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| 1 | Potential pathophysiological role for the vitamin D deficiency in essential hypertension显示文摘Vitamin D deficiency has been indicated as a pandemicemerging public health problem. In addition to the well-known role on calcium-phosphorus homeostasis in thebone, vitamin D-mediated processes have been recentlyinvestigated on other diseases, such as infections, can-cer and cardiovascular diseases. Recently, both the dis-covery of paracrine actions of vitamin D(recognized as'local vitamin D system') and the link of vitamin D with renin-angiotensin-aldosterone system and the fibroblast growth factor 23/klotho pathways highlighted its ac-tive cardiovascular activity. Focusing on hypertension, this review summarizes the more recent experimental evidence involving the vitamin D system and deficiency in the cardiovascular pathophysiology. In particular, we updated the vascular synthesis/catabolism of vitamin D and its complex interactions between the various endocrine networks involved in the regulation of blood pressure in humans. On the other hand, the conflicting results emerged from the comparison between obser-vational and interventional studies emphasize the frag-mentary nature of our knowledge in the field of vitamin D and hypertension, strongly suggesting the need of further researches in this field. | Federico Carbone Fran?ois Mach Nicolas Vuilleumier Fabrizio Montecucco | 2014 | World Journal of Cardiology2014，6，5： | 17 |
| 2 | Autoantibodies to apolipoprotein A-1 as a biomarker of cardiovascular autoimmunity显示文摘Immune-driven inflammation plays an important part inatherogenesis and is therefore believed to be key to thedevelopment of cardiovascular disease(CVD), whichis currently the leading cause of death in the Westernworld. By fulfilling some of the Koch postulates, athero-genesis has even been proposed to be considered as anautoimmune disease, raising the hope that CVD couldbe prevented by immunomodulation. Nevertheless,the role of the immune system and autoimmune reac-tions in atherosclerosis appear to be a double edged-sword, with both pro-atherogenic and anti-atherogenicattributes. Hence, if immunomodulation is to becomea therapeutic option for atherosclerosis and CVD, it willbe crucial to correctly identify patients who might ben-efit from targeted suppression of deleterious autoim-mune responses. This could be achieved, for example, by the detection of disease-associated autoantibodies. In this work, we will review the currently available clini-cal, in vitro, and animal studies dedicated to autoan-tibodies against apolipoprotein A-1(anti-apoA-1 IgG), the major proteic fraction of high density lipoprotein. Current clinical studies indicate that high levels of anti-apoA-1 IgG are associated with a worse cardiovascular prognosis. In addition, in vitro and animal studies indi-cate a pro-inflammatory and pro-atherogenic role, sup-porting the hypothesis that these autoantibodies may play a direct causal role in CVD, and furthermore that they could potentially represent a therapeutic target for CVD in the future. | Nicolas Vuilleumier Fabrizio Montecucco Oliver Hartley | 2014 | World Journal of Cardiology2014，6，5： | 5 |
| 3 | Left atrial thrombosis in an anticoagulated patient after bioprosthetic valve replacement:Report of a case显示文摘We present the case of a 74 year old woman suffering from severe mitral valve incompetence and rapid atrial fibrillation. After an appropriate vitamin K antagonist(VKA) therapy, the patient underwent mitral valve replacement by bioprosthesis. Then, the patient was rehospitalized for jaundice. Suspecting hepatotoxicity, VKA was discontinued and fondaparinux was started. During this treatment, the patient developed a symptomatic atrial thrombus. After exclusion of a hepatic disease, VKA was re-established with hemodynamic and liver enzymes normalization and atrial thrombus resolution. Caution has to be used when considering fondaparinux as an alternative strategy to VKA in patients with multiple thrombotic risk factors. | Gian Marco Rosa Antonello Parodi Ulrico Dorighi Federico Carbone Franois Mach Alessandra Quercioli Fabrizio Montecucco Nicolas Vuilleumier Manrico Balbi Claudio Brunelli | 2014 | World Journal of Clinical Cases2014，2，1： | 2 |
| 4 | Statin Treatment Is Associated with Reduction in Serum Levels of Receptor Activator of NF- κ B Ligand and Neutrophil Activation in Patients with Severe Carotid Stenosis显示文摘 | Sébastien Lenglet Alessandra Quercioli Mathias Fabre Katia Galan Graziano Pelli Alessio Nencioni Inga Bauer Aldo Pende Magaly Python Maria Bertolotto Giovanni Spinella Bianca Pane Domenico Palombo Franco Dallegri Fran?ois Mach Nicolas Vuilleumier Fabrizio | 2014 | Mediators of Inflammation2014，，： | 2 |
| 5 | Explicit and implicit perception of illusory contours in unilateral spatial neglect: behavioural and anatomical correlates of preattentive grouping mechanisms 显示文摘 | Vuilleumier P Valenza N Landis T | 2001 | Neuropsychologia2001，39，6： | 1 |
| 6 | How patch configuration affects the impact of disturbances on metapopulation persistence显示文摘 | Vuilleumier S Wilcox C | 2007 | Theoretical Population Biology2007，72，： | 1 |
| 7 | Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predic-tors of major adverse cardiovascular events after carotid endarterectomy 显示文摘 | Vuilleumier N Montecuceo F Spinella G | 2013 | Thromb Haemost2013，109，4： | 1 |
| 8 | Effects of attention and emotion on face processing in the human brain:An event-related fMRI study显示文摘 | Vuilleumier P Armony JL Driver J | 2001 | Neuron2001，30，： | 1 |
| 9 | Auto-antibodies as Emergent Prognostic Markers and Possible Mediators of Ischemic Cardiovascular Diseases显示文摘 | P. Roux-Lombard S. Pagano F. Montecucco N. Satta N. Vuilleumier | 2013 | Clinical Reviews in Allergy & Immunology2013，，1： | 1 |
| 10 | Methylobacterium genome sequences:A reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources 显示文摘 | Vuilleumier S Chistoserdova L Lee M C | 2009 | Plos one2009，4，5： | 1 |
| 11 | High Prevalence of Anti‐Apolipoprotein/A‐1 Autoantibodies in Maintenance Hemodialysis and Association With Dialysis Vintage显示文摘 | Menno Pruijm Jan Schmidtko Anthony Aho Sabrina Pagano Pascale Roux‐Lombard Daniel Teta Michel Burnier Nicolas Vuilleumier | 2012 | Therapeutic Apheresis and Dialysis2012，，6： | 1 |
| 12 | Unilateral spatial neglect recovery after sequential strokes 显示文摘 | Vuilleumier P Hester D Assal G | 1996 | Neurology1996，46，： | 1 |
| 13 | The Role of Emergency Laparoscopy in Abdominal Pain Syndrome and in the Assessment of Abdominal Trauma显示文摘 | Vuilleumier H Cuttat J F Wassmer F A | 1994 | Schweiz Med Wochenschr1994，124，22： | 1 |
| 14 | The origin and evolutionary development of heterostyly in angiosperms显示文摘 | Vuilleumier B | 1967 | Evolution1967，21，210： | 1 |
| 15 | Autoantibodies to apolipoprotein A-1 in cardiovascular diseases:current perspectives 显示文摘 | Teixeira PC Cutler P Vuilleumier N | 2012 | Clin Dev Immunol2012，2012，86： | 1 |
| 16 | Pilonidal sinus:how to choose between excision and granulation versus excision and primary closure?Study of a series of 141 patients operated on 1991 to 1995显示文摘 | Perruchoud C Vuilleumier H Civel JC | 2002 | Swiss Surg2002，8，6： | 1 |
| 17 | Measuring the effects of pesticides on bacterial communities in soil: A critical review显示文摘 | Imfeld G Vuilleumier S | 2012 | European Journal of Soil Biology2012，49，： | 1 |
| 18 | CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients:results from a phase Ⅱ显示文摘 | Voelter V Zouhair A Vuilleumier H | | 0，，： | 1 |
| 19 | Persistent affec- tive biases in human amygdala response following implicit priming with negative emotion concepts显示文摘 | PICHON S RIEGER SW VUILLEUMIER P | 2012 | Neuroimage2012，62，3： | 1 |
| 20 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
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