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| 1 | Spatial Distribution of Seismic Landslides in the Areas of 1927 Gulang M8.0 Earthquake显示文摘The 1927 Gulang M8.0 earthquake has triggered a huge number of landslides,resulting in massive loss of people’s life and property.However,integrated investigations and results regarding the landslides triggered by this earthquake are rare;such situation hinders the deep understanding of these landslides such as scale,extent,and distribution.With the support of Google Earth software,this study intends to finish the seismic landslides interpretation work in the areas of Gulang earthquake(VIII-XI degree)using the artificial visual interpretation method,and further analyze the spatial distribution and impact factors of these landslides.The results show that the earthquake has triggered at least 936 landslides in the VIII-XI degree zone,with a total landslide area of 58.6 km^2.The dense area of seismic landslides is located in the middle and southern parts of the X intensity circle.Statistical analysis shows that seismic landslides is mainly controlled by factors such as elevation,slope gradient,slope direction,strata,seismic intensity,faults and rivers.The elevation of 2000-2800 m is the high-incidence interval of the landslide.The landslide density is larger with a higher slope gradient.East and west directions are the dominant sliding directions.The areas with Cretaceous and Quaternary strata are the main areas of the Gulang seismic landslides.The X intensity zone triggered the most landslides.In addition,landslides often occur in regions near rivers and faults.This paper provides a scientific reference for exploring the development regularities of landslides triggered by the 1927 Gulang earthquake and effectively mitigating the landslide disasters of the earthquake. | XU Jixiang XU Chong HE Xiangli WEN Boyu GE Keshui BAI Yuzhu | 2020 | Earthquake Research in China2020，34，1： | 4 |
| 2 | Hazard Assessment of Co-seismic Landslides Based on Information Value Method:A Case in 2018 MW6.6 Hokkaido Earthquake,Japan显示文摘An MW6.6 earthquake occurred in eastern Hokkaido,Japan on September 6th,2018.Based on the pre-earthquake image from Google Earth and the post-earthquake image from high resolution(3 m)planet satellite,we manually interpret 9293 coseismic landslides and select 7 influencing factors of seismic landslide,such as elevation,slope,slope direction,road distance,flow distance,peak ground acceleration(PGA)and lithology.Then,9293 landslide points are randomly divided into training samples and validation samples with a proportion of 7:3.In detail,the training sample has 6505 landslide points and the validation sample has 2788 landslide points.The hazard risk assessment of seismic landslide is conducted by using the information value method and the study area is further divided into five risk grades,including very low risk area,low risk area,moderate risk area high risk area and very high risk area.The results show that there are 7576 landslides in high risk area and very high risk area,accounting for81.52%of the total landslide number,and the landslide area is 22.93 km^2,accounting for 74.35%of the total area.The hazard zoning is in high accordance with the actual situation.The evaluation results are tested by using the curve of cumulative percentage of hazardous area and cumulative percentage of landslides number.The results show that the success rate of the information value method is 78.50%and the prediction rate is 78.43%.The evaluation results are satisfactory,indicating that the hazard risk assessment results based on information value method may provide scientific reference for landslide hazard risk assessment as well as the disaster prevention and mitigation in the study area. | WEN Boyu XU Chong HE Xiangli MA Siyuan SHAO Xiaoyi LI Kai ZHANG Zhongjian LI Zhengfang | 2020 | Earthquake Research in China2020，34，1： | 2 |
| 3 | FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth显示文摘Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FBXW7β,a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC,is an E3 ligase of fatty acid synthase(FASN).Cancer-specific FBXW7βmutations that could not degrade FASN can lead to sustained lipogenesis in CRC.COP9 signalosome subunit 6(CSN6),an oncogenic marker of CRC,increases lipogenesis via interacting with and stabilizing FASN.Mechanistic studies show that CSN6 associates with both FBXW7βand FASN,and antagonizes FBXW7β’s activity by enhancing FBXW7βautoubiquitination and degradation,which in turn prevents FBXW7β-mediated FASN ubiquitination and degradation,thereby regulating lipogenesis positively.Both CSN6 and FASN are positively correlated in CRC,and CSN6-FASN axis,regulated by EGF,is responsible for poor prognosis of CRC.The EGF-CSN6-FASN axis promotes tumor growth and implies a treatment strategy of combination of orlistat and cetuximab.Patient-derived xenograft experiments prove the effectiveness of employing orlistat and cetuximab combination in suppressing tumor growth for CSN6/FASN-high CRC.Thus,CSN6-FASN axis reprograms lipogenesis to promote tumor growth and is a target for cancer intervening strategy in CRC. | Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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