| 1 | Prediction of Drug-Drug Interactions Based on Multi-layer Feature Selection and Data Balance显示文摘Drug-drug interactions(DDIs)occur when two drugs react with each other,which may cause unexpected side effects and even death of the patient.Methods that use adverse event reports to predict unexpected DDIs are limited by two critical yet challenging issues.One is the difficulty of selecting discriminative features from numerous redundant and irrelevant adverse events for modeling.The other is the data imbalance,i.e.,the drug pairs causing adverse effects are far less than those not causing adverse effects,which leads to poor accuracy of DDIs detection.We propose a multi-layer feature selection method to select discriminative adverse events and apply an over-sampling technique to make the data balanced.The experimental results show that the validation accuracy of positive DDIs on the Canada Vigilance Adverse Reaction Online Database increases to two times,and 110 DDIs are identified on the drug interactions checker of Drugs.com in USA. | YUE Kejuan ZOU Beiji WANG Lei LI Xiao ZENG Min WEI Faran | 2017 | Chinese Journal of Electronics2017，26，3： | 1 |
| 2 | Tango Controls and data pipeline for petawatt laser experiments显示文摘The Centre for Advanced Laser Applications in Garching,Germany,is home to the ATLAS-3000 multi-petawatt laser,dedicated to research on laser particle acceleration and its applications.A control system based on Tango Controls is implemented for both the laser and four experimental areas.The device server approach features high modularity,which,in addition to the hardware control,enables a quick extension of the system and allows for automated data acquisition of the laser parameters and experimental data for each laser shot.In this paper we present an overview of our implementation of the control system,as well as our advances in terms of experimental operation,online supervision and data processing.We also give an outlook on advanced experimental supervision and online data evaluation–where the data can be processed in a pipeline–which is being developed on the basis of this infrastructure. | Nils Weiße Leonard Doyle Johannes Gebhard Felix Balling Florian Schweiger Florian Haberstroh Laura D.Geulig Jinpu Lin Faran Irshad Jannik Esslinger Sonja Gerlach Max Gilljohann Vignesh Vaidyanathan Dennis Siebert Andreas Münzer Gregor Schilling Jörg Schreiber Peter G.Thirolf Stefan Karsch Andreas Döpp | 2023 | High Power Laser Science and Engineering2023，11，4： | 0 |
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