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| 1 | Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7显示文摘AIM To present the incidence of heterotopic ossification after the use of recombinant human bone morphogenetic protein-7(rhB MP-7) for the treatment of nonunions.METHODS Bone morphogenetic proteins(BMPs) promote bone formation by auto-induction. Recombinant human BMP-7 in combination with bone grafts was used in 84 patients for the treatment of long bone nonunions. All patients were evaluated radiographicaly for the development of heterotopic ossification during the standard assessment for the nonunion healing. In all patients(80.9%) with radiographic signs of heterotopic ossification, a CT scan was performed. Nonunion site palpation and ROM evaluation of the adjacent jointswere also carried out. Factors related to the patient(age, gender), the nonunion(location, size, chronicity, number of previous procedures, infection, surrounding tissues condition) and the surgical procedure(graft and fixation type, amount of rhB MP-7) were correlated with the development of heterotopic ossification and statistical analysis with Pearsons χ~2 test was performed.RESULTS Eighty point nine percent of the nonunions treated with rh BMP-7, healed with no need for further procedures. Heterotopic bone formation occurred in 15 of 84 patients(17.8%) and it was apparent in the routine radiologi-cal evaluation of the nonunion site, in a mean time of 5.5 mo after the rh BMP-7 application(range 3-12). The heterotopic ossification was located at the femur in 8 cases, at the tibia in 6, and at the humerus in οne patient. In 4 patients a palpable mass was present and only in one patient, with a para-articular knee nonunion treated with rhB MP-7, the size of heterotopic ossification affected the knee range of motion. All the patients with heterotopic ossification were male. Statistical analysis proved that patient's gender was the only important factor for the development of heterotopic ossification(P = 0.007). CONCLUSION Heterotopic ossification after the use of rh BMP-7 in nonunions was common but it did not compromise the final clinical outcome in most cases, and affected only male patients. | Marianthi Papanagiotou Zoe H Dailiana Theophilos Karachalios Sokratis Varitimidis Michael Hantes Georgios Dimakopoulos Marianna Vlychou Konstantinos N Malizos | 2017 | World Journal of Orthopedics2017，8，1： | 3 |
| 2 | Imaging modalities for renal artery stenosis in suspected renovascular hyperten- sion: prospective intraindividual comparison of color Doppler US, CT angiography, GD-enhanced MR angiogra- phy, and digital substraction angiography 显示文摘 | Rountas C Vlychou M Vassiou K | 2007 | Ren Fail2007，29，3： | 1 |
| 3 | Primary lymphomas of bone显示文摘 | Kitsoulis P Vlychou M | 2006 | Anticancer Res2006，26，1： | 1 |
| 4 | Imaging modalities for renal artery stenosis in suspected renovascular hypertension:prospective intraidividual comparison of color Doppler US,CT angiography显示文摘 | Rountas C Vlychou M VassiouK | 2007 | Ren Fail2007，29，3： | 1 |
| 5 | Low-grade osteosarcoma of the ethmoid sinus显示文摘 | Vlychou M Ostlere S J Kerr R Athanasou N A | 2007 | Skeletal Radiol2007，36，5： | 1 |
| 6 | Characterization of breast lesions with CE-MR multimodal morphological and kinetic analysis: Comparison with conventional mammography and high-resolution ultrasound显示文摘 | Katherine Vassiou Theodorab Kanavou Mariann Vlychou Antigoni Poultsidi Evagelos Athanasiou Dimitrios L. Arvanitis Ioannis V. Fezoulidis | 2008 | European Journal of Radiology2008，，1： | 1 |
| 7 | The role of 3D- computed tomography angiography(3D-CTA) in investiga- tion of spontaneous subarachnoid haemorrhage:comparison with digital subtraction angiography (DSA) and surgical findings 显示文摘 | Kokkinis C Vlychou M Zavras GM et td | 2008 | Br J Neurosurg2008，22，1： | 1 |
| 8 | Imaging modalities forrenal artery stenosis in suspected renovascular hypertension:pro-spective intraindividual comparison of color Doppler US, CT angi-ography, GD enhanced MR angiography, and digital subtractionangiography显示文摘 | Rountas C Vlychou M Vassiou K | 2007 | Ren Fail2007，29，3： | 1 |
| 9 | Symptomatic partial rotator cuff tears: diagnostic performance of ultrasound and magnetic resonance imaging with surgical correlation显示文摘 | Vlychou M Dailiana Z Fotiadou A | 2000 | Acta Radiol2000，50，1： | 1 |
| 10 | Characterization of breastlesions with CE-MR multimodal morphological and kinetic analysis:comparison with conventional mammography and high-resolution ul-trasound显示文摘 | Vassiou K Kanavou T Vlychou M | 2009 | Eur J Radiol2009，70，1： | 1 |
| 11 | Imaging modalities forrenal artery stenosis in suspected renovascular hypertension:prospective intraindividual comparison of color Doppler US,CTangiography,GD-enhanced MR angiography,and digital subst-raction angiography显示文摘 | Rountas C Vlychou M Vassiou K | 2007 | Ren Fail2007，29，3： | 1 |
| 12 | The role of 3D- computed tomography angiography ( 3D-CTA ) in investigation of spontaneous subarachnoid haemorrhage : comparison with dig- ital subtraction angiography (DSA) and surgical findings 显示文摘 | Kokkinis C Vlychou M Zavras GM | 2008 | Br J Neurosurg2008，22，1： | 1 |
| 13 | The role of 3D-computed tomography angiography (3D-CTA) in investigation of spontaneous subarachnoid haemorrhage: comparison with digital subtraction angiog- rapby (DSA) and surgical findings 显示文摘 | Kokkinis C Vlychou M Zavras G M | 2008 | Br J Neurosurg2008，22，1： | 1 |
| 14 | Characterization of breast lesions with CE-MR multimodal morphological andkinetic analysis:Comparison with conventional mammogra- phy and high-resolution ultrasound显示文摘 | Vassiou K Kanavou T Vlychou M | 2009 | Eur J Radiol2009，70，1： | 1 |
| 15 | Autologous ( non-vas- cularised) fibular grafting with recombinant bone morphogenetic pro- tein-7 for the treatment of femoral head osteouecrosis : preliminary re- port显示文摘 | Papanagiotou M Malizos KN Vlychou M | 2014 | Bone Joint J2014，96，1： | 1 |
| 16 | Characterization of breast lesions with CE-MR multimodal morphological and kinetic analysis: comparison with conventional mammography and high- resolution ultrasound显示文摘 | Vassiou K Kanavou T Vlychou M | 2009 | Eur J Radiol2009，70，1： | 1 |
| 17 | Symptomatic partial rotator cuff tears:diagnostic performance of ultrasound and magnetic resonance imaging with surgical correlation显示文摘 | Vlychou M Dailiana Z Fotiadou A | | 0，，01： | 1 |
| 18 | Quantitatlve in vivo MRI evaluation of lumbar facet joints and interverte- bral discs using axial T2 Mapping 显示文摘 | Stelzeneder D Marianna A Vlychou M | 2011 | Eur Radiol2011，21，： | 1 |
| 19 | Primary lymphomas of bone显示文摘 | Kitsoulis P Vlychou M Papoudou-Bai A | 2006 | Anticancer Res2006，26，： | 1 |
| 20 | Imaging modali ties for renal artery stenosis in suspected renovascular hy- pertension:prospective intraindividual comparison of color doppler US,CT angiography,GD-enhanced MR angiogra- phy,and aigital substraction angiography显示文摘 | Rountas C Vlychou M Vassiou K | 2007 | Renal Fail-ure2007，29，3： | 1 |
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