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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 3 | Transport of genistein-7-glucoside by human intestinal Caco-2 cells: poteintial role for MRP2 显示文摘 | Wells U K French K L Walgren R A | 1999 | Res Comm Mole Pathol Pharm1999，103，1： | 1 |
| 4 | Correlation of time temperature indicator response with microbial growth in pasteurized milk 显示文摘 | GRISIUS R WELLS J H BARRET E L | 1987 | Journal of Food Processing and Preservation1987，11，： | 1 |
| 5 | Preliminary results of a randomized study of aafety and tolerability of three oxaliplatinbased regimens as first-line treatment for advanced colorectal cancer显示文摘 | Welles L Hochster H Ramanathan R | 2004 | J Clin Oncol2004，2，： | 1 |
| 6 | Bottlenose dolphins as marine ecosystem sentinels:Developing a health monitoring system显示文摘 | WELLS R S RHINEHART H L HANSEN L J | 2004 | Eco Health2004，1，： | 1 |
| 7 | Genetic variability for seed size of two-and three parent soybean population显示文摘 | Johnson S L W R Fehr G A Wells | 2001 | Crop Science2001，41，： | 1 |
| 8 | Adaptive segmentation of MRI data显示文摘 | Wells III W M Grimson W E L Kikins R | | 0，，04： | 1 |
| 9 | Selective harmonic control:a general problem formulation and selected solutions显示文摘 | WELLS J R NEE B M CHAPMAN P L | 2005 | IEEE Transactions on Power Electronics2005，20，6： | 1 |
| 10 | Modulation-based harmonic elimination 显示文摘 | WELLS J R GENG X CHAPMAN P L | 2007 | IEEETransactions on Power Electroncis2007，22，1： | 1 |
| 11 | Circumventing multidrug resistance in cancer by beta-galactoside binding protein,an antiproliferative cytokine显示文摘 | Ravatn R Wells V Nelson L | 2005 | Cancer Res2005，65，5： | 1 |
| 12 | Adaptive segmentation of MRI data显示文摘 | Wells W M I Grimson W E L Kikinis R | 1996 | IEEE Transactions on Medical Imaging1996，15，4： | 1 |
| 13 | Sprouting of seeds and nutrient composition of seeds and sprouts显示文摘 | Fordham J R Wells G E Chan L H | 1975 | Food Sci1975，40，： | 1 |
| 14 | Sprouting uf seeds and nutrient eomposition of seeds and sprouts 显示文摘 | Fordham J R Wells C E Chen L H | 1975 | Journal of Food Science1975，40，3： | 1 |
| 15 | Hospitalized patients with2009H1N1influenza in the United States,April-June2009显示文摘 | Jain S Kamimoto L Bramley AM Schmitz AM Benoit SR Louie J Sugerman DE Druckenmiller JK Ritger KA Chugh R Jasuja S Deutscher M Chen S Walker JD Duchin JS Lett S Soliva S Wells EV Swerdlow D Uyeki TM Fiore AE Olsen SJ Fry AM Bridges CB Finelli L 2009Pandemic Influenza A(H1N1)Virus Hospitalizations Investigation Team | 2009 | N Engl J Med2009，361，20： | 1 |
| 16 | {Ga (NH) 3/2} n, a new polymeric precursor for gallium nitride powders显示文摘 | Janik J F Wells R L Gallium imide | 1996 | Chem Mater1996，8，： | 1 |
| 17 | Iron overload in myel- odysplastic syndromes 显示文摘 | CHODIRKER L WELLS R A | 2009 | Expert Rev Hematol2009，2，： | 1 |
| 18 | Simulating the propagation of displacement discontinuities in a regularized strain-softening medium显示文摘 | Wells G N Sluys L J Borst R | 2002 | International Journal for Numerical Methods in Engineering2002，53，： | 1 |
| 19 | Comparison of thebehaviour of three herbicides in a field experiment under baresoil conditions显示文摘 | Siimes K R?m? S Welling L | 2006 | Agri Water Manag2006，84，12： | 1 |
| 20 | Selective harmonic control:a general problem formulation and selected solutions显示文摘 | WELLS J R NEE B M CHAPMAN P L | 2005 | IEEE Trans On Power Electronics2005，20，60： | 1 |
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