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| 1 | The gravity field and crustal thickness of Venus显示文摘The gravity and topography of Venus obtained from observations of the Magellan mission, as well as the gravity and topography from our numerical mantle convection model, are discussed in this paper. We used the hypothesis that the geoid of degrees 2–40 is produced by sublithospheric mantle density anomalies that are associated with dynamical process within the mantle. We obtained the model dynamical admittance(the geoid topography ratio based on a convection model) by a numerical simulation of the Venusian mantle convection, and used it to correct the dynamical effect in the calculation of crustal thickness. After deducting the dynamical effect, the thickness of the Venusian crust is presented. The results show that the gravity and topography are strongly correlated with the Venusian mantle convection and the Venusian crust has a significant influence on the topography. The Venusian crustal thickness varies from 28 to 70 km. Ishtar Terra, and Ovda Regio and Thetis Regio in western Aphrodite Terra have the highest crustal thickness(larger than 50 km). The high topography of these areas is thought to be supported by crustal compensation and our results are consistent with the hypothesis that these areas are remnants of ancient continents. The crustal thickness in the Beta, Themis, Dione, Eistla, Bell, and Lada regiones is thin and shows less correlation with the topography, especially in the Atla and Imdr regiones in the eastern part of Aphrodite Terra. This is consistent with the hypothesis that these highlands are mainly supported by mantle plumes. Compared with the crustal thickness calculated with the dynamical effect, our results are more consistent with the crust evolution and internal dynamical process of Venus. | WEI DaiYun YANG An HUANG JinShui | 2014 | Science China Earth Sciences2014，57，9： | 4 |
| 2 | m6A-TSHub:Unveiling the Context-specific m^(6)A Methylation and m^(6)A-affecting Mutations in 23 Human Tissues显示文摘As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs(lncRNAs),N6-methyladenosine(m^(6)A)RNA methylation has been shown to participate in essential biological processes.Recent studies have revealed the distinct patterns of m^(6)A methylome across human tissues,and a major challenge remains in elucidating the tissue-specific presence and circuitry of m^(6)A methylation.We present here a comprehensive online platform,m^(6)A-TSHub,for unveiling the context-specific m^(6)A methylation and genetic mutations that potentially regulate m^(6)A epigenetic mark.m^(6)A-TSHub consists of four core components,including(1)m^(6)A-TSDB,a comprehensive database of 184,554 functionally annotated m^(6)A sites derived from 23 human tissues and 499,369 m^(6)A sites from 25 tumor conditions,respectively;(2)m^(6)A-TSFinder,a web server for high-accuracy prediction of m^(6)A methylation sites within a specific tissue from RNA sequences,which was constructed using multi-instance deep neural networks with gated attention;(3)m^(6)ATSVar,a web server for assessing the impact of genetic variants on tissue-specific m^(6)A RNA modifications;and(4)m^(6)A-CAVar,a database of 587,983 The Cancer Genome Atlas(TCGA)cancer mutations(derived from 27 cancer types)that were predicted to affect m^(6)A modifications in the primary tissue of cancers.The database should make a useful resource for studying the m^(6)A methylome and the genetic factors of epitranscriptome disturbance in a specific tissue(or cancer type).m^(6)A-TSHub is accessible at www.xjtlu.edu.cn/biologicalsciences/m^(6)ats. | Bowen Song Daiyun Huang Yuxin Zhang Zhen Wei Jionglong Su João Pedro de Magalhães Daniel J.Rigden Jia Meng Kunqi Chen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 3 | Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy显示文摘The field of two-dimensional(2D)nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science,nano-chemistry,in particular nanobiological interactions,immunology,and medicinal chemistry.Most importantly,the'biological identity'of nanomaterials governed by bio-molecular corona in terms of bimolecular types,relative abundance,and conformation at the nanomaterial surface is now believed to influence blood circulation time,biodistribution,immune response,cellular uptake,and intracellular trafficking.A better understanding of nano-bio interactions can improve utilization of 2D nano-architectures for cancer immunotherapy and immunotheranostics,allowing them to be adapted or modified to treat other immune dysregulation syndromes including autoimmune diseases or inflammation,infection,tissue regeneration,and transplantation.The manuscript reviews the biological interactions and immunotherapeutic applications of 2D nanomaterials,including understanding their interactions with biological molecules of the immune system,summarizes and prospects the applications of 2D nanomaterials in cancer immunotherapy. | Zhongmin Tang Yufen Xiao Na Kong Chuang Liu Wei Chen Xiangang Huang Daiyun Xu Jiang Ouyang Chan Feng Cong Wang Junqing Wang Han Zhang Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 0 |
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