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| 1 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 2 | Review of root dynamics in forest ecosystems grouped by climate,climatic forest type and species显示文摘 | Vogt K A Vogt D J Palmiotto P A | 1996 | Plant and Soil1996，187，： | 1 |
| 3 | Multi-destination trip patterns显示文摘 | Stewart S I Vogt C A | 1997 | Annals of Tourism Research1997，24，2： | 1 |
| 4 | An augmented reality system for MR image-guided needle biopsy:initial results in a swine model显示文摘 | Wacker F Vogt S Khamene A | 2006 | Radiology2006，，02： | 1 |
| 5 | Energy and radiation balance of a central European city 显示文摘 | Christen A Vogt R | 2004 | International Journal of Cli- matology2004，24，11： | 1 |
| 6 | Sex-related differences in IBS patients: central processing of visceral stimuli显示文摘 | Bruce D Naliboff Steve Berman Lin Chang Stuart W.G Derbyshire Brandall Suyenobu Brent A Vogt Mark Mandelkern Emeran A Mayer | 2003 | Gastroenterology2003，，7： | 1 |
| 7 | Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11显示文摘 | delmann A irsch S t al | 1996 | Hum Mol Genet1996，，7： | 1 |
| 8 | Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis显示文摘 | READ R W SZALAI A J VOGT S D | 2006 | Exp Eye Res2006，82，3： | 1 |
| 9 | Molecular Adaptations in Human Skeletal Muscle to Endurance Training Under Simulated Hypoxic Conditions 显示文摘 | VOGT M PUNTSCHART A GEISER J | 2001 | J Appl Physiol2001，，91： | 1 |
| 10 | Temporal dynamics of CO2 fluxes and profiles over a central European city 显示文摘 | Vogt R Christen A Rotach M W | 2006 | Theoretical and Applied Climatology2006，84，123： | 1 |
| 11 | Prolonged - release nicotinic acid forthe management of dyslipidemia an update in clouding re-sults from the NAUTILUS study 显示文摘 | Vogt A Kassner U | 2007 | Vas cul health riskmanag2007，3，4： | 1 |
| 12 | Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci显示文摘 | Gibaud A Vogt N Hadj - Hamou NS | 2010 | Hum Mol Genet2010，19，7： | 1 |
| 13 | The relationship between residents' attitudes toward tourism and tourism development options 显示文摘 | Andereck K L Vogt C A | 2000 | Journal of Travel research2000，39，1： | 1 |
| 14 | 显示文摘 | Mary T A Evans J S O Vogt T | 1996 | Science1996，，272： | 1 |
| 15 | Coagulation markers predict survival in cancer patients显示文摘 | HAEBERLI A VOGT A | 2002 | Thromb Haemost2002，88，5： | 1 |
| 16 | Different profile of antioxidative capacity results in pulmonary dysfunction and amplified inflammatory response after CABG surgery显示文摘 | Vogt S Sattler A Sirat AS | 2007 | J Surg Res2007，139，1： | 1 |
| 17 | A non-peptide mimetic of Ras-CAAX: seleetive inhibition of famesyltransferase and Ras processing 显示文摘 | Vogt A Qian YM Blaskovich MA | 1995 | J Biol Chem1995，270，2： | 1 |
| 18 | Human Y chromosome azoospermia factors(AZF)mapped to different subregions in Yq11显示文摘 | Vogt PH Edelmann A Kirsch S | 1996 | Human Molecular Genetics1996，5，7： | 1 |
| 19 | Radiation exposure during cardiac CT:effective doses at multi-detector row CT and electron-beam CT显示文摘 | Hunold P Vogt F M Schmermund A | 2003 | Radiology2003，226，： | 1 |
| 20 | Impact of early perfusion status of the infaet-re|ated artery on short-term mortality after thrombolysis for acute myocardial infarction:retrospective analysis of four German multicenter studies显示文摘 | Vogt A Von Essen R Tebbe U | 1993 | J Am Coll Cardiol1993，21，6： | 1 |
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