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| 1 | Long-term albumin infusion improves survival in patients with cirrhosis and ascites: An unblinded randomized trial显示文摘瞄准:在幸存上调查长期的白朊管理的效果,腹水的复发和另外的复杂并发症的发作。方法:为第一发作的腹水招收的 100 个连续病人被使随机化加人的白朊收到利尿剂第一年和 25 g 里的 25 g/wk 每二 wk 此后(组 1 ) 或利尿剂独自一个(组 2 ) 。没有肝移植,主要端点是幸存。第二等的端点是腹水的复发和另外的复杂并发症的出现。结果:中部的后续是 84 (2-120 ) 瞬间。对待白朊的病人有显著地更大的累积幸存率(Breslow test=7.05, P=0.0078 ) 并且腹水复发的更低的概率(51% 对 94% , P<0.0001 ) 。长期的白朊注入导致了 16 瞬间的幸存的吝啬的增加。结论:在第一发作的腹水以后的长期的白朊管理显著地改进病人的幸存并且减少腹水复发的风险。 | Roberto Giulio Romanelli Giorgio La Villa Giuseppe Barletta Francesco Vizzutti Fabio Lanini Umberto Arena Vieri Boddi Roberto Tarquini Pietro Pantaleo Paolo Gentilini Giacomo Laffi | 2006 | World Journal of Gastroenterology2006，12，9： | 22 |
| 2 | Fibrosis and Cirrhosis Reversibility: Clinical Features and Implications显示文摘 | Massimo Pinzani Francesco Vizzutti | 2008 | Clinics in Liver Disease2008，，4： | 2 |
| 3 | Small diameter H-graft porta-caval shunt performed at different stages of liver disease显示文摘BACKGROUND: Partial porto-systemic shunts have been popularized because of reported low rate of mortality and morbidity (especially encephalopathy, liver failure and oc- clusion). To further investigate these assumptions, we ret- rospectively reviewed the results of partial porta-caval shunts performed at different stages of liver disease. METHODS: Twenty-nine cirrhotic patients underwent a partial porta-caval shunt with a ringed polytetrafluoroethy- lene interposition prosthesis of 8-mm ( 20 patients) or 10- mm (9 patients) in diameter. Pre- and post-shunt porta- caval pressure was measured in all patients. Twelve patients (41.4%) belonged to Child A, 11 Child B (37.9%), and 6 Child C (20.7%). Eleven patients (37.9%) suffered from hepatic encephalopathy preoperatively. Twelve patients (41%) were operated on in emergency/urgency. RESULTS: Porta-caval pressure gradient, reduced signifi- cantly using either 8- or 10-mm prosthesis. The overall ear- ly mortality and morbidity were 13. 8% and 48% respec- tively. The early mortality and morbidity were different be- tween patients of Child A and B when compared to those of Child C (0 vs 66.6% and 34.8% vs 66.6% respectively). No patient re-bled early from varices. The overall late mor- tality and morbidity were 40% and 64% respectively. Shunt thrombosis and stenosis took place in 16% and 8% of the two groups of patients respectively; variceal re-bleeding oc- curred in 4 patients (16%). Encephalopathy occurred post- operatively in 5 patients (20%), acute in 3 patients (12%), and chronic in 2 (8%). The actuarial survival rate at 3 and 5 years was 92% and 75% for patients of Child A, 70% and 60% for patients of Child B, and 0% for patients of Child C. CONCLUSIONS: Our results indicate that partial porta-ca- val shunt with a small diameter interposition H-graft is an effective procedure for the treatment of variceal bleeding, as well as for the prevention of re-bleeding in patients of Child A and those of Child B, as an elective or emergency/ urgency procedure, with a low rate of complications and encephalopathy. This technique could be used safely in pa- tients with good liver function but they should be moni- tored closely because of the risk of shunt occlusion. | Giacomo Batignani Francesco Vizzutti Luigi Rega Michele Zuckermann Geri Fratini Massimo Pinzani Francesco Tonelli | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 1 |
| 4 | Anti-VEFG receptor-2 monoclonal prevents portal-systemic collateral vessel formation in portal hypertensive mice显示文摘 | FERNANDEZ M VIZZUTTI F GACIA-PAGAN JC | 2004 | Gastroenterology2004，126，3： | 1 |
| 5 | Liver stiffness measure ment predicts severe portaJ hypertension in patJents with HCV - related cirrhosis显示文摘 | Vizzutti F Arena U Romanelli RG | 2007 | Hepatology2007，45，5： | 1 |
| 6 | Acute viral hepatitis increases liver stiffness values measured by transient elastography显示文摘 | Arena U Vizzutti F Corti G | 2008 | Hepatology2008，47，2： | 1 |
| 7 | Elastography for the noninvasive assessment of liver disease:limitations and future developments 显示文摘 | Vizzutti F Arena U Marra F | 2009 | Gut2009，58，2： | 1 |
| 8 | Anti-VEGF receptor-2 monoclonal antibody prevents portal- systemic collateral vessel formation in portal hypertensive mice 显示文摘 | FERNANDEZ M VIZZUTTI F GARCIA- PAGAN J C | 2004 | Gastroenterol2004，126，： | 1 |
| 9 | Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice 显示文摘 | Fernandez M Vizzutti F Garcia-Pagan JC | 2004 | Gastroenterology2004，126，3： | 1 |
| 10 | Transient elastography for the assessment of liver fibrosis in patients with chronic viral hepatitis: the missing tool?显示文摘 | Stasi C Arena U Vizzutti F | 2009 | Dig Liver Dis2009，41，12： | 1 |
| 11 | Acute viral hepatitis in-creasesliver stiffness valuesmeasured by transient elastogra-phy显示文摘 | Arena U Vizzutti F Corti G | 2008 | Hepatology2008，47，2： | 1 |
| 12 | Update on ascite and hepatorenal syndrome显示文摘 | Gentilini P Vizzutti F Gentilini A | 2002 | Dig Liver Dis2002，34，8： | 1 |
| 13 | Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice 显示文摘 | Fernandez M Vizzutti F Garcia-Pagan JC | 2004 | Gastroenterology2004，126，3： | 1 |
| 14 | Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis显示文摘 | Vizzutti F Arena U Romanelli RG | 2007 | Hepatology2007，45，5： | 1 |
| 15 | Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice显示文摘 | Fernandez M Vizzutti F Garcia-Pagan JC | | 0，，： | 1 |
| 16 | Silybin,a component of sylimarin,exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells显示文摘 | Trappoliere M Caligiuri A Schmid M Bertolani C Failli P Vizzutti F Novo E di Manzano C Marra F Loguereio C Pinzani M | | 0，，： | 1 |
| 17 | Non-invasive assessment of fibrosis in non-alcoholic fatty liver disease显示文摘 | Vizzutti F Arena U Nobili V | 2009 | Ann Hepatol2009，8，8： | 1 |
| 18 | Acute viral hepatitis increases liver stiffness values measured by transient elastography显示文摘 | Arena U Vizzutti F Corti G | 2008 | Hcpa tology2008，47，2： | 1 |
| 19 | Liver stiffness measurement predicts severe portal hypertension in pa- tients with HCV-related cirrhosis显示文摘 | Vizzutti F Arena U Romanelli RG | 2007 | Hepatology2007，45，5： | 1 |
| 20 | Non invasive diagnosis of portal hypertension in cirrhotic patients显示文摘 | Vizzutti F Arena U Rega L | 2005 | Gastroenterologie Clinique et Biologique2005，29，10： | 1 |
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