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| 1 | Analysis of aggressiveness factors in hepatocellular carcinoma patients undergoing transarterial chemoembolization显示文摘AIM To investigate novel predictors of survival in hepatocellular carcinoma(HCC) patients following transarterial chemoembolization(TACE).METHODS One hundred sixty seven patients with un-resectable HCC were retrospectively analyzed to identify factors that might contribute to their HCC biology and aggressiveness. We correlated routine laboratory results(total bilirubin, AST, ALKP, GGTP, albumin etc.) to maximum tumor diameter, number of tumor nodules, portal vein thrombosis and blood alpha-fetoprotein levels. These 4 parameters were previously combined to form an aggressiveness index(AgI). We used The Wilcoxon ranksum(Mann-Whitney), to test the correlation between the AgI categories and liver function parameters. The Cox proportional hazards model was applied to evaluate the categories of AgI associated with overall survival. RESULTS The AgI was strongly correlated with survival in this novel patient population. Three year survival probability for AgI > or < 4 was 42.4% vs 61.8%; P < 0.0863 respectively. Several factors independently correlated with AgI using univariate multiple logistic regression of AgI with 8 laboratory parameters. Lower albumin levels had an OR of 2.56(95%CI: 1.120-5.863 P < 0.026), elevated Alkaline phosphatase and gamma glutamyl transpeptidase(GGTP) had ORs of 1.01(95%CI: 1.003-1.026, P < 0.017) and 0.99(95%CI: 0.99-1.00, P < 0.053) respectively. In a Cox proportional hazard model combining mortality for AgI score and liver function parameters, only GGTP levels and the AgI were independently associated with survival. An AgI > 4 had HR for mortality of 2.18(95%CI: 1.108-4.310, P < 0.024). GGTP's single unit change had a HR for mortality of 1.003(95%CI: 1.001-1.006, P < 0.016). These were considered in the final multivariate model with the total cohort. An AgI > 4 had a HR for mortality of 2.26(95%CI: 1.184-4.327, P < 0.016). GGTP had a HR of 1.003(95%CI: 1.001-1.004, P < 0.001).CONCLUSION Our study validates the AgI in a new population with un-resectable HCC patients undergoing TACE. The analysis establishes a correlation between GGTP and the AgI. | Yossi Ventura Brian I Carr Issac Kori Vito Guerra Oren Shibolet | 2018 | World Journal of Gastroenterology2018，24，15： | 1 |
| 2 | Differences in mi- croparticle release in patients with acute coronary syndrome and Stable angina 显示文摘 | Biasucci LM Porto I Di Vito L | 2012 | Circ J2012，76，9： | 1 |
| 3 | Participation of presenilin 2 in apoptosis:enhanced basal activity conferred by an Alzheimer mutation显示文摘 | Wolozin B I wasaki K Vito P | | 0，，： | 1 |
| 4 | Differences in mi- croparticle release in patients with acute coronary syn- drome and stable angina显示文摘 | Biasucci LM Porto I Di Vito L | 2012 | Circ J2012，76，9： | 1 |
| 5 | A cost allocation problem in urban solid wastes col- lection and disposal 显示文摘 | Vito F Anna I | 2004 | Mathematical Methods of Operations Research2004，29，3： | 1 |
| 6 | Centrality Measures in Spatial Networks of Urban Streets显示文摘 | CRUCITI'I PAOLO VITO LATORA SERGIO POR- TA | 2006 | Physical Review E2006，73，： | 1 |
| 7 | Anomalous atonuc volume of a Pu显示文摘 | KOLLAR J VITOS I Skriver H L | 1997 | Phys Rev B1997，55，15： | 1 |
| 8 | Transcription of the mitochondrial citrate carrier gene: Role of SREBP-1, upregula- tion by insulin and downregulation by PUFA显示文摘 | Vittoria I Vito I Francesco De S | 2007 | Biochem Bioph Res Co2007，356，： | 1 |
| 9 | Slurry sampling in serum blood for mercury determination by CV-AFS显示文摘 | Aranda P R Gil R A Moyano S De Vito I Martinez L D | 2009 | Journal of Hazardous Materials2009，161，23： | 1 |
| 10 | Differences in microparticle release in patients with acute coronary syndrome and stable angina显示文摘 | Biasucci LM Porto I Di Vito L | 2012 | Circ J2012，76，9： | 1 |
| 11 | Differences in microparticlerelease in patients with acute coronary syndrome and stableangina显示文摘 | Biasucci LM Porto I Di Vito L | 2012 | Circ J2012，76，9： | 1 |
| 12 | Microparticles in health and disease: small mediators, large role? 显示文摘 | Porto I De Mafia GL Di Vito L | 2011 | Curr Vasc Pharmacol2011，9，4： | 1 |
| 13 | Anisotropic lattice distortions in random alloys from first-pinciples theory显示文摘 | VITOS L ABRIKOSOV I A JOHANSSON B | 2001 | Physical Review Letters2001，87，15： | 1 |
| 14 | Intratympanic methylprednisolone in refracto'y sudden hearing loss: a 27-patient case series with univari- ate and multivariate analysis显示文摘 | Dallan I De Vito A Fattori B | 2010 | Otol Neurotol2010，31，1： | 1 |
| 15 | Differences in microparticle release in patients with acute coronary syndrome and Stable angina显示文摘 | Biasucci LM Porto I Di Vito L | 2012 | Circ J2012，76，9： | 1 |
| 16 | Differences in microparti- cle release in patients with acute coronary syndrome and stable an- gina显示文摘 | Biasucci LM Porto I Di Vito L | 2012 | Circ J2012，76，9： | 1 |
| 17 | Innovation in industrial districts:An agent-based simulation model显示文摘 | Vito A Nunzia C Giannoccaro I | 2006 | International Journal of Product Economics2006，10，4： | 1 |
| 18 | Performance Model Analysis of Armenian Premier League Soccer Players Using Global Positioning System Technology and Comparison between European Championship显示文摘The aim of this research was to analyze the PPM of Armenian Premier League using 25 GPS 10 Hz(K-Sport,Montelabbate,Italy),in order to compare data from literature from major European championship.In total 25 matches were analyzed from one team militant in Armenian Premier League(10 wins,10 loses and 5 draws),33 different players(age 24.3±4.2,height 1.76±4.2 and weight 74±3.5)and in total 270 performances(10.8 for matches).Matches were divided in First Half(T1),Second Half(T2),Second Half Substitution(T2 Sub),Full Match,Full Match Substitution(Full Match Sub)and Total Match(Total)that include all the players detected during a games.Furthermore,all matches were divided even by quarters 0-15,15-30,30-45,45-60,60-75 and 75-90,only players that played all match were included in this analyses,in order to check the performance decreasing during the time.All data were added in an Excel Spreadsheet in order to build a database,to organize and better analyze data,cataloging events for data,results,and role of players.Average data from Armenian Premier League in comparison with literature data from European and Italian Championship show that in every parameter,the Armenian Premier League is under the average.This is obviously related to the non-high level of the Armenian football that is in fact placed at the 106°place of the FIFA ranking(update 7 June 2019).Physical data represent an indicator of performance but also of the qualitative level of the league and of individual players.For this reason,the use of the match analysis can be decisive to verify the PPM,in order to better evaluate the championships,teams,and players,in order to build an easier search and discovery of talents. | Riccardo Izzo Ciro Hosseini Varde’i Vito Azzone | 2019 | Journal of Sports Science2019，7，2： | 0 |
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