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| 1 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 2 | The tissue renin-angiotensin-aldosterone system in diabetes mellitus显示文摘 | Hanes D S Nahar A Weir M R | 2004 | Cruu Hypertens Rep2004，6，2： | 1 |
| 3 | Chemical interconversion of T-2 and HT - 2 toxins and related compounds 显示文摘 | WEIR D STRONG F M SMALLEY E B | 1971 | Biochem BiophysRes Commun1971，45，： | 1 |
| 4 | Detecting marker-disease association by testing for hardy-weinberg disequilibrium at a marker locus显示文摘 | EHM M G WEIR B S | 1999 | Am J Hum Genet1999，63，： | 1 |
| 5 | The effect of tin of clot removal on chronic vasospasm in a primate model 显示文摘 | Yuji Handa Bryce K A Weir M D | 1987 | Neurosurg1987，67，： | 1 |
| 6 | An injectable calcium phosphate alginate hydrogel umbilical cord mesenchymal stem cell paste for bone tissue engineering显示文摘 | ZHAO L WEIR M D XU H H K | 2010 | Biomaterials2010，31，25： | 1 |
| 7 | Folic acid metabolism and mechanisms of neural tube defects显示文摘 | Scott J M Weir D G Molloy A | 1994 | Ciba Found Symp1994，181，： | 1 |
| 8 | Fast-Degradable mi- crobeads encapsulating human umbilical cord stein cells in alg- inate for muscle tissue engineering 显示文摘 | LIU J ZHOU H Z WEIR M D | 2012 | Tissue Eng Part A2012，18，2122： | 1 |
| 9 | Reverse engineering physical models employing wrap around B-spline surfaces and quadrics显示文摘 | Weir D J Milroy M Bradley C | 1996 | Journal of Engineering Manufacture-Part B1996，210，： | 1 |
| 10 | Reverse Engineering Physical Models Employing Wrap-around B-Spline Surfaces and Quadrics 显示文摘 | Weir D J Milroy M J Bradley C | 1996 | Proc Introduction Mesh Engineers: Part B1996，210，2： | 1 |
| 11 | Reverse Engineering Physical Models Employing Wrap-around B - spline Surfaces and Quadrics 显示文摘 | WEIR D J BENG MILROY M J BRADLEY C | 1996 | Proc Instn Mech Engrs1996，210，8： | 1 |
| 12 | A single monooxygensse, ese, is involved in the metabolism of the organochlorides endosulfan and endosulfate in and arthrobacter sp显示文摘 | Weir K M Sutherland T D Home I | 2006 | Appl Envinm Microbiol2006，72，： | 1 |
| 13 | Resources and equity owner- ship in UVs in Turkey显示文摘 | DEMIRBAG M WEIR D | 2006 | Thunderbird International Bus- iness Review2006，48，1： | 1 |
| 14 | Reverse engineering physical models employing wrap around B-Spline surfaces and quadrics 显示文摘 | Milroy M J Bradley C | 1996 | Journal of Engineering Manufacture1996，，： | 1 |
| 15 | Injectable and macroporous calcium phosphate cement scaffold显示文摘 | Xu H H K Weir M D Burguera E F | 2006 | Biomaterials2006，27，： | 1 |
| 16 | Thermodynamic effects on developed cavitation显示文摘 | Holl J W Billet M L Weir D S | 1975 | Journal of Fluids Engineering1975，97，4： | 1 |
| 17 | Injectable and maeroporous calcium phosphate cement scaffold 显示文摘 | Xu H H K Weir M D Burgueral E F | 2006 | Biomaterials2006，27，： | 1 |
| 18 | Reverse engineering physical model employing wrap-around B-spline surfaces显示文摘 | D J Weir M J Milroy C Bradley | 1996 | ImechE1996，210，： | 1 |
| 19 | Reverse engineering physical models employing wrap-aroud-spline surfaces and quadrics显示文摘 | Weir D J Milroy M Bradley C | 1996 | Proc Introduction Mech Engrs-Part BIC J1996，210，2： | 1 |
| 20 | Low Success Rate of Repeat Shock Wave Lithotripsy for Ureteral Stones after Failed Initial Treatment显示文摘 | Pace D T Weir M J Tariq N | 2000 | J Urol2000，164，： | 1 |
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