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| 1 | Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa... | YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 42 |
| 2 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 3 | Progress of Air Pollution Control in China and Its Challenges and Opportunities in the Ecological Civilization Era显示文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously. | Xi Lu Shaojun Zhang Jia Xing Yunjie Wang Wenhui Chen Dian Ding Ye Wu Shuxiao Wang Lei Duan Jiming Hao | 2020 | Engineering2020，6，12： | 24 |
| 4 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 5 | Evaluation of health benefit using Ben MAP-CE with an integrated scheme of model and monitor data during Guangzhou Asian Games显示文摘Guangzhou is the capital and largest city(land area:7287 km2)of Guangdong province in South China.The air quality in Guangzhou typically worsens in November due to unfavorable meteorological conditions for pollutant dispersion.During the Guangzhou Asian Games in November 2010,the Guangzhou government carried out a number of emission control measures that significantly improved the air quality.In this paper,we estimated the acute health outcome changes related to the air quality improvement during the 2010 Guangzhou Asian Games using a next-generation,fully-integrated assessment system for air quality and health benefits.This advanced system generates air quality data by fusing model and monitoring data instead of using monitoring data alone,which provides more reliable results.The air quality estimates retain the spatial distribution of model results while calibrating the value with observations.The results show that the mean PM_2.5concentration in November 2010 decreased by 3.5μg/m^3 compared to that in 2009 due to the emission control measures.From the analysis,we estimate that the air quality improvement avoided 106 premature deaths,1869 cases of hospital admission,and 20,026 cases of outpatient visits.The overall cost benefit of the improved air quality is estimated to be 165 million CNY,with the avoided premature death contributing 90%of this figure.The research demonstrates that Ben MAP-CE is capable of assessing the health and cost benefits of air pollution control for sound policy making. | Dian Ding Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua Fu Jian Gao Shuang Deng Junping Xie Xuezhen Qiu | 2016 | Journal of Environmental Sciences2016，28，4： | 13 |
| 6 | Immediate Therapeutic Outcomes and Medium-term Follow-up of Percutaneous Balloon Pulmonary Valvuloplasty in Infants with Pulmonary Valve Stenosis: A Single-center Retrospective Study显示文摘 | Dian Hong Ming-Yang Qian Zhi-Wei Zhang Shu-Shui Wang Jun-Jie Li Yi-Fan Li Tian Liu | 2017 | Chinese Medical Journal2017，，23： | 13 |
| 7 | Design and demonstration of a next-generation air quality attainment assessment system for PM_(2.5)and O_3显示文摘Due to the increasingly stringent standards, it is important to assess whether the proposed emission reduction will result in ambient concentrations that meet the standards. The Software for Model Attainment Test—Community Edition(SMAT-CE) is developed for demonstrating attainment of air quality standards of O3 and PM2.5. SMAT-CE improves computational efficiency and provides a number of advanced visualization and analytical functionalities on an integrated GIS platform. SMAT-CE incorporates historical measurements of air quality parameters and simulated air pollutant concentrations under a number of emission inventory scenarios to project the level of compliance to air quality standards in a targeted future year. An application case study of the software based on the U.S. National Ambient Air Quality Standards(NAAQS) shows that SMAT-CE is capable of demonstrating the air quality attainment of annual PM2.5and 8-hour O3 for a proposed emission control policy. | Hua Wang Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua S.Fu Jian Gao Shuang Deng Junping Xie Dian Ding Xuezhen Qiu Shicheng Long | 2015 | Journal of Environmental Sciences2015，27，3： | 11 |
| 8 | Derivation of soil Pb/Cd/As thresholds for safety of vegetable planting: A case study for pakchoi in Guangdong Province,China显示文摘Regional guidelines for soil heavy metals,in conjunction with specific crops,are proposed to better assess soil environmental quality.In this study,large amounts of soils with different levels of Pb/Cd/As pollution were collected in Guangdong Province,China,to carry out a pot experiment,which was closer to the actual situation and properties of the heavy metal contaminated soils.Taking the widely planted vegetable pakchoi as the research object,we analyzed the correlations between the Pb/Cd/As concentrations in pakchoi and the total or available soil Pb/Cd/As concentrations and established their optimal regression equations.And then,the total and available soil Pb/Cd/As thresholds for pakchoi were calculated according to the allowable Pb/Cd/As limits in pakchoi and were compared with the current soil assessment standards.Furthermore,a lot of paired vegetable-soil samples in field were collected and their pollution situations were assessed by both the current limit thresholds and the calculated thresholds.Obviously,it was more consistent to assess the Cd and As pollution situation of the vegetable and soil samples with the calculated soil thresholds than the current soil assessment thresholds.It further proved that it was necessary to explore the soil heavy metal thresholds for safety of vegetable in specific regions,which would be more scientific and practical to guide safety production of local agricultural products and effective utilization of soil resources. | LI Fu-rong WEN Dian WANG Fu-hua SUN Fang-fang WANG Xu DU Ying-qiong LIU Xiang-xiang WAN Kai | 2019 | Journal of Integrative Agriculture2019，18，1： | 8 |
| 9 | Development of an integrated policy making tool for assessing air quality and human health benefits of air pollution control显示文摘有效空气质量管理是批评的保护公共健康免受空气污染的不利影响的伤害。为了评估空气污染的有效性,控制策略, US 环境保护机构(美国 EPA )开发了软件让模型成就测试社区编辑( SMAT-CE )估计排放减小的空气质量成就,并且印射的环境好处和编辑( BenMAP-CE )分别地空气质量改进有益于评估健康和经济的分析节目社区。后来科学的决策要求及时、协调的信息,开发在 SMAT-CE 之间的连接,进一个综合评价平台的 BenMAP-CE 是合乎需要的。探讨这需要,连接 SMAT-CE 到 BenMAP-CE 的一个新模块被开发了并且测试。新模块优化对优秀、人的健康为建议空气污染控制策略有益于的空气的评价。它也实现没有损害精确性,显著地提高计算效率的一个优化数据 gridding 算法。综合软件包裹的性能通过案例研究被表明评估质量和联系经济下午 2.5 的公民级的控制策略有益于的空气。案例研究的结果证明建议排放减小基于 US 国家周围的空气质量标准从 379 ~ 25 减少 nonattainment 地点的数字,从改进公共健康每年多于经济好处的 3340 亿美元导致。在这研究的基于科学的软件工具的集成提高为政策制造者开发有效、优化的排放控制策略的效率。 | Xuezhen QIU Yun ZHU Carey JANG Che-Jen LIN Shuxiao WANG Joshua FU Junping XIE Jiandong WANG Dian DING Shicheng LONG | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 6 |
| 10 | Trends in Extremes of Surface Humidity, Temperature, and Summertime Heat Stress in China显示文摘In the past half century, the mean summertime temperature in China has increased, with nights warm- ing more than days. Using surface station observations, we show that the frequency of extreme heat-stress events in China, caused by extremely hot and humid days as well as by heatwaves lasting for a few days, has increased over the period from 1951 to 1994 When humidity is high, hot weather can cause heat stress in humans. The increased heatrstress trend may pose a public health | Julian X.L. Wang and Dian J. Gaffen NOAA/ Air Resources Laboratory, Silver Spring, MD, 20910, USA | 2001 | Advances in Atmospheric Sciences2001，18，5： | 6 |
| 11 | Antibody-drug conjugates:Recent advances in linker chemistry显示文摘Antibody-drug conjugates(ADCs)are gradually revolutionizing clinical cancer therapy.The antibody-drug conjugate linker molecule determines both the efficacy and the adverse effects,and so has a major influence on the fate of ADCs.An ideal linker should be stable in the circulatory system and release the cytotoxic payload specifically in the tumor.However,existing linkers often release payloads nonspecifically and inevitably lead to off-target toxicity.This defect is becoming an increasingly important factor that restricts the development of ADCs.The pursuit of ADCs with optimal therapeutic windows has resulted in remarkable progress in the discovery and development of novel linkers.The present review summarizes the advance of the chemical trigger,linker-antibody attachment and linker-payload attachment over the last 5 years,and describes the ADMET properties of ADCs.This work also helps clarify future developmental directions for the linkers. | Zheng Su Dian Xiao Fei Xie Lianqi Liu Yanming Wang Shiyong Fan Xinbo Zhou Song Li | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 12 | Clinical pharmacology considerations in biologics development显示文摘Biologics 包括 monoclonal 抗体(mAbs ) 和象 cytokines 和生长荷尔蒙那样的另外的治疗学的蛋白质,与小分子相比有唯一的特征。这篇论文为阶段 II/III 临床的试用从一个机械学的观点,为 first-in-human (FIH ) 的剂量学习的开始的决心,和 dosing 政体优化从 biologics 的 pharmacokinetics (PK ) 的概述开始。随后,典型临床的药理学发出相应小径因为 biologics 开发被总结,包括在特定的人口的药药相互作用, QTc 延伸, immunogenicity,和研究。在 biologics,他们的 pharmacokinetic 和 pharmacodynamic 特征,和相应临床的药理学策略的分子的结构之间的关系在一张图解的图被总结并且描绘。 | Liang ZHAO Tian-hua REN Diane D WANG | 2012 | Acta Pharmacologica Sinica2012，33，11： | 5 |
| 13 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 14 | Robust microwave absorption in silver-cobalt hollow microspheres with heterointerfaces and electric-magnetic synergism:Towards achieving lightweight and absorption-type microwave shielding composites显示文摘Lightweight and high-efficiency microwave shielding materials based on high absorption loss are the hotspot of current research.Herein,the silver-cobalt bimetallic hollow microspheres(Ag-Co-HM)with low reflection loss and broadband absorption efficiency were fabricated and then used to construct bimetallic hollow structures in polydimethylsiloxane/carbon nanotube composites(PDMS/CNT)to obtain the lightweight and absorption-type microwave shielding composites.The microwave absorption of Ag-Co-HM and the microwave shielding effectiveness(SE T)of the PDMS/CNT/Ag-Co-HM composites was evaluated and discussed.The Ag-Co-HM with a molar ratio(Co/Ag)of 2.07 exhibited a low reflection loss as-46.6 dB at a thickness of 2.6 mm,and an effective absorption bandwidth of 8.40 GHz.The SE T of the PDMS/CNT composites was greatly enhanced by the incorporation of the Ag-Co-HM.Furthermore,the absorption coefficient(A)was also improved by adding the Ag-Co-HM and was much higher than the reflection coefficient.The composites exhibited absorption-type microwave shielding composites.For example,the average microwave SE T of 59.4 dB and A value of 0.78 are achieved in the PDMS/CNT/Ag-Co-HM composites containing 5 wt%CNTs and 10 wt%Ag-Co-HMs,which are much higher than the cor-responding values of 33.7 dB and 0.63 in the PDMS/CNT composites with only 5 wt%CNTs.In addition,the hollow structure of Ag-Co-HM endows the PDMS/CNT/Ag-Co-HM composites to have a low density. | Dian Yang Jun-Ru Tao Yi Yang Qian-Ming He Ming Wang | 2023 | Journal of Materials Science & Technology2023，，7： | 4 |
| 15 | A Radio-Telemetry System for Navigation and Recording Neuronal Activity in Free-Roaming Rats显示文摘 | Dian Zhang Yanling Dong Megan Li Houjun Wang | 2012 | Journal of Bionic Engineering2012，9，4： | 4 |
| 16 | Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma显示文摘 | Xiang‐Ming Lao Guangyu Luo Liang‐Tao Ye Cheng Luo Ming Shi Dian Wang Rongping Guo Minshan Chen Shengping Li Xiaojun Lin Yunfei Yuan | 2013 | Liver Int2013，，4： | 3 |
| 17 | A Family of Nonnormal Cayley Digraphs | Yan Quan FENG Dian Jun WANG Jing Lin CHEN | 2001 | Acta Mathematica Sinica,English Series2001，17，1： | 3 |
| 18 | Modified frontolateral partial laryngectomy operation: combined muscle-pedicle hyoid bone and thyrohyoid membrane flap in laryngeal reconstruction显示文摘Objective: Laryngeal reconstruction is needed to preserve laryngeal function in patients who have undergone extensive vertical or frontal partial laryngectomy. However, the procedure remains a difficult challenge. Several reconstruction techniques have been described, but these techniques pose risks of complications such as laryngeal stenosis. This study aimed to evaluate the postoperative course and functional outcomes of a new technique that combined a muscle-pedicle hyoid bone and a thyrohyoid flap during laryngeal reconstruction after tumor resection. Methods: Four patients underwent extensive vertical partial or frontal partial laryngectomy for cancer. After tumor resection, laryngeal reconstruction was performed using the proposed technique. Postoperative recovery time, complications, and oncologic results were evaluated. Results: The four patients were successfully treated with the proposed technique. No dyspnea, dysphagia, or death occurred during the postoperative course. Decannulation was performed after a median of 3 days. The average postoperative hospital stay was 7 days. Short-term postoperative functional recovery was normal. No laryngeal stenosis or tumor recurrence was observed in any of the four patients after a follow-up period of more than 24 months. Conclusion: The combination of the muscle-pedicle hyoid bone and the thyrohyoid flap is a reliable procedure for laryngeal reconstruction after extensive vertical partial or frontal partial laryngectomy. | Dian Ouyang Tian-Run Liu Yan-Feng Chen Jian Wang | 2013 | Cancer Biology & Medicine2013，10，2： | 3 |
| 19 | High electrocatalytic hydrogen evolution activity on a coupled Ru and CoO hybrid electrocatalyst显示文摘Hydrogen evolution reaction (HER) is an essential step in converting renewable energy to clean hydrogen fuel. Exploring highly efficient, stable and cost-effective electrocatalysts is of crucial significance for sustainable HER. Here, we report the design of a coupled ruthenium/cobalt oxide (Ru/CoO) hybrid electrocatalyst for alkaline HER. In this hybrid metal/oxide system, the complicated alkaline HER pathways are overall facilitated;oxygen (O)-vacancy-abundant oxide enhances water splitting and Ru promotes successive hydrogen intermediates to generate hydrogen. The resulting Ru/CoO hybrid electrocatalyst exhibits significantly promoted catalytic activity compared with benchmark Ru catalyst, displaying an overpotential of 55 mV to generate a HER current density of 10 mA cm^-2, comparable with the state-of-the-art Pt/C catalyst and the most efficient alkaline HER electrocatalysts. Furthermore, the strong interaction of Ru nanoparticles with oxide support and the in-situ growth of oxide support on conductive substrate guarantee the long-term stability of as-fabricated Ru/CoO hybrid electrocatalyst. This newly designed hybrid catalyst with abundant metal/oxide interfaces may pave a new pathway for exploring efficient and stable HER electrocatalysts. | Jia-Xin Guo Dong-Yang Yan Kang-Wen Qiu Chuan Mu Dian Jiao Jing Mao Hui Wang Tao Ling | 2019 | Journal of Energy Chemistry2019，28，10： | 3 |
| 20 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts显示文摘The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch.Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis. | Ling Ye Feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen Bo Gao Dingming Huang Peng Liu | 2018 | Bone Research2018，6，4： | 3 |
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