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| 1 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Microstructure characterization of a polymer/metal mechanical alloy显示文摘 | W J D Shaw H J Danilkewich | 1997 | Microstructure Science1997，25，： | 2 |
| 4 | The dynamics of a harmonically excited system having rigid amplitude constraints显示文摘 | | 1985 | ASME Journal of Applied Mechanics1985，52，2： | 1 |
| 5 | Determination of global kinetics of coal volatiles com- bustion 显示文摘 | Shaw David W Zhu Xuedong Misra Mahendra K | 1991 | Symposium (International) on Combustion1991，28，1： | 1 |
| 6 | Nonlinear Normal modes, Invariance and modal dynamics approximations of nonlinear systems 显示文摘 | Nicolas B Pierre C Shaw S W | 1995 | Nonlinear Dynamics1995，8，： | 1 |
| 7 | Effect of retinol palmitate on ovulation rate and embryo quality in superovulated cattle显示文摘 | Shaw DW Farin P W Washburn S P | 1995 | Theriogenology1995，44，： | 1 |
| 8 | A periodically forced Impact oscillator with large dissipation显示文摘 | Shaw S W Holmes P J | 1983 | Journal of Applied Mechanics1983，50，： | 1 |
| 9 | Innovative Approaches to Water Allocation : The Potential for Water Markets 显示文摘 | Howe C W Schurmeier D R Shaw W D | 1986 | Water Re- sources Research1986，22，4： | 1 |
| 10 | Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes 显示文摘 | Shaw GM Iovannisci DM Yang W | 2005 | Am J Med Genet A2005，138，1： | 1 |
| 11 | Performance Measurement and Management: A Tool for Strategy Execution 显示文摘 | CRAIG ERIC SCHNEIER DOUGLAS G SHAW RICHARD W BEATTY | 1991 | Human Resource Management1991，30，3： | 1 |
| 12 | Periodically forced linear oscillator with impacts: chaos and long-period motions 显示文摘 | Shaw S W Holmes P J | 1989 | Physical Review Letters1989，51，8： | 1 |
| 13 | Using actual andcontingent behavior data with differing levels of time aggregation to modelrecreation demand显示文摘 | CAMERON T A SHAW W D RAGLAND S E | 1996 | Journal of Agricultural and Resource Economics1996，21，： | 1 |
| 14 | Applica- tion of global methods for analyzing dynamical systems to ship rolling motion and capsizing 显示文摘 | FALZARANO J M SHAW S W TROESCH A W | 1992 | International Journal of Bifurcation and Chaos1992，2，1： | 1 |
| 15 | Write-ofIs as Accounting Procedures to Manage perceptions 显示文摘 | Elliott J Shaw W H | 1988 | Joumal of Accounting Research1988，，： | 1 |
| 16 | The decomposition of urea in aque-ous media显示文摘 | Shaw W R Bordea J J | 1955 | Journal of the American Chemical Society1955，77，： | 1 |
| 17 | Flow routing in large-scale models using vector addition 显示文摘 | SHAW D MARTZ L W PIETRONIRO A | 2005 | Journal of Hydrology2005，307，： | 1 |
| 18 | Improving filtration of cryptosporidium 显示文摘 | Shaw K Steven W Koopman B | 2000 | J AWWA2000，92，11： | 1 |
| 19 | Nonlinear normal modes and invariant manifolds 显示文摘 | Shaw S W Peirre C | 1991 | Journal of Sound and Vibration1991，150，1： | 1 |
| 20 | Estimating the cost of leisure time for recreation demand models 显示文摘 | Feather P Shaw W D | 1999 | Journal of Environmental Economics and Management1999，38，： | 1 |
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