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| 1 | Vortex genesis over the Bay of Bengal in spring and its role in the onset of the Asian Summer Monsoon显示文摘Physical processes associated with onset of the 1998 Asian summer monsoon were examined in detail using multi-source datasets. We demonstrated that strong ocean-atmosphere-land interaction in the northern Indian Ocean and tropical Asian area during spring is a fundamental factor that induces the genesis and development of a monsoon onset vortex over the Bay of Bengal (BOB), with the vortex in turn triggering onset of the Asian summer monsoon. In spring, strong surface sensible heating over India and the Indochina Peninsula is transferred to the atmosphere, forming prominent in situ cyclonic circulation, with anticyclonic circulations over the Arabian Sea and northern BOB where the ocean receives abundant solar radiation. The corresponding surface winds along the North Indian Ocean coastal areas cause the ocean to produce the in situ offshore currents and upwelling, resulting in sea surface temperature (SST) cooling. With precipitation on the Indochina Peninsula increasing from late April to early May, the offshore current disappears in the eastern BOB or develops into an onshore current, leading to SST increasing. A southwest-northeast oriented spring BOB warm pool with SST >31°C forms in a band from the southeastern Arabian Sea to the eastern BOB. In early May, the Somali cross-equatorial flow forms due to the meridional SST gradient between the two hemispheres, and surface sensible heat over the African land surface. The Somali flow overlaps in phase with the anticyclone over the northern Arabian Sea in the course of its inertial fluctuation along the equator. The convergent cold northerlies on the eastern side of the anticyclone cause the westerly in the inertial trough to increase rapidly, so that enhanced sensible heat is released from the sea surface into the atmosphere. The cyclonic vorticity forced by such sensible heating is superimposed on the inertial trough, leading to its further increase in vorticity strength. Since atmospheric inertial motion is destroyed, the flow deviates from the inertial track in an intensified cyclonic curvature, and then turns northward toward the warm pool in the northern BOB. It therefore converges with the easterly flow on the south side of the anticyclone over the northern BOB, forming a cyclonic circulation center east of Sri Lanka. Co-located with the cyclonic circulation is a generation of atmospheric potential energy, due to lower tropospheric heating by the warm ocean. Eventually the BOB monsoon onset vortex (MOV) is generated east of Sri Lanka. As the MOV migrates northward to the warm pool it develops quickly such that the zonal oriented subtropical high is split over the eastern BOB. Thus, the tropical southwesterly on the southern and eastern sides of the MOV merges into the subtropical westerly in the north, leading to active convection over the eastern BOB and western Indochina Peninsula and onset of the Asian summer monsoon. | WU GuoXiong GUAN Yue WANG TongMei LIU YiMin YAN JingHui MAO JiangYu | 2011 | Science China Earth Sciences2011，54，1： | 16 |
| 2 | Prediction of H7N9 epidemic in China显示文摘 | Zhang Zhaojie Xia Yao Lu Yi Yang Jingchao Zhang Luwen Su Hui Lin Lili Wang Guoling Wang Tongmei Lin Shao Guo Zhongmin Lu Jiahai | 2014 | Chinese Medical Journal2014，，2： | 8 |
| 3 | Investigation of therapeutic modalities of G719X, an uncommon mutation in the EGFR gene in non-small cell lung cancer显示文摘Objective G719 X is the most frequently seen uncommon mutation of the epidermal growth factor receptor(EGFR) gene, which is a point mutation at exon 18 with three common subtypes, G719 A/G719 C/G719 S. This study explored the clinicopathological characteristics of the G719 X mutation and investigated the efficacy of EGFR-tyrosine kinase inhibitor(TKI) treatment and chemotherapy in patients with the G719 X mutation; the survival rate after these different treatment modalities were then analyzed in order to provide evidence for clinical treatment.Methods Clinical data of 41 patients with the G719 X mutation admitted in the Beijing Chest Hospital, Capital Medical University from September 2014 to July 2018, were collected and the EGFR mutations were detected by amplification refractory mutation system-polymerase chain reaction(ARMS-PCR). The clinicopathological characteristics of the G719 X mutation were analyzed, and the relationship among the G719 X mutation, the efficacy of different treatment modalities, and the progression-free survival(PFS) was analyzed. Results Of the 41 cases, 24(58.5%) were G719 X single mutations and 17(41.5%) were compound mutations, including G719 X/S768 I, G719 X/L861 Q, G719 X/19 del, and G719 X/c-Met compound mutation. The objective response rate(ORR) of first-line EGFR-TKI therapy was 50%(6/12), the disease control rate(DCR) was 83.3%(10/12), and the median PFS(mPFS) was 9 months. After resistance to EGFR-TKI in the previous treatment, the ORR(71.4%, 5/7) and DCR(100%, 7/7) were still high following EGFR-TKIs, by an mPFS of 8 months. The ORR of chemotherapy was 33.3%(2/6), the DCR was 100%(6/6), and the mPFS was 6 months. Conclusion G719 X is an uncommon mutation of the EGFR gene and is sensitive to many EGFR-TKIs. It can be treated with the second-or third-generation EGFR-TKIs after resistance to the first-generation EGFR-TKIs. G719 X mutation also showed favorable effect to chemotherapy. | Hua Zheng Yuan Gao Zan Liu Zhe Qian Tongmei Zhang Jie Li Hongmei Zhang Qunhui Wang Fanbin Hu Baolan Li | 2019 | Oncology and Translational Medicine2019，5，2： | 1 |
| 4 | A comparison between numerical simulation of forced local Hadley (Anti -Hadley) circulation in East Asin and Indian monsoon regions显示文摘 | YUAN Zhuo -jian WANG Tongmei HE Haiyan | 2000 | Advances in Atmospheric Sciences2000，17，5： | 1 |
| 5 | , The Influente of Mechanical and Thermal Forcing by the Tibetan Plateau on Asian climate显示文摘 | Guoxiong Wu Yimin Liu Tongmei Wang | 2007 | Journal of Hydrometeorology ( Special Section )2007，8，： | 1 |
| 6 | The expression of vascular endothelial growth factor(VEGF)/endostatin(ES)and VEGF receptor 2(VEGFR2)/ES is associated with NSCLC prognosis显示文摘Objective The aim of our study was to detect the expression of angiogenesis inhibitory proteins and angiogenesis promotive proteins in the postoperative tumor tissue of non-small cell lung cancer(NSCLC)patients.We also investigated the relationship of protein expression with clinical characteristics and prognosis.Methods We examined the expression of vascular endothelial growth factor(VEGF),VEGF receptor 2(VEGFR2),and endostatin(ES)proteins in 255 specimens resected from NSCLC patients,using immune histochemistry(IHC).We then evaluated the relationships between the expression of the three proteins and clinical characteristics such as stage,histological type,differentiation,gender,tobacco use,and age.According to the value of VEGF/ES,we divided the cohort into angiogenesis-promoting group A,angiogenesis-inhibiting group A,and balance group A.The survival differences in the three groups were evaluated to determine the prognostic value of VEGF/ES.Similarly,we tested the prognostic value of VEGFR2/ES.Results VEGF-positive expression was observed in 93 patients(36.4%).VEGF expression was not correlated with the clinical characteristics.VEGFR2-positive expression was observed in 103 patients(40.4%).The expression of VEGFR2 was correlated with the clinical stage(χ^(2)=21.414,P=0.045)and histological type(χ^(2)=26.911,P=0.008).ES-positive expression was observed in 140 patients(54.9%).The expression of ES was correlated with the clinical stage(χ^(2)=26.504,P=0.009).When evaluating the prognostic values of VEGF/ES and VEGFR2/ES,the prognosis of the angiogenesis balance group was similar to that of the angiogenesis-inhibiting group.The minimum survival time was observed in the angiogenesis-promoting group.Conclusion VEGF/ES and VEGFR2/ES in resected tumors have prognostic value in postoperative NSCLC patients.The survival time of the population with predominant angiogenic factors was short. | Yuan Yang Baohua Lu Baolan Li Weiying Li Mei Jiang Wentao Yue Qunhui Wang Tongmei Zhang | 2021 | Oncology and Translational Medicine2021，7，4： | 1 |
| 7 | (Tn5-)FISH-based imaging in the era of 3D/spatial genomics显示文摘3D genomics mainly focuses on the 3D position of single genes at the cell level,while spatial genomics focuses more on the tissue level.In this exciting new era of 3D/spatial genomics,half-century old FISH and its derivative methods,including Tn5-FISH,play important roles.In this review,we introduce the Tn5-FISH we developed recently,and present six different applications published by our collaborators and us,based on(Tn5-)FISH,which can be either general BAC clone-based FISH or Tn5-FISH.In these interesting cases,(Tn5-)FISH demonstrated its vigorous ability of targeting sub-chromosomal struc-tures across different diseases and cell lines(leukemia,mEsCs(mouse embryonic stem cells),and differentiation cell lines).Serving as an effective tool to image genomic structures at the kilobase level,Tn5-FISH holds great potential to detect chromosomal structures in a high-throughput manner,thus bringing the dawn for new discoveries in the great era of 3D/spatial genomics. | Liheng Yang Yan Yan JunLin Li Cheng Zhou Jinlan jin Tongmei Zhang Haokaifeng Wu Xingang Li Wei Wang Li Yuan Xu Zhang Juntao Gao | 2023 | Biophysics Reports2023，9，1： | 0 |
| 8 | PINK1-mediated Drp1^(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission显示文摘Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic efficacy.However,the underlying mechanism remains elusive.We show here that Pink1 knockout(KO)mice display defective dendritic spine maturation,reduced axonal synaptic vesicles,abnormal synaptic connection,and attenuated long-term synaptic potentiation(LTP).Drp1 activation via ^(S616) phosphorylation rescues deficits of spine maturation in Pink1 KO neurons. | Qingtao Gao Runyi Tian Hailong Han Jesse Slone Caifang Wang Xiao Ke Tongmei Zhang Xiangyu Li Yuhong He Panlin Liao Fang Wang Ye Chen Shiqing Fu Kexuan Zhang Fangfang Zeng Yingxuan Yang Zhuo Li Jieqiong Tan Jiada Li Youming Lu Taosheng Huang Zhonghua Hu Zhuohua Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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