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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | Parent and medical professional willingness to enroll children in a hypothetical pediatric optic neuritis treatment trial 显示文摘 | Waldman AT Shumski MJ Jerrehian M | 2011 | Front Neurol2011，，2： | 1 |
| 3 | Transformational leadership and the falling dominoes effect显示文摘 | BASS B M WALDMAN D A AVOLIO B J | 1987 | Group&Organization Management1987，12，1： | 1 |
| 4 | Chemical composition of acid fog显示文摘 | Waldman J M Munger J W Jacob D J | 1982 | Science1982，218，： | 1 |
| 5 | Wintertime measurements of aerosol acidity and trace elements in Wuhan, a City in Central China显示文摘 | Lioy P J Zelenka M | 1991 | Atmosphere Environment1991，25，1： | 1 |
| 6 | Adultminimal-change disease:clinical characteristics,treatment,and outcomes显示文摘 | Waldman M Crew RJ Valeri A | 2007 | Clin J Am Soc Nephrol2007，2，3： | 1 |
| 7 | Effect of zoledrnnate on bone quality in the treatment of aseptic loosening of hip arthroplasty in the dog 显示文摘 | Wise LM Waldman SD Kasra M | 2005 | Calcif Tissue Int2005，6，： | 1 |
| 8 | Job assignments signalling and efficiency显示文摘 | WALDMAN M | 1984 | Rand Journal of Economics1984，15，： | 1 |
| 9 | Infected total knee arthroplasty treated by arthroscopic irrigation and de- bridement 显示文摘 | Waldman B J Hostin E Mont M A | 2000 | J Arthroplasty2000，15，4： | 1 |
| 10 | Long term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro显示文摘 | WALDMAN S D SPITERI C G GRYNPAS M D | 2003 | Journal of Orthopae- dic Research= Official Publication of the Orthopaedic Research Society2003，21，4： | 1 |
| 11 | Planned obsolescence and the R&D decision 显示文摘 | WALDMAN M | 1996 | RAND Journal of Economics1996，27，3： | 1 |
| 12 | Thermal properties of high density polyethylene composites with natural fibres:Coupling agent effect显示文摘 | Arau'jo J R Waldman W R De Paoli M A | 2008 | Polymer Degradation and Stability2008，93，10： | 1 |
| 13 | Biological diversity - an overview显示文摘 | Waldman M Shevah Y | 2000 | Water Air & Soil Pollution2000，123，： | 1 |
| 14 | Hormonal regulation morphogenesis of and cold-resistance显示文摘 | Waldman M Dovrar A | 1975 | J Exp Bot1975，26，： | 1 |
| 15 | Hormonal regulation of morphogenesis and cold- resistance显示文摘 | Waldman M Rikin A Dovrat A | 1975 | J Exp Bot1975，26，： | 1 |
| 16 | The Effects of Increased Copyright Protection:An Analytic Approach显示文摘 | Novos I E Waldman M | 1984 | The Journal of Political Economy1984，92，2： | 1 |
| 17 | Terahertz inverse synthetic aperture radar (ISAR) imaging with a quantum cascade laser transmitter显示文摘 | Andriy A D Thomas M G Waldman J | 2010 | Optics Express2010，18，16： | 1 |
| 18 | Ex Ante versus Ex Post Optimal Promotion Rules: The Case of Internal Promotion 显示文摘 | Waldman M | 2003 | Economic Inquiry2003，41，1： | 1 |
| 19 | Parvovirus B19 and the kidney显示文摘 | Waldman M Kopp JB | 2007 | Clin J Am Soc Nephrol2007，21，： | 1 |
| 20 | Job Assignments, Signaling and Efficiency显示文摘 | Waldman M | 1984 | Rand Journal of Economics1984，，： | 1 |
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