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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus显示文摘 | Vincent I E Carrasco C P Herrmann B | 2003 | J Virol2003，77，13： | 1 |
| 3 | Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia显示文摘 | Vincent P C Clark S J | 1999 | Cancer Res1999，59，15： | 1 |
| 4 | Transcriptio- nal organization of the avian adenovirus CELO 显示文摘 | Vincent P Arnauld C Picault J | 1998 | J Virol1998，72，11： | 1 |
| 5 | An epigenetic mutation responsi- ble for natural variation in floral symmetry 显示文摘 | Cubas P Vincent C Coen E | 1999 | Nature1999，401，： | 1 |
| 6 | Suppression of Multiple Narrowband Interference in a Spread- spectrum Communication System显示文摘 | Catharina C Vincent P H Andrew L | 2000 | IEEE Journal on Selected Areas in Communication2000，18，： | 1 |
| 7 | The perceived usefulness of blog postings : An extension of the expectancy - disconfirmation paradigm 显示文摘 | Anita Zehrer John C Crotts Vincent P Magnini | 2010 | Tourism Management2010，31，6： | 1 |
| 8 | Capacity loss of lithium manganese oxide spinel in LiPF6/ethylene carbonate-dimethyl carbonate electrolytes显示文摘 | Huang H Vincent C A Bruce P G | 1999 | J Electrochem Soc1999，146，2： | 1 |
| 9 | The significance of needle placement site in acupuncture 显示文摘 | Vincent C A Richardson P H Black J J et aI | 1989 | J PsychosomRes1989，33，4： | 1 |
| 10 | Class-Based n-gram Models of Natural Language显示文摘 | PETER F B VINCENT J D P PETER V D JENIFER C L ROBERT L M | 1992 | Computational Linguistics1992，，： | 1 |
| 11 | Correlating capacity loss of stoichiometric and nonstoichiometric lithium manganesse oxide spinel electrodes with their structural integrity 显示文摘 | HUANG Hai-tao VINCENT C A BRUCE P G | 1999 | J Electrochem Soc1999，146，10： | 1 |
| 12 | Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia 显示文摘 | Melki J R Vincent P C Clark S J | 1999 | Cancer Res1999，59，15： | 1 |
| 13 | Clinical and microbiologic characteristics of children treated at the Fort De France University Hospital after the 2010 Haiti earthquake显示文摘 | Arqus I Vincent M Olive C Cabi6 A Canivet I Hochedez P | 2013 | Pediatr Infect Dis J2013，32，5： | 1 |
| 14 | Stigma, social inequality, and HIV risk disclosure among Dominican male sex workers 显示文摘 | Mark P Daniel C Vincent GR | 2008 | Social Science and Medicine2008，67，： | 1 |
| 15 | Dose Planning Study of Target Volume Coverage with Intensity - Modulated Radio- therapy for Nasopharyngeal Carcinoma: Penang General Hospital Ex- perience显示文摘 | Vincent P C E Boon Seang T Ai Lian T | 2013 | Asian Pacific Journal of Cancer Prevention Apjcp2013，14，4： | 1 |
| 16 | Measuring suspended sediment concentrations using acoustic backscatter devices显示文摘 | Vincent C E Hardcnstle P J | 1991 | Marine Geology1991，98，： | 1 |
| 17 | A novel short peptide is a specific inhibitor of the Human Immunodeficiency Virus Type 1 Integrase显示文摘 | Vaea R S Anne C Vincent P | 2002 | J Mol Biol2002，318，： | 1 |
| 18 | A paleomagnetic study of Mesozoic sediments from the Junggar and Turfan basins, northwestern China显示文摘 | Cogne J P Chen Y Vincent C | 1995 | Earth and Planetary Science Letters1995，133，： | 1 |
| 19 | Self-optimizing traffic signal control using microprocessors - the TRRL ' Mova' strategy for isolated intersections显示文摘 | Vincent R A Young C P | 1986 | Traffic Engineering & Control1986，27，78： | 1 |
| 20 | Diagnosis and treatment of patients with trigeminal neuralgia显示文摘 | SHAHROKH C B FARIBA F VINCENT J P | 2004 | J Am Dent Assoc2004，135，： | 1 |
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