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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | New reconfigurable architectures for implementing FIR filters with low complexity显示文摘 | Mahesh R Vinod A P | | 0，，02： | 1 |
| 3 | A comparison of ICRU point doses and volumetric doses of organs at risk (OARs) in brachytherapy for cervical cancer 显示文摘 | VINOD S K CALDWELL K LAU A | 2011 | J Med Imaging Radiat Oncol2011，55，3： | 1 |
| 4 | Crossover from photodarkening to photobleaching in a-GexSel00_x thin films 显示文摘 | KUMAR R BARIK A VINOD E | 2013 | Opt Lett2013，38，： | 1 |
| 5 | EECbased classification n of fast and slow hand movements using wavelet-CSP algorithm 显示文摘 | Robinson N Vinod A /kng K | 2013 | Biomedical Engineering2013，60，8： | 1 |
| 6 | Improved superconducting properties by La addition in(Bi,Pb)-2212 bluk superconductor显示文摘 | Biju A Vinod K Aloysius R P | 2007 | Journal of Alloys Compounds2007，431，： | 1 |
| 7 | Reconfigurable low area complexity filter bank architecture based on frequency response masking for nonuniform channelization in software radio receivers 显示文摘 | Mahesh R Vinod A P | 2011 | IEEE Transactions on Aerospace and Electronic Systems2011，47，2： | 1 |
| 8 | Design of multistandard channelization accelerators for software defined radio handsets 显示文摘 | Navin M Vinod A P Christophe M | 2011 | IEEE Transactions on Signal Processing2011，59，10： | 1 |
| 9 | A Multi-Resolution Fast Filter Bank for Spectrum Sensing in Military Radio Receivers 显示文摘 | Smitha K G Vinod A P | 2012 | Very Large Scale Integration ( VLSI ) Systems IEEE Transactions on2012，20，7： | 1 |
| 10 | Potential of Laceyella saccharistrain B42 crude xylanase in biobleaching of kraft pulp显示文摘 | Vikram S Vinod C P Sanjeev A | 2013 | Afri-can Journal of Biotechnology2013，12，6： | 1 |
| 11 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 12 | Viscoplastic Analysis of an Experimental Cylindrical Thrust Chamber Liner显示文摘 | Vinod K A Steven M A | 1992 | AIAA Journal1992，30，3： | 1 |
| 13 | Coexistence of fast photodarkening and slow photobleaching in GelgAs21Se60 thin films 显示文摘 | KHAN P BAR/K A R VINOD E M | 2012 | Opt Express2012，20，12： | 1 |
| 14 | A new common subexpression elimination algorithm for realizing low complexity higher order digital filters 显示文摘 | Mahesh R Vinod A P | 2008 | IEEE Transactions on Computer Aided Design of Integrated Circuits and Systems2008，27，2： | 1 |
| 15 | Triaxial compression of clay reinforced with sand coir fiber core 显示文摘 | Vinod P Bhaskar A Leshhmi C S | 2007 | Geotechnical Testing Journal2007，30，4： | 1 |
| 16 | Catalytic and electrocatalytic properties of intrazeolitically prepared iron phthalocyanine 显示文摘 | Vinod M P Das Kr T Chandwadkar J A | 1999 | Materials Chemistry and Physics1999，58，： | 1 |
| 17 | AgNOa--a potential regulator of ethylene activity and plant growth modulator显示文摘 | Vinod K Giridhar P Gokare A R | 2009 | Elec- tronic Journal of Biotechnology2009，，12： | 1 |
| 18 | Recent coal fire and land use status of Jharia Coalfield, India from satellite data显示文摘 | MARTHA T R C-UHA A VINOD K K | 2010 | International Journal of Remote Sensing2010，31，12： | 1 |
| 19 | Enhancing active learning in mi- crobiology through case based learning: experiences from an Indian medi- cal school 显示文摘 | Ciraj A M Vinod P Ramnarayan K | 2010 | Indian Journal of Pathology and Microbiology2010，53，4： | 1 |
| 20 | Fast two-stage spectrum de- tector for cognitive radios in uncertain noise channels显示文摘 | NAIR P R VINOD A P SMITHA K G | 2012 | IET Com- munications2012，6，11： | 1 |
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