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	题名	作者	年代	出处	被引量
1	Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.	Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki	2006	World Journal of Gastroenterology2006，12，40：	3
2	An approach to muhimodal biomedical image registration utilizing par- ticle swarm optimization显示文摘	WACHOWIAK M P SMOLIKOVA R ZHENG Y F	2004	IEEE Trans Evol Comput2004，8，3：	1
3	An approach to multimodal biomedical image registration utilizing particle swarm optimization显示文摘	Wachowiak M P Smolikova R Zhong Y	2004	IEEE Transaction on Evolutionary Computation2004，8，3：	1
4	An approach to multimodal biomedical image registration utilizing particle swarm optimization显示文摘	Wachowiak M P Smolikova R Zheng Y F	2004	IEEE Transaction on Evolutionary Computation2004，8，3：	1
5	Ambulatory long-term pH monitoring in pigs显示文摘	K. A. Gawad R. Wachowiak C. Rempf W. J. Tiefenbacher T. Strate E. G. Achilles C. Bl?chle J. R. Izbicki	2003	Surgical Endoscopy2003，，10：	1
6	Direct observation of internal spin structure of magnetic vortex cores显示文摘	WACHOWIAK A WIEBE J BODE M	2002	Science2002，298，5593：	1
7	Psychosocial factors and assess-ment in cardiac rehabilitation 显示文摘	Shen BJ Wachowiak PS Brooks LG	2005	Eura Medicophys2005，41，1：	1
8	Direct observation of internal spin structure of masnetic vortex cores 显示文摘	WACHOWIAK A WIEBE J BODE M	2002	Science2002，298，5593：	1
9	Adaptive finite element technique for cutting in surgical simulation:Medical Imaging 2005显示文摘	Zhong HL Wachowiak MP Peters	2005	Visualization Image-Guided Procedures and Display San Diego CA: 2005-02-152005，17，：	1
10	Direct observa- tion of internal spin structure of magnetic vortex cores 显示文摘	Wachowiak A Wiebe J Bode M	2002	Science2002，298，5593：	1
11	Psychosocial factors and assess ment in cardiac rehabilitation显示文摘	Shen BJ Wachowiak PS Brooks LG	2005	Eura Medicophys2005，41，1：	1
12	High performance medical image registration using new optimization techniques显示文摘	PETERS T M	2006	IEEE Transactions on Information Technology in Biomedicine2006，10，2：	1
13	Relationship between hyperspectral measurements and mangrove leaf nitrogen concentrations显示文摘	Zhang C H Kovacs J M Wachowiak M P	2013	Remote Sensing2013，5，2：	1
14	An approach to multimodal bio- medical image registration utilizing particle swarm optimization显示文摘	MARK E WACHOWIAK	2004	IEEE Transactions on Evolutionary Computation2004，8，3：	1
15	Estimation of K distribution parameters using neural networks显示文摘	Wachowiak M P Smol kov R Zurada J M Elmaghraby A S	2002	IEEE Transactions on Biomedical Engineering2002，49，6：	1
16	An approach to multimodal biomedical image registration utilizing particle swarm optimization显示文摘	WACHOWIAK M P SMOLFKOVA R		0，，03：	1
17	An approach to multimodal biomedical image registration utilizing particle swarm optimization 显示文摘	Wachowiak MP Smolikova R Zheng Y	2004	IEEE Transactions on Evolutionary Computation2004，8，3：	1
18	An approach to multimodal biomedical image registration utilizing particle swarm optimization显示文摘	WACHOWIAK M P SMOLIKOVR ZURADA J M	2004	IEEE Trans on Evolutionary Computation2004，8，3：	1
19	Epstein - Barr virus (EBV) infection in B - cell non - Hodgkin's lymphomas in children: Virus latency and its correlation with CD21 and CD23 molecules显示文摘	Kasprzak A Spachacz R Wachowiak J	2007	Folia Histochem Cytobiol2007，45，3：	1
20	L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma显示文摘瞄准:在胰腺的神经内分泌肿瘤决定 L1 的表示并且相关它与这个肿瘤的分类。方法:我们回顾地在原发性瘤或转移的石蜡节上由免疫组织化学在胰腺的神经内分泌肿瘤的 63 种情况中分析了 L1 表示。染色被过氧化物酶技术对人的 L1 与单音的同种细胞的抗体 UJ127.11 执行。所有肿瘤被分类根据分类同样区分得好的神经内分泌肿瘤和癌或糟糕区分的神经内分泌癌。结果:L1 在 5 被检测(7.9%) 63 个胰腺的神经内分泌肿瘤。(44.4%) 四 9 糟糕区分的癌表示了 L1。相反,仅仅(1.9%) 1 为 L1 54 个区分得好的肿瘤或癌是积极的。没有表示在正常胰腺的织物的 Langerhans 小岛房间被发现。生气桌子分析显示出在 L1 表示和胰(P<0.01 ) 的神经内分泌肿瘤的分类之间的一个重要协会。结论:L1 明确地在被知道有最糟的预后的糟糕区分的胰腺的神经内分泌癌被表示。L1 可能是为与胰腺的神经内分泌癌诊断的病人的风险预言的一个标记。	Jussuf T Kaifi Ulrich Zinnkann Emre F Yekebas Paulus G Schurr Uta Reichelt Robin Wachowiak Henning C Fiegel Susann Petri Melitta Schachner Jakob RIzbicki	2006	World Journal of Gastroenterology2006，12，1：	1

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