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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Price-driven coordination method for solving plant wide MPC problems显示文摘 | Cheng R Forbes J Yip W | 2007 | Journal of Process Control2007，17，5： | 1 |
| 3 | Market,Structure,and Performance in European Banking显示文摘 | Molyneux P W Forbes | 1995 | Applied Economics1995，，27： | 1 |
| 4 | Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease显示文摘 | Burn W C Twigg S M Forbes J M | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 5 | Photovoltaie solar cells : an overview of state-of-the-art cell development and environmental issues 显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 6 | Mucociliary flow in the trachea during anesthesia with enflurane Ether,nitrous oxide,and morphine 显示文摘 | Forbes A R Horrigan R W | 1977 | Anesthesiology1977，46，5： | 1 |
| 7 | An 11-year experience of enterocutaneous fistula 显示文摘 | Hollington P Mawdsley J Lim W Gabe SM Forbes A Windsor AJ | 2004 | Br J Surg2004，91，12： | 1 |
| 8 | Photovoltaic solar cells: an overview of state-of-the-art cell development and environmental issues显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 9 | Isentropic compression loading of octahydro-1,3,5,7-tetranitro-1, 3,5,7-tetrazocine (HMX) and the pressure-induced phase transition at 27 GPa 显示文摘 | Hare D E Forbes J W Reisman D B | 2004 | Appl Phys Lett2004，85，6： | 1 |
| 10 | Synopic and me soscale aspects of an Appalachian ice storm associated with cold-air damming显示文摘 | Forbes G S Anthes R A Thomson D W | 1987 | Mon Wea Rev1987，115，： | 1 |
| 11 | Photovoltaic solar ceils: An overview of state of the art cell development and environmental issues显示文摘 | Miles R W Hynes K M Forbes I | 2005 | Prog Crystal Growth Charact Ma- ter2005，51，123： | 1 |
| 12 | 显示文摘 | Forbes D C Davis J H | 2001 | Tetra Lett2001，42，35： | 1 |
| 13 | Chemoattraction and chemorepulsion of Strongy- loides stercoralis infective larvae on a sodium chloride gradient is mediated by amphidial neuron pairs ASE and ASH, respectively 显示文摘 | FORBES W M ASHTON F T BOSTON R | 2004 | Vet Parasitol2004，120，3： | 1 |
| 14 | An enumeration of all the plants known from China proper, Formosa, Hainap, Corea, the Luchu Archipelago ,and the Island of Hongkong, together with their distribution and synonymy显示文摘 | Forbes F B Hemsley W B | | J Linnean Soc Bot0，26，： | 1 |
| 15 | Rate of knee cartilage loss af- ter partial meniscectomy 显示文摘 | Cicuttini FM Forbes A Yuanyuan W | 2002 | J Rheumatol2002，9，： | 1 |
| 16 | Rate of knee cartilage loss after partial meniscectomy显示文摘 | Cicuttini F M Forbes A Yuanyuan W | 2002 | J Rheumatol2002，29，9： | 1 |
| 17 | Free surface flow over a semicircular obstruction显示文摘 | FORBES L K SCHWARTZ L W | 1982 | J Fluid Mech1982，114，5： | 1 |
| 18 | Effect of body mass index on recurrences in tamoxifen and anastrozole treated women:an exploratory analysis from the ATAC trial显示文摘 | Sestak I Distler W Forbes JF | | 0，，21： | 1 |
| 19 | Adult-onset deficiency in growth hormone andinsulin-like growth factor-1decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis显示文摘 | Lichtenwalner R J Forbes M E Sonntag W E | 2006 | J Neurosci Res2006，83，2： | 1 |
| 20 | Loss reserve valuations and financial results in non-life insurance显示文摘 | Forbes S W | 1971 | Journal of risk and insurance1971，，38： | 1 |
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