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| 1 | Pyogenic liver abscess: Changing patterns in approach显示文摘AIM: To define optimum management of the pyogenic liver abscess and assess new trends in treatment. METHODS: One hundred and sixty nine patients with pyogenic liver abscess managed at Sher-i-Kashmir In- stitute of Medical Sciences, Srinagar, Kashmir (India) from July 2001 to August 2006 were studied to evaluate and define the optimum treatment. RESULTS: Mortality in the surgically treated group of patients was 9.4% (12/119), while those treated non-surgically had a fatality rate of 16.66% (7/42). Multiple liver abscesses treated surgically had a surprisingly low mortality of 30%. The biliary tract (64.97%) was the most common cause of liver abscess. Multiple abscesses, mixed organisms and abscess complications are all associated with a significantly increased mortality. However, the lethality of the primary disease process was the most important factor in determining survival.CONCLUSION: Transperitoneal surgical drainage and antibiotics are the mainstay of treatment. Percutaneous drainage is recommended for high risk patients only. | Ajaz A Malik Shams UL Bari Khawaja Abdul Rouf Khurshid Alam Wani | 2010 | World Journal of Gastrointestinal Surgery2010，2，12： | 15 |
| 2 | A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley显示文摘瞄准:为了系统地检验风险因素的关联的程度,例如年龄,与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法:所有情况(n = 51 ) 并且控制(n = 150 ) 是克什米尔山谷的永久居民。基因改变在 Tp53 肿瘤的前 ons 5-8 被决定压制或在 45 个 ESCC 盒子之中的基因组织学地由 PCR-SSCP 分析证实了。为单个癌症盒子的数据(n = 45 ) 并且住院病人控制(n = 150 ) 与非癌症,疾病在癌症的家庭历史上包括了信息,与病人的年龄组一起的三十个占优势的普通饮食的风险因素。在到从这些参数的万物有灵论的数据的 p53 前 ons 的基因损害的关联被 Chi 平方测试与健康控制一起产生到所有 45 个组织学地证实的 ESCC 盒子。结果:(77.8%) 45 中的 35 个组织学地描绘了与 45 正常样品中的 1 个对比的有的类似的体细胞突变从一样的耐心的显示出的细菌线变化从邻近的区域获得了的肿瘤样品。 SSCP 分析表明了改变在 6 上在前被发现的那很普通的 p53 基因(77.7%),那没与个人和 clinicopathological 参数的年龄相关,但是与癌症的家庭历史显示出重要词语索引( P<0.05 )( CD = 58 ),在消费的一个未知地点,和饮食的习惯建议细菌线倾向局部地种芥属蔬菜“ Hakh ”( CD = 19.5 ),红 chillies ( CD = 20.2 ),热咸苏打茶( CD = 2.37 )并且本地烤的面包( CD = 1.1 )。结论:我们的学习建议那体的染色体变化特别在 6 Tp53 基因上的前,在人种上的食道的癌症病人之中,克什米尔山谷的同质的人口是仔细与到各种各样的普通饮食的风险因素,特别热的咸茶,肉,烤的面包和“ Hakh ”的继续的暴露有关,那富于 nitrosoamines 和家庭癌症历史。 | Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar Ahmad Wani Ishfaq Ahmad Mohan Lal Bhat | 2006 | World Journal of Gastroenterology2006，12，25： | 8 |
| 3 | 在良性的胆汁的阻塞的 choledochoduodenostomy 的长期的结果显示文摘 AIM:To determine the long-term results of choledochodudenostomy in patients with benign billiary obstruction.METHODS:This prospective study was conducted at Sheri Kashmir Institute of Medical Sciences Srinagar Kashmir,India over a period of 10 years from January 1997 to December 2007.The total number of patients who underwent choledochoduodenostomy during this period was 270.On the basis of etiology of biliary tract obstruction,patients were divided into a calculus group,an oriental cholangiohepatitis group,a benign biliary stricture group and others.Patients were followed for a variable period of 13 mo to 15 years.RESULTS:Choledochoduodenostomy(CDD) with duodenotomy was performend in four patients.CDD with removal of T-tube,CDD with left hepatic lobectomy and CDD with removal of intra biliary ruptured hydatid was performed in three patients each.In the remaining patients only CDD was performed.Immediate post operative complications were seen in 63(23%) patients,while long-term complications were seen in 28(11%) patients,which were statistically significant.Three patients died during hospitalization while four patients died in the late post-operative period.CONCLUSION:Our conclusion is that CDD is safe and produces good long term results when a permanent biliary drainage procedure is required. | Ajaz A Malik Shiraz A Rather Shams UL Bari Khursheed Alam Wani | 2012 | World Journal of Gastrointestinal Surgery2012，4，2： | 7 |
| 4 | Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome[dagger]显示文摘 | El-Mahdy Mohamed A Zhu Qianzheng Wang Qi-En Wani Gulzar Patnaik Srinivas Zhao Qun Arafa El-Shaimaa Barakat Bassant Mir Safita N Wani Altaf A | 2008 | Photochemistry and Photobiology2008，，2： | 2 |
| 5 | Querce- tin protects against chronic aluminum- induced oxi- dative stress and ensuing biochemical, cholinergic, and neurobehavioral impairments in rats显示文摘 | Sharma DR Wani WY Sunkaria A | 2013 | Neurotox Res2013，23，4： | 1 |
| 6 | Protective efficacy ofmitochondrial targeted antioxidant MitoQ against dichlorvosinduced oxidative stress and cell death in rat brain显示文摘 | Wani W Y Gudup S Sunkaria A | 2011 | Neuropharmacology2011，61，8： | 1 |
| 7 | Plant antitumor agents(29): Synthesis and biological activity of ring D and ring E modified analogues of camptothecin显示文摘 | Nicholas A W Wani M C Manikumar G | 1990 | J Med Chem1990，33，3： | 1 |
| 8 | Enhanced gene andsiRNA delivery by polycation-modified mesoporous silica nanop-articles loaded with chloroquine显示文摘 | Bhattarai SR Muthuswamy E Wani A | 2010 | Pharrn Res2010，27，12： | 1 |
| 9 | Role of plant growth promotingrhizobacteria in the remediation of metal contaminated soils 显示文摘 | Khan MS Zaidi A Wani PA Oves M | 2009 | EnvironChem Lett2009，7，1： | 1 |
| 10 | 泛素依赖的蛋白酶体水解通路对p53转录活性的作用显示文摘目的 探讨 p5 3的转录过程与其泛素调节的蛋白降解途径的相互关系。方法 采用瞬时转染报告基因测定法 ,测定细胞裂解液荧光素酶活性 (p5 3的转录活性 )或Western -blot、免疫共沉淀测定细胞内 p5 3蛋白水平。结果 删除 p5 3N末端 1- 19个氨基酸 (mdm2结合位点 ) ,可显著减少 p5 3的转录活性 ,提示p5 3的降解片段不能与其转录活性片段相分离。特异性蛋白酶体抑制剂存在时 ,细胞内 p5 3稳态蛋白水平升高 ,而 p5 3的转录活性受到显著的抑制。UBA酶 (ubiquitin -activatingenzyme)失活 ,导致p5 3转录功能降低。结论 p5 | 姚继红 Qianzheng Zhu A A Wani 杨佩满 崔秀云 | 2002 | 解剖科学进展2002，8，4： | 1 |
| 11 | Narrow-band imaging colonoscopyda pilot feasibility study for the detection of polyps and correlation of surface patterns with polyp histologic diagnosis显示文摘 | RASTOGI A BANSAL A WANI S | 2008 | Gastrointest Endosc2008，67，2： | 1 |
| 12 | Effect of mulch on soil temperature, moisture, weed infestation and yield of groundnut in northern Vietnam 显示文摘 | Ramakrishna A Tamb H M Wani S P | 2006 | Field Crops Research2006，，95： | 1 |
| 13 | Effect of temperature, alkali concentration, mixing time and meal/solvent ratio on the extraction of watermelon seed proteins-a response surface approach显示文摘 | Wani A A Sogi D S Grover L | 2006 | Biosystems Engineering2006，94，1： | 1 |
| 14 | Production of the first cloned camel by somatic cell nuclear transfer显示文摘 | Wani N A Wernery U Hassan F A | | 0，，02： | 1 |
| 15 | Chromium-reducing and plant growthpromotingMesorhizobium improves chickpea growth in chromiumamendedsoil 显示文摘 | Wani PA Khan MS Zaidi A | 2008 | Biotechnol Lett2008，30，1： | 1 |
| 16 | Effect of mulch on temperature, moisture, weed infestation and yield of ground nut in northern Vietnam显示文摘 | Ramakrishna A Ham M M Wani S P | 2006 | Field Crops Researeh2006，95，： | 1 |
| 17 | Functions and stability of lycopene: a review显示文摘 | JABEEN R BHAT S V WANI A A | 2013 | Indian I-Iortic I2013，3，34： | 1 |
| 18 | Sweet cherry (Prunus avium): Critical factors affecting the composition and shelf life显示文摘 | Wani A A Singh P Gul K | 2014 | Food Packaging & Shelf Life2014，1，1： | 1 |
| 19 | Effect of harvesting technique on in vitro maturation and in vitro fertilization in sheep显示文摘 | Wani N A Wani G M Zkhan M | 2000 | Small Rumin Res2000，，36： | 1 |
| 20 | Role of plant growth promoting rhizobaeteria in the remediation of metal contaminated soils 显示文摘 | Khan M S Zaidi A Wani P A | 2009 | Environ Chem Lett2009，7，1： | 1 |
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