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| 1 | Mesenchymal stem cell-mediated cancer therapy: A dualtargeted strategy of personalized medicine显示文摘Cancer remains one of the leading causes of mortal-ity and morbidity throughout the world. To a signifi-cant extent, current conventional cancer therapies are symptomatic and passive in nature. The major obstacle to the development of effective cancer therapy is be-lieved to be the absence of suffi cient specifi city. Since the discovery of the tumor-oriented homing capacity of mesenchymal stem cells (MSCs), the application of specific anticancer gene-engineered MSCs has held great potential for cancer therapies. The dual-targeted strategy is based on MSCs’ capacity of tumor-directed migration and incorporation and in situ expression of tumor-specifi c anticancer genes. With the aim of trans-lating bench work into meaningful clinical applications, we describe the tumor tropism of MSCs and their use as therapeutic vehicles, the dual-targeted anticancer potential of engineered MSCs and a putative personal-ized strategy with anticancer gene-engineered MSCs. | Garth L Warnock | 2011 | World Journal of Stem Cells2011，3，11： | 7 |
| 2 | Improving outcomes from acute kidney injury: report of an initiative显示文摘 | Levin A Warnock D G Mehta R L | 2007 | Am J Kidney Dis2007，50，1： | 1 |
| 3 | Influences of non-herbaceous biochar on mbuscular mycorrhizal fungal abundances in mots and soils:results from growth-chamber and fded experiments显示文摘 | WARNOCK D D MUMMEY D L MCBRIDE B a al | | 0，，03： | 1 |
| 4 | Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection显示文摘 | Denning D W Radford S A Oakley K L Hall L Johnson E M Warnock D W | 1997 | J Antimicrob Chemother1997，40，： | 1 |
| 5 | A new approach to erythrocyte transketolase measurement显示文摘 | Warnock L G | 1970 | Journal of Nutrition1970，100，： | 1 |
| 6 | Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation 显示文摘 | Okorokov AL Warnock L Milner J | 2002 | Carcinogenesis2002，23，4： | 1 |
| 7 | Long-term graft function after allogeneic islet transplantation 显示文摘 | Lakey J R Kin T Warnock G L | 2007 | Cell Transplant2007，16，4： | 1 |
| 8 | Improved human pancreatic islet isolation for a prospective cohos study of islet transplantation vs best medical therapy in type 1 diabetes mellitus 显示文摘 | WARNOCK G L MELOCHE R M THOMPSON D | 2005 | Arch Surg2005，140，： | 1 |
| 9 | B7-H4 as a protective shield for pancreatic islet beta cells显示文摘Auto- and alloreactive T cells are major culprits that damage β-cells in type 1 diabetes(T1D) and islet transplantation. Current immunosuppressive drugs can alleviate immune-mediated attacks on islets. T cell co-stimulation blockade has shown great promise in autoimmunity and transplantation as it solely targets activated T cells, and therefore avoids toxicity of current immunosuppressive drugs. An attractive approach is offered by the newly-identified negative T cell cosignaling molecule B7-H4 which is expressed in normal human islets, and its expression co-localizes with insulin. A concomitant decrease in B7-H4/insulin colocalization is observed in human type 1 diabetic islets. B7-H4 may play protective roles in the pancreatic islets, preserving their function and survival. In this review we outline the protective effect of B7-H4 in the contexts of T1 D, islet cell transplantation, and potentially type 2 diabetes. Current evidence offers encouraging data regarding the role of B7-H4 in reversal of autoimmune diabetes and donor-specific islet allograft tolerance. Additionally, unique expression of B7-H4 may serve as a potential biomarker for the development of T1 D. Futurestudies should continue to focus on the islet-specific effects of B7-H4 with emphasis on mechanistic pathways in order to promote B7-H4 as a potential therapy and cure for T1 D. | Annika C Sun Dawei Ou Dan S Luciani Garth L Warnock | 2014 | World Journal of Diabetes2014，5，6： | 1 |
| 10 | Functional assessment of microencapsulated porcine islets with agarose polystyrene sulfonic acid in vitro and in xenotransplantation显示文摘 | Tashiro H Iwata H Warnock G L | 2005 | Transplant Proc2005，37，8： | 1 |
| 11 | Improving outcomes from acute kindey injury显示文摘 | Molitoris B A l evin A Warnock DG | 2007 | J Am Soc Nephrol2007，18，7： | 1 |
| 12 | The early management of severe tibial Pilon fractures using a temporary ring fixator显示文摘 | Mockford BJ Ogonda L Warnock D | 2003 | Surgeon2003，1，2： | 1 |
| 13 | Localization of ocular P2Y2 receptor gene expression by in situ hybridization显示文摘 | COWLEN MS ZHANG VZ WARNOCK L MOYER CF PETER- SON WM YERXA BR | 2003 | Exp Eye Res2003，77，1： | 1 |
| 14 | In- terleukin 4, but not interleukin 5 or eosinophils, is required ina murine model of acute airway hyperreactivity 显示文摘 | CORRY D B FOLKESSON H G WARNOCK M L | 1996 | J Exp Med1996，183，1： | 1 |
| 15 | The effect of cryopreservation on the survivaland MHC antigen expression murineislet allograft显示文摘 | Cattral M S Warnock G L | 1993 | Transplantation1993，55，： | 1 |
| 16 | Localization of ocular P2Y2 receptor gene expression by in situ hybridization显示文摘 | Cowlen MS Zhang VZ Warnock L Moyer CF Peterson WM Yerxa BR | 2003 | Exp Eye Res2003，77，： | 1 |
| 17 | Resistance of Greenhouse, Laboratory, and Native Populations of Western Flower Thrips to Spinosad显示文摘 | LOUGHNER R L WARNOCK D F CLOYD R A | 2005 | Hortscience2005，40，： | 1 |
| 18 | Acute bipolar mania: a systematic review and meta-analysis of co-therapy vs monotherapy 显示文摘 | Smith L A Cornelius V Warnock A | 2007 | Acta Psychiatr Scand2007，115，1： | 1 |
| 19 | 2010, Influences of non-herbaceous biochar on arbuscular mycorrhizal fungal abundances in roots and soils: Results from growth-chamber and field experiments显示文摘 | WARNOCK D D Mummey D L MCBRIDE B | 2010 | Applied Soil Ecology2010，46，： | 1 |
| 20 | Pulmonary asapergilosis inmaging finding with pathologic correlation显示文摘 | AQUINO S L KEE S T WARNOCK I L | 1994 | AJR1994，163，4： | 1 |
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