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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Improved Technique for the Routine Determination of Tritiated Water in Aqueous Samples显示文摘 | Warwick P E Croudace I W Howard A G | 1999 | Anal Chim Acta1999，382，： | 2 |
| 3 | Penetritration of tritium ( as tritiated water- vapour) into low carbon steel and remediated using abrasive cleaning显示文摘 | LEWIS A WARWICK P E CROUDACE I W | 2005 | J Radio Prot2005，25，： | 1 |
| 4 | The effect of increasing salinity on the growth and ion content of three non-halophytic wetland macrophytes显示文摘 | Warwick N W M Bailey P C E | 1997 | Aquatic Botany1997，58，： | 1 |
| 5 | A comparison of the effects of eitalopram and moclobemide on resting brain perfu- sion in social anxiety disorder显示文摘 | Warwick JM Carey P Van der linden G | 2006 | Metab Brain Dis2006，21，23： | 1 |
| 6 | The advanced light source U8 beam line, 20-300 eV显示文摘 | Heimann P A Warwick T Howells M R | 1992 | Nucl Instr Meth1992，319，： | 1 |
| 7 | Spectrophoto-metric Determination of Uranium With Arsenazo-Ⅲin Perchloric Acid显示文摘 | Khan M H Warwick P Evans N | 2006 | Chemosphere2006，63，： | 1 |
| 8 | Sampling and analyses of colloids at the Drigg low level radioactive waste disposal site 显示文摘 | Warwick P Allinson S Beckett K Eilbeck A Fairhurst A Russe-Flint K Verra11 K | 2002 | Journal of Environmental Monitoring2002，4，2： | 1 |
| 9 | Iron-magnesium hydroxycarbonate (fermegate) : a novel non-calcium-containing phosphate binder for the treatment of hyper-phosphatemia in chronic hemodialysis patients 显示文摘 | Mclntyre C W Pai P Warwick G | 2009 | Clin J Am Soc Nephrol2009，4，2： | 1 |
| 10 | A robust nonlinear identification algorithm using PRESS statistic and forward regression显示文摘 | HONG X SHARKEY P M WARWICK K | 2003 | IEEE Transactions on Neural Networks2003，14，2： | 1 |
| 11 | The advanced light source U8 beam line, 20-300 eV 显示文摘 | Heimann P A Warwick T Howells M R | 1992 | Nucl Instr Meth1992，319，： | 1 |
| 12 | Magnesium-lithium alloys in metal matrix composites 显示文摘 | Mason J F Warwick C M Smith P J | 1989 | A Preliminary Report Joumal of Materials Science1989，24，： | 1 |
| 13 | Three new polymorphisms in the human complement factor H gene and promoter region显示文摘 | Warwicker P Goodship TH Goodship JA | 1997 | Immunogenetics1997，46，5： | 1 |
| 14 | Familial relapsing haemolytic uraemic syndrome and complement factor H deficiency 显示文摘 | Warwicker P Donne RL Goodship JA | 1999 | Nephrol Dial Transplant1999，，5： | 1 |
| 15 | Bioassay for estimating the biogenic methane-generating potential of coal samples显示文摘 | Jones EJ Voytek MA Warwick P | 2008 | International Journal of Coal Geology2008，76，12： | 1 |
| 16 | The Influence of Humic Acid on the Adsorption of Europium Onto Inorganic Colloids as a Function of pH显示文摘 | Fairhurst A J Warwick P Richardson S | 1995 | Radiochim Acta1995，69，： | 1 |
| 17 | A cellular hypothesis for the induction of blossom-end rot in tomato fruit 显示文摘 | LIMC H O WHITE P J WARWICK H R I | 2005 | Annals of Botany2005，95，： | 1 |
| 18 | Successful treatment of factor H-related haemolytic uraemic syndrome显示文摘 | Stratton JD Warwicker P | 2002 | Nephrol Dial Transplant2002，17，4： | 1 |
| 19 | Zinc and cadmium mobility in sand:effects of pH,speciation,cation exchange capacity (CEC),humic acid and metal ions显示文摘 | WARWICK P HALL A PASHLEY V | 1998 | Chemosphere1998，36，10： | 1 |
| 20 | The health anxie-ty inventory development and validation of scales for the measure-ment of health anxiety and hypochondriasis显示文摘 | Salkovskis P M Rimes K A Warwick H M | 2002 | Psycho Med2002，32，5： | 1 |
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