| 5 | Route, origin & valence matter: towards sophisticated nextgeneration vaccines to cope with the COVID-19 pandemic显示文摘In a recent study published in Cell,Afkhami and colleagues systematically compared different routes of vaccine delivery,origin of the vaccine platform as well as valence of the vaccine and demonstrated that the respiratory mucosal delivery of a trivalent chimpanzee’s adenovirus(Ad)-vectored vaccine is superior to any other of the tested conditions in inducing broadlyacting immunity and protection against current severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and possibly future variants of concern(VOC).1 The ongoing global coronavirus disease 2019(COVID-19)pandemic caused by SARS-CoV-2 has forced an uniquely fast development of novel mRNA-and vector-based vaccines. | Julia Volckmar Lars Melcher Dunja Bruder | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
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