrometry显示文摘 | FRENICH A G VIDAL J L M MONTORO E A GONZALEZ R | 2008 | Anal Bioanal Chem2008，390，3： | 1 |
| 20 | Application of gas chro- matography - tripl quadrupole mass spectrometry in the quantifica- tion - confirmation of pesticides and Polychlorinated biphenyls in eggs at trace level显示文摘 | BOLANOS P P FRENICH A G VIDAL J L | 2007 | J Chromatogr A2007，1167，1： | 1 |
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